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Several control measures against &lt;i&gt;E. amylovora&lt;\/i&gt; have been reported till date, however, none of them have proved to be effective significantly against the pathogen. In this study, mechanisms of the copper-based control agents (CBCAs): copper oxychloride (COCHL), copper oxide (COX), copper hydroxide (CHY), copper sulfate basic (CSB), and tribasic copper sulfate (TCS) and their disease severity reduction efficacy against &lt;i&gt;E. amylovora&lt;\/i&gt; were analyzed. Bis-1,3-dibutylbarbituric acid trimethine oxonol, carboxyl fluorescein diacetate succinimidyl ester, and 5-cyano-2,3-ditolyl tetrazolium chloride staining were used to check the damage of membrane potential, cytoplasmic pH&lt;sub&gt;in&lt;\/sub&gt;, and respiration of CBCAs-treated &lt;i&gt;E. amylovora&lt;\/i&gt;, respectively. High disturbance in the membrane potential of &lt;i&gt;E. amylovora&lt;\/i&gt; was found under COX and COCHL treatments. Similarly, higher significant changes in the inner cytoplasmic pH&lt;sub&gt;in&lt;\/sub&gt; were observed under COX, COCHL, and TCS treatment. CHY and COCHL-treated &lt;i&gt;E. amylovora&lt;\/i&gt; showed a significant reduction in respiration. &lt;i&gt;In vitro&lt;\/i&gt; bioassay results revealed that CHY, CSB, and TCS at 2,000 ppm reduced the severity of fire blight both in pre- and post-treatment of CBCAs in immature apple fruits and seedlings. Overall, the most effective CBCAs against &lt;i&gt;E. amylovora&lt;\/i&gt; could be CHY at 2,000 ppm as its showed inhibition mechanisms and disease severity reduction.<\/jats:p>","DOI":"10.5423\/ppj.oa.07.2022.0100","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:25:20Z","timestamp":1675297520000},"page":"52-61","update-policy":"https:\/\/doi.org\/10.5423\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Copper-Based Compounds against Erwinia amylovora: Response Parameter Analysis and Suppression of Fire Blight in Apple"],"prefix":"10.5423","volume":"39","author":[{"given":"Duck Kyu","family":"Ryu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9646-8633","authenticated-orcid":true,"given":"Mahesh","family":"Adhikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong 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