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However, the mutations reported in the published literature display wide variations across racial and geographical groups. Hence, natural history, long-term outcome, and genotype-phenotypic correlation studies in patients with various hepatic GSDs are needed for a deeper understanding. Considering the emerging evidence of genetic profiling of patients with hepatic GSDs, including the recent study by Vanduangden et al , this editorial aims to review the various clinical subtypes, the spectrum of genetic mutations, and genotype-phenotype correlations for various hepatic GSDs.<\/jats:p>","DOI":"10.5409\/wjcp.v14.i3.103415","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T03:33:36Z","timestamp":1750044816000},"source":"Crossref","is-referenced-by-count":1,"title":["Hepatic glycogen storage disease: Deciphering the genotype-phenotype conundrum"],"prefix":"10.5409","volume":"14","author":[{"given":"Arghya","family":"Samanta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000001158"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01573-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9744-1"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-002-1016-7"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)38504-1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(78)91371-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/s0046-8177(74)80024-9"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i25.3932"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.1.49"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-005-0184-9"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1023\/a:1016572706488"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-002-0999-4"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.105232"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-3-199402010-00008"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118799"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-015-9811-2"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-008-0919-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/BF01800225"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200632"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9426"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-016-9932-2"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-015-2546-0"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/BF00443106"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2018-0151"},{"key":"B25","unstructured":"ANDERSEN DH. 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