{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:01:10Z","timestamp":1791489670700,"version":"4.3.4"},"reference-count":34,"publisher":"Baishideng Publishing Group Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Pediatr"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Giant coronary artery aneurysms (CAA), entailing thrombosis, myocardial infarction, and sudden death, are the most severe and life-threatening complications of Kawasaki disease (KD). Giant aneurysms rarely regress and can later transform into stenoses. Data on dynamic follow-up are scarce in the literature.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To evaluate clinical features and long-term outcomes of giant CAA in children with KD.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>A single-center retrospective study included data from patients with KD and giant CAA in the Irkutsk region (2012-2023). CAA criteria according to the American Heart Association guidelines of 2017 were used: (1) Dilated coronary artery with diameter Z -score &gt; 2 standard deviations (SD) but &lt; 2.5 SD; (2) Small CAA with Z -score &gt; 2.5 SD but &lt; 5 SD; (3) Medium CAA with Z -score &gt; 5 SD but &lt; 10 SD; and (4) Giant CAA with Z -score &gt; 10 SD or \u2265 8 mm.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>The mean age of children with coronary dilatation\/aneurysms was 2.5 years, and the male-to-female ratio was 3:1. Patients with giant\/medium CAA had symptoms of cerebral dysfunction more often compared with children with moderate (Z -score &lt; 5 SD but &gt; 2.0 SD) coronary dilatation (62.0% vs  21.0%, P  = 0.019). Major cardiovascular events (myocardial infarction, coronary artery bypass grafting, acute coronary syndrome, ischemic cardiomyopathy, left ventricular aneurysm, and giant extracardiac aneurysm) occurred in 55.5% of patients who had giant CAA. At follow-up the complete regression of giant\/medium CAA was observed in 58.0% and partial regression in 42.0% after a mean of 2.3 and 5.5 years, respectively. All thrombi detected by echocardiography, CT, and angiography in giant\/medium CAA disappeared between 1 year and 5 years (mean: 15 months). All patients survived.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>Risk factors for giant CAA were male sex, early age, and cerebral dysfunction. Complete regression of giant coronary aneurysms occurred in 58.0% of patients after follow-up of 2.3 years.<\/jats:p>","DOI":"10.5409\/wjcp.v14.i4.108920","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T02:38:08Z","timestamp":1761878288000},"source":"Crossref","is-referenced-by-count":1,"title":["Giant coronary aneurysms in children with Kawasaki disease and major cardiac complications and dynamic follow-up"],"prefix":"10.5409","volume":"14","author":[{"given":"Liudmila V","family":"Bregel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olesya S","family":"Efremova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir A","family":"Podkamenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurii A","family":"Kozlov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail M","family":"Kostik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000484"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-0433"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.978213"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/bjrcr\/uaad008"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2016.07.004"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2069.41059"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2014.44.1.54"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951117001470"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02798-6"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.24110\/0031-403x-2023-102-5-246-251"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.24110\/0031-403x-2019-98-3-284-290"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.24110\/0031-403x-2021-100-1-271-276"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.112.965194"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(87)80246-9"},{"key":"B15","unstructured":"Yokoi H. 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