{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:28:59Z","timestamp":1706920139373},"reference-count":0,"publisher":"Physiological Society of Nigeria","issue":"2","license":[{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NJPS"],"abstract":"<jats:p>This study examines the effect of gestational administration of aqueous leaf extract of Jatropha tanjorensis (JT) on postpartum-like behavioural outcomes to delineate its possibility as a prophylactic, therapeutic agent in the treatment of postpartum symptoms. Inseminated female rats (120-150g) were grouped into two-control and JT group (n=10). Control received 20 ml\/kg of distilled water and JT group received 500 mg\/kg of JT orally once daily for 21 days in gestation. Non-pregnant rats were excluded from the study. Parameters assessed at postpartum include antidepressant-like (force swim test, FST; tail suspension-test, TST), locomotor (open field test, OFT), anxiolytic-like (elevated plus maze, EPM; light-dark box, LDB), learning and memory (T-maze; novel object recognition task, NORT), social (nest score) and analgesic-like (hot plate test, HPT; tail flick test, TFT) behaviours. JT increased (P&lt;0.05) mobility and latency to immobility durations in FST and TST; open arm entry (P&lt;0.001) and duration (P&lt;0.01) in EPM and light box duration (P&lt;0.05) in LDB; locomotion and exploration, but reduced anxiety-like levels in EPM, LDB and OFT. It increased nest score (P&lt;0.05); mean retraction time (P&lt;0.01) of TFT. JT showed positive score for short and long term memory in NORT and improved percentage alternation in T-maze though not significant compared to control. In conclusion, the aqueous extract has a therapeutic effect that reduces postpartum-like depression and anxiety, and improves locomotor activity. JT can be a preventive and adjuvant therapeutic option for pregnant women<\/jats:p>","DOI":"10.54548\/njps.v38i2.10","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T11:58:17Z","timestamp":1706875097000},"page":"211-221","source":"Crossref","is-referenced-by-count":0,"title":["Gestational administration of aqueous leaf extract of Jatropha tanjorensis alleviated postpartum emotional and cognitive dysfunction in rats (Wistar strain)"],"prefix":"10.54548","volume":"38","author":[{"given":"Atim","family":"Antai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imoh","family":"Ukoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bisong","family":"Sunday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emem","family":"Edet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Johnny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"32868","published-online":{"date-parts":[[2023,12,31]]},"container-title":["Nigerian Journal of Physiological Sciences"],"original-title":[],"link":[{"URL":"https:\/\/ojshostng.com\/index.php\/njphysiologicalsciences\/article\/download\/2551\/1990","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojshostng.com\/index.php\/njphysiologicalsciences\/article\/download\/2551\/1990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T11:58:18Z","timestamp":1706875098000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojshostng.com\/index.php\/njphysiologicalsciences\/article\/view\/2551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,31]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1,31]]}},"URL":"https:\/\/doi.org\/10.54548\/njps.v38i2.10","relation":{},"ISSN":["0794-859X","0794-859X"],"issn-type":[{"value":"0794-859X","type":"electronic"},{"value":"0794-859X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,31]]}}}