{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:18:14Z","timestamp":1754108294936},"reference-count":26,"publisher":"Physiological Society of Nigeria","issue":"1","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NJPS"],"abstract":"<jats:p>Background: Parkinson disease (PD) and Alzheimer\u2019s disease (AD) are progressive neurodegenerative disorders characterized by loss of selective neurons in discreet part of the brain. The peptide angiotensin II (Ang II) plays significant role in hippocampal and striatal neurons degeneration through the generation of reactive oxygen species. Blockade of the angiotensin converting enzyme or ATI receptors provides protection in animal models of neurodegenerative diseases. In the present study, the neuroprotective effect of captopril was investigated in Drosophila melanogaster model using the UAS-GAL4 system to express the synuclein and A\u03b242 peptide in the flies\u2019 neurons.&#x0D;\nMethods: The disease causing human A\u03b242 peptide or \u03b1-syn was expressed pan-neuronally (elav-GAL4) or dopamine neuron (DDC-GAL4) using the UAS-GAL4 system. Flies were either grown in food media with or without captopril (1, 5, or 10\u00b5M). This was followed by fecundity, larva motility, negative geotaxis assay (climbing) and lifespan as a measure of neurodegeneration.&#x0D;\nResults: Elav-Gal4&lt;A\u03b2 or DDC-GAL4&lt;\u03b1-syn flies displayed significant decrease in larva motility when compared with normal control (w1118) which was reversed by the supplementation of the media with captopril (5 or 10 mM) indicative of neuroprotection. Interestingly, supplementation of flies\u2019 media with captopril improved climbing activity in Elav-Gal4&lt;A\u03b2 or DDC-GAL4&lt;\u03b1-syn flies when compared with vehicle treated only. Moreover, flies grown on captopril caused no significant change in lifespan.\u00a0&#x0D;\nConclusion: Findings from this study confirmed the neuroprotective action of captopril in genetic or familial forms of neurodegeneration.<\/jats:p>","DOI":"10.54548\/njps.v37i1.3","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T19:48:01Z","timestamp":1658778481000},"page":"21-28","source":"Crossref","is-referenced-by-count":4,"title":["Angiotensin converting enzyme inhibitor captopril prevents neuronal overexpression of amyloid-beta and alpha-synuclein in Drosophila melanogaster genetic models of neurodegenerative diseases"],"prefix":"10.54548","volume":"37","author":[{"given":"Ismail","family":"Ishola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olasunmbo","family":"Afolayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adedeji","family":"Badru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiwo","family":"Olubodun-obadun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nkechi","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufunmilayo","family":"Adeyemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"32868","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"39786","doi-asserted-by":"crossref","unstructured":"AbdAlla, S., Langer, A., Fu, X., & Quitterer, U (2013). 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