{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:05:59Z","timestamp":1791486359352,"version":"4.3.4"},"reference-count":0,"publisher":"ScopeMed","issue":"2","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":195,"URL":"https:\/\/bdvets.org\/JAVAR\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Adv Vet Anim Res"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>Objective: The present study investigated the effects of Andaliman fruit extract on tumor necrosis factor-alpha (TNF-\u03b1) and transient receptor potential ankyrin-1 (TRPA-1) levels in type 2 diabetes mellitus (T2DM) mouse models induced with streptozocin (STZ) and a high-fat diet (HFD). \nMaterials and Methods: In this research, mice were allocated into six distinct groups: normal, negative control (HFD and STZ), positive control (metformin, HFD, and STZ), and three treatment groups (HFD, STZ, and Andaliman extract at varying dosages of 100, 300, and 500 mg\/kg, respec\u00actively). Body weight and blood glucose levels (BGLs) were recorded at weeks 1 (baseline), 8, 12, and 16. The levels of TNF-\u03b1 and TRPA-1 were measured during the 16th week. \nResults: Phytochemical screening of the Andaliman extract revealed the presence of flavonoids, alkaloids, tannins, saponins, and glycosides. The one-way ANOVA revealed significantly elevated BGL at week 16 in the negative control group in comparison to the other groups (p &lt; 0.05). The Kruskal-Wallis test followed by Bonferroni-corrected pairwise comparisons showed that the negative control had significantly higher TNF-\u03b1 levels than the Andaliman-groups (z = 22.11, p &lt; 0.01). TRPA-1 was significantly higher in the negative control group compared to the treatment groups (p &lt; 0.05). Furthermore, Spearman\u2019s rho analysis revealed a statistically significant positive associ\u00acation between BGL and both TNF-\u03b1 and TRPA-1, as well as between TNF-\u03b1 and TRPA. \nConclusion: Andaliman extract potentially serves as a therapy for diabetic neuropathy in T2DM by lowering BGL and inhibiting the expression of TNF-\u03b1 and TRPA-1.<\/jats:p>","DOI":"10.5455\/javar.2024.k774","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T05:30:55Z","timestamp":1720935055000},"page":"284","source":"Crossref","is-referenced-by-count":3,"title":["The effect of Andaliman (Zanthoxylum acanthopodium DC.) fruit extracted with ethanol on TNF-\u03b1 and TRPA-1 levels in type II diabetes-induced mice"],"prefix":"10.5455","volume":"11","author":[{"given":"Boyke","family":"Simbolon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OK","family":"Yulizal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hutapea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Handoko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Journal of Advanced Veterinary and Animal Research"],"original-title":[],"link":[{"URL":"https:\/\/ejmanager.com\/mnstemps\/39\/39-1694965624.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:02:18Z","timestamp":1791482538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/39\/39-1694965624.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.5455\/javar.2024.k774","relation":{},"ISSN":["2311-7710"],"issn-type":[{"value":"2311-7710","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}