{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:01:21Z","timestamp":1791482481406,"version":"4.3.4"},"reference-count":0,"publisher":"ScopeMed","issue":"2","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":387,"URL":"https:\/\/\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Inform Med"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>Background: Chronic hepatitis B virus (HBV) infection is a global health issue with a significant impact on pregnant women, mainly due to the interplay between liver function and hematological changes. The liver plays a key role in erythropoiesis and systemic hemostasis. In HBeAg-positive pregnant women, platelet dynamics may be uniquely influenced by the interaction of HBV, immune modulation in pregnancy, and liver function. This area remains underexplored. Objective: Our study aimed to analyze the interaction between HbeAg status with others preclinical factors by using the matrix correlation and multidimensional statistics methods. Methods: We used SEM (Structural Equation Modeling) to demonstrate and quantify the direct reciprocal interaction between platelet count and HBeAg status in HBsAg-positive pregnant women. Results: We found the quantity of platelet, with the optimal threshold is 201x10^3cells\/ml, directly relates with HBeAg status (R =0.24) and negatively correlates with ratio of AST on ALT (R=-0.139). In case of HbeAg positive, the risk ratio having a high quantity of platelet (&gt;201x103cells\/ml) and high AST\/ALT ratio (&gt;1.42) is 2.16[1.23,3.80] (p&lt;0.05). SEM model shows that platelet count has a direct impact on HBeAg (p&lt;0.05, Coefficient =0.24) and indirectly through the AST\/ALT ratio. This impact is greater than the direct impact from HBeAg on platelet count (p &lt; 0.05, coefficient = 0.23). Conclusion: Research results show a complex relationship between platelet count, AST\/ALT ratio and HBeAg in patients with chronic hepatitis B. The direct interaction between platelet count, HBeAg status, and AST\/ALT ratio suggests intriguing complex immuno-biochemical responses to chronic hepatitis B virus (HBV) infection.<\/jats:p>","DOI":"10.5455\/aim.2024.32.112-116","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T11:23:24Z","timestamp":1737545004000},"page":"112","source":"Crossref","is-referenced-by-count":1,"title":["Direct Reciprocal Interaction Between Platelet Count and HBeAg Status in HBsAg-positive Pregnant Women"],"prefix":"10.5455","volume":"32","author":[{"given":"Nguyen","family":"Dung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bui","family":"Huong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang","family":"Tram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Acta Informatica Medica"],"original-title":[],"link":[{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/6\/6-1737492533.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:48:17Z","timestamp":1791481697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/6\/6-1737492533.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.5455\/aim.2024.32.112-116","relation":{},"ISSN":["0353-8109"],"issn-type":[{"value":"0353-8109","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}