{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:13:13Z","timestamp":1792177993122,"version":"4.4.0"},"reference-count":1,"publisher":"Physiological Society of Nigeria","issue":"1","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NJPS"],"abstract":"<jats:p>Hibiscus sabdariffa (HS) has gained attention as an anti-hypertensive agent. In the present study, we hypothesized that anthocyanins from HS may attenuate salt-induced hypertension in rats by suppressing the components of renin-angiotensin-aldoslestrone system (RAAS). Hypertension was induced in the rats by adding 8% NaCl in their diet for six weeks. Wistar rats (n=5 each) were randomly divided into seven groups. Group 1 was the normentensive control group and was fed with normal rat chew and water ad libitum; groups 2 and 3 served as hypertensive control (negative untreated and positive treated with captopril 30mg\/kg respectively); groups 4, 5, and 6 served as treatment groups and were administered with graded doses of anthocyanins( 50, 100, 200mg\/kg respectively) while group 7 received both 100mg anthocyanins and 30mg captopril per day for 4 weeks. Using HPLC, anthocyanins were isolated from HS calyx following standard protocol. Anthocyanins significantly (p&lt;0.05) reduced blood pressure and heart rate in hypertensive rats in a dose dependent manner. The blood pressure reduction by anthocyanins was associated with a reduction in serum ACE and plasma aldosterone in the hypertensive rats. The effects of anthocyanins on blood pressure and on biomarkers of RAAS were similar to those of captopril, a reference anti-hypertensive drug. The results suggest that anthocyanins exerts a significant (p&lt;0.05) anti-hypertensive potency on rats, probably mediated by the reduction in components of the RAAS. Keywords: hypertension, anthocyanins, renin, aldosterone, rats<\/jats:p>","DOI":"10.54548\/njps.v37i1.14","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T19:47:56Z","timestamp":1658778476000},"page":"113-117","source":"Crossref","is-referenced-by-count":11,"title":["Anti-Hypertensive Effects of Anthocyanins from Hibiscus sabdarifa Calyx on the Renin-Angiotensin-Aldoslestrone System in Wistar Rats"],"prefix":"10.54548","volume":"37","author":[{"given":"Princewill","family":"Ugwu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruku","family":"Ubom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Madueke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Okorie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nwachukwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"32868","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"41169","unstructured":"Nil"}],"container-title":["Nigerian Journal of Physiological Sciences"],"original-title":[],"link":[{"URL":"https:\/\/ojshostng.com\/index.php\/njphysiologicalsciences\/article\/download\/2292\/1772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojshostng.com\/index.php\/njphysiologicalsciences\/article\/download\/2292\/1772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T19:48:06Z","timestamp":1658778486000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojshostng.com\/index.php\/njphysiologicalsciences\/article\/view\/2292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,30]]},"references-count":1,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,7,25]]}},"URL":"https:\/\/doi.org\/10.54548\/njps.v37i1.14","relation":{},"ISSN":["0794-859X","0794-859X"],"issn-type":[{"value":"0794-859X","type":"electronic"},{"value":"0794-859X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,30]]}}}