{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:46:30Z","timestamp":1774950390602,"version":"3.50.1"},"reference-count":0,"publisher":"Radboud University","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TGG"],"abstract":"<jats:p>Abstract\nIntroduction: With the emergence of highly sensitive analytical techniques, biomarkers for Alzheimer\u2019s disease have become measurable in blood. In this literature review, we discuss their diagnostic value based on recent studies.\nMethods: A systematic search was conducted in Embase, PubMed, Web of Science, Cochrane Central, and Google Scholar for studies published from 2021 onwards, using the search terms \u2018Alzheimer\u2019s disease\u2019, \u2018blood biomarkers\u2019, and \u2018memory clinic\u2019.\nResults: Based on the 11 included studies, pTau181, pTau217, NfL, and GFAP appear to be clinically relevant (diagnostic value, AUC &gt; 0.7) as blood biomarkers.\nConclusions: Given their sufficient to very high diagnostic value, certain blood biomarkers may be clinically relevant for diagnostics in a memory clinic setting. However, this conclusion is based on only 11 studies, indicating that further research in representative memory clinic populations is needed.<\/jats:p>","DOI":"10.54195\/tgg24597","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:49:01Z","timestamp":1774946941000},"page":"18","source":"Crossref","is-referenced-by-count":0,"title":["Bloedbiomarkers voor de ziekte van Alzheimer: de klinische waarde op de geheugenpoli","The Clinical Applicability of Blood\u00a0Biomarkers for Alzheimer\u2019s disease in\u00a0the Memory Clinic"],"prefix":"10.54195","volume":"57","author":[{"given":"Marleen","family":"Kloppenburg-Lagendijk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ymkje","family":"Huitema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argonde","family":"Van Harten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth","family":"Hempenius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaas","family":"Verwey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"14109","published-online":{"date-parts":[[2026,3,31]]},"container-title":["Tijdschrift voor Gerontologie en Geriatrie"],"original-title":[],"link":[{"URL":"https:\/\/tvgg.nl\/article\/download\/24597\/27719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/tvgg.nl\/article\/download\/24597\/27719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:49:02Z","timestamp":1774946942000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvgg.nl\/article\/view\/24597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,31]]}},"URL":"https:\/\/doi.org\/10.54195\/tgg24597","relation":{},"ISSN":["1875-6832","0167-9228"],"issn-type":[{"value":"1875-6832","type":"electronic"},{"value":"0167-9228","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,31]]}}}