{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:18:14Z","timestamp":1793305094585,"version":"4.5.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J Am Acad Orthop Surg","JAAOS"],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:p>Park-Harris lines are radiographically apparent linear opacities that occur in a metaphyseal bone in proximity to a physis. Lines correspond to a temporary interruption of the normally ossifying physis with a sclerotic line corresponding to transversely oriented trabeculae. They were first appreciated in the long bones of diabetic children and have since been described in various metabolic, endocrinologic, infectious, neoplastic, and posttraumatic conditions as well as in response to systemic medications. Park-Harris lines are clinically useful in demarcating notable events in whole-body or individual bone development, in tracking longitudinal growth, or in assessing physeal arrest and responses to its treatment. There remains controversy about whether these lines are pathologic or a component of physiologic development and whether they constitute true \u201cgrowth arrest\u201d or rather \u201cgrowth recovery.\u201d In this review, the history, pathophysiology, imaging, and clinical use of Park-Harris lines as well as an anthropological perspective on their utility for studying illness, nutrition, and historical living conditions over time are discussed.<\/jats:p>","DOI":"10.5435\/jaaos-d-22-00515","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T15:00:08Z","timestamp":1663858808000},"page":"e1483-e1494","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Park-Harris Lines"],"prefix":"10.5435","volume":"30","author":[{"given":"Andrew G.","family":"Georgiadis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.","family":"Gannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"R1-20250524","first-page":"408","article-title":"Hyphenated history: Park-Harris growth arrest lines","volume":"32","author":"Lee","year":"2003","journal-title":"Am J Orthop (Belle Mead NJ)"},{"key":"R2-20250524","first-page":"44","article-title":"Ueber das normale und pathologische wachsthum der r\u00f6hrenknochen","volume":"61","author":"Wegner","year":"1874","journal-title":"Archiv f\u00fcr Pathologische Anatomie und Physiologie und f\u00fcr klinische Medicin"},{"key":"R3-20250524","article-title":"Ueber Wachstum und Architektur der unteren Femurepiphyse und oberen Tibiaepiphyse","author":"Ludloff","year":"1903","journal-title":"Ein Beitrag zur R\u00f6ntgendiagnostik"},{"key":"R4-20250524","first-page":"58","article-title":"Lines and bands of increased density. 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