{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:30:47Z","timestamp":1787506247731,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions, most commonly triggered by medications, characterized by extensive necrosis and detachment of the epidermis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated the differences in clinical characteristics of drug-induced SJS\/TEN depending on the type of drug in a single center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The relevance of sex, age, culprit drugs, clinical features, courses, treatment options, and follow-up results were retrospectively evaluated in patients diagnosed with drug-induced SJS\/TEN at Pusan National University Hospital between 2008 and 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety-two patients with a mean age of 58.7 \u00b1 20.2 years (range, 10-93 years) were included in the study. Those aged 60-80 years accounted for the largest number of patients (42.4%). Patients with drug-induced SJS\/TEN comprised 40 women (43.5%) and 52 men (56.5%). We categorized drug-induced SJS\/TEN cases by culprit drugs into 6 groups: antibiotics, allopurinol, antiepileptic (AED), nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and other drugs. The rate of NSAID-induced disease significantly increased from SJS to TEN (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.016). Among the patients in the NSAID group, the proportion of TEN (40%) was higher than that in the other groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.021). The mean body surface area was significantly lower in the AED group than in the non-AED groups (7.1 \u00b1 9.8 vs. 23.1 \u00b1 27.3,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.020) and higher in the NSAID group than in the non-NSAID groups (47.5 \u00b1 39.5 vs. 15.7 \u00b1 20.0,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study showed that the clinical characteristics of each causative drug group may be different in drug-induced SJS\/TEN. Our findings may help clinicians better understand drug-induced SJS\/TEN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5415\/apallergy.2022.12.e17","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:05:28Z","timestamp":1650845128000},"page":"e17","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Clinical characteristics of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A single-center study"],"prefix":"10.5415","volume":"12","author":[{"given":"Hye Won","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kihyuk","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Heon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Asia Pacific Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/apallergy.org\/pdf\/10.5415\/apallergy.2022.12.e17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/apallergy.org\/DOIx.php?id=10.5415\/apallergy.2022.12.e17","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/10.5415\/apallergy.2022.12.e17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:44:09Z","timestamp":1786387449000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.5415\/apallergy.2022.12.e17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.5415\/apallergy.2022.12.e17","relation":{},"ISSN":["2233-8276"],"issn-type":[{"value":"2233-8276","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}