{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:37:33Z","timestamp":1791873453791,"version":"4.3.4"},"reference-count":27,"publisher":"Baishideng Publishing Group Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Clin Pediatr"],"abstract":"<jats:p>Vitamin D deficiency is disproportionately prevalent among overweight and obese children, with conventional explanations such as poor dietary intake or reduced sun exposure offering only partial insight. Emerging evidence reveals a multifactorial pathophysiology, including sequestration of vitamin D in adipose tissue, altered hepatic metabolism, diminished bioavailability, and inflammation-induced resistance at the tissue level. These mechanisms contribute to a functional deficiency, wherein serum 25-hydroxyvitamin D levels may remain suboptimal despite adequate intake or sun exposure. Obesity-related alterations in vitamin D-binding proteins, receptor expression, and pro-inflammatory signaling further compromise biological activity. Current diagnostic criteria and supplementation guidelines do not fully reflect these physiological complexities, leading to underdiagnosis and insufficient treatment. Personalized approaches-incorporating higher, body composition-adjusted dosing and consideration of inflammatory status-are emerging as promising strategies to restore sufficiency and improve metabolic outcomes. While preliminary evidence supports the safety and efficacy of high-dose supplementation in this population, pediatric-specific clinical trials are lacking. This review synthesizes current understanding of the pathophysiological mechanisms underlying vitamin D deficiency in pediatric obesity and emphasizes the need for individualized, evidence-based interventions to optimize vitamin D status and overall health.<\/jats:p>","DOI":"10.5409\/wjcp.v14.i4.110357","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T02:38:08Z","timestamp":1761878288000},"source":"Crossref","is-referenced-by-count":3,"title":["Uncovering hidden vitamin D deficiency in overweight children"],"prefix":"10.5409","volume":"14","author":[{"given":"Chandra Sekhar","family":"Devulapalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.690"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1711"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17078"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.1.150"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2024-0527"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1575"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2007.20.7.817"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.112"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0188"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3686"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306357"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515003372"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.915678"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S287205"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/diseases13070219"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1281112"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1061496"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1543925"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51377-5"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2147\/NDS.S52024"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1466270"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz340"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106793"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2013.06.006"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041093"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-023-03301-x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.050013"}],"container-title":["World Journal of Clinical Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2219-2808\/full\/v14\/i4\/110357.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2219-2808\/full\/v14\/i4\/110357.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T02:48:08Z","timestamp":1761878888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2219-2808\/full\/v14\/i4\/110357.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":27,"journal-issue":{"issue":"4"},"alternative-id":["110357"],"URL":"https:\/\/doi.org\/10.5409\/wjcp.v14.i4.110357","relation":{},"ISSN":["2219-2808"],"issn-type":[{"value":"2219-2808","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,9]]}}}