{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:58:47Z","timestamp":1773223127253,"version":"3.50.1"},"reference-count":0,"publisher":"Radboud University","issue":"2","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["733050835"],"award-info":[{"award-number":["733050835"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005039","name":"Leids Universitair Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TGG"],"abstract":"<jats:p>Background\nThe benefit-harm balance of antihypertensive treatment in older adults with advanced dementia is unclear. This study assesses whether discontinuing antihypertensive treatment reduces neuropsychiatric symptoms (NPS) and maintains quality of life (QoL) in nursing home residents with dementia.\nMethods\nThis outcome-blinded RCT (trial registration: NL7365) randomised Dutch long-term care residents with moderate-to-severe dementia and systolic blood pressure (SBP) \u2264160mmHg during antihypertensive treatment (planned sample size n=492) to either antihypertensive treatment discontinuation (n=101) or usual care (n=104). Outcomes were NPS (Neuropsychiatric Inventory-Nursing Home [NPI-NH]) and QoL (Qualidem) at 16 weeks.\nResults \n205 participants (median age 86 years [IQR 80\u201390]; 79.5% female; median SBP 134mmHg [IQR 123\u2013146]) were included. Randomisation ceased prematurely because of safety concerns, combined with lacking benefits. No significant differences were found between groups for NPI-NH (mean difference 1.6 [95%CI \u20132.3 to 5.6]) or Qualidem (mean difference \u20132.5 [95%CI \u20136.0 to 1.0]). Serious adverse events, such as cardiovascular events or death, occurred in 36% (discontinuation) and 24% (usual care) of the participants (adjusted hazard ratio 1.65 [95%CI 0.98 to 2.79]).\nConclusion\nBecause of the unbeneficial benefit-harm balance, proactive discontinuation of antihypertensive treatment is not recommended in older adults with dementia.\u00a0<\/jats:p>","DOI":"10.54195\/tgg21665","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T08:56:14Z","timestamp":1749545774000},"page":"22","source":"Crossref","is-referenced-by-count":0,"title":["Effecten van het afbouwen van antihypertensiva op neuropsychiatrische symptomen en kwaliteit van leven in verpleeghuisbewoners met dementie (DANTON). Een multicenter, open-label, uitkomst-geblindeerde, gerandomiseerde studie","Effects of the discontinuation of antihypertensive treatment on neuropsychiatric symptoms and quality of life in nursing home residents with dementia (DANTON): a multicentre, open-label, blinded-outcome, randomised controlled trial."],"prefix":"10.54195","volume":"56","author":[{"given":"Jonathan M.K.","family":"Bogaerts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacobijn","family":"Gussekloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca E.M.","family":"De Jong-Schmit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Le Cessie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willeke M.","family":"Ravensbergen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon P.","family":"Mooijaart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilco P.","family":"Achterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalinde K.E.","family":"Poortvliet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"14109","published-online":{"date-parts":[[2025,6,10]]},"container-title":["Tijdschrift voor Gerontologie en Geriatrie"],"original-title":[],"link":[{"URL":"https:\/\/tvgg.nl\/article\/download\/21665\/24993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/tvgg.nl\/article\/download\/21665\/24993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:44:46Z","timestamp":1773146686000},"score":1,"resource":{"primary":{"URL":"https:\/\/tvgg.nl\/article\/view\/21665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,10]]}},"URL":"https:\/\/doi.org\/10.54195\/tgg21665","relation":{},"ISSN":["1875-6832","0167-9228"],"issn-type":[{"value":"1875-6832","type":"electronic"},{"value":"0167-9228","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,10]]}}}