{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:06:20Z","timestamp":1791486380482,"version":"4.3.4"},"reference-count":0,"publisher":"ScopeMed","issue":"1","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":111,"URL":"https:\/\/bdvets.org\/JAVAR\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Adv Vet Anim Res"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Objective: The goal of this study is to describe the genome of &lt;i&gt;Streptococcus agalactiae&lt;\/i&gt; that was found in clinical mastitis in cattle in Bangladesh. This work will show how strong the bacteria are and how important they are for public health. \nMaterials and Methods: Whole genome sequencing (WGS) was performed using the Illumina MiSeq platform, followed by comprehensive analysis with various bioinformatic tools to identify key genomic features. \nResults: WGS revealed that the isolates are closely related, belonging to sequence type ST4, a rare type previously identified in both human and animal hosts. The isolates possess 44 viru-lence-related genes linked to adherence, capsule biogenesis, enzyme production, immunoreac-tive antigens, protease, and cytolysin production. They also carry two pilus islands (PIs), PI-1 and PI-2b, which are often associated with invasive diseases. PI-2b proteins are key targets for vaccine development against Group B Streptococcus (GBS). The isolates belong to serotype Ia and carry the gbs2018-2 variant, indicating their adaptability to a wide range of hosts, including humans and animals. These virulence factors are critical for understanding &lt;i&gt;S. agalactiae&lt;\/i&gt;\u2019s pathogenicity and developing vaccines against its infections. Additionally, the isolates harbor antimicrobial resistance genes conferring resistance to glycopeptides (&lt;i&gt;vanT&lt;\/i&gt;, &lt;i&gt;vanY&lt;\/i&gt;), macrolides (&lt;i&gt;mreA&lt;\/i&gt;), peptides (&lt;i&gt;mprF&lt;\/i&gt;), penicillins and &lt;i&gt;\u03b2&lt;\/i&gt;-lactams (&lt;i&gt;pbp&lt;\/i&gt;), and aminoglycosides. Source tracking via the BacWGSTdb website identified these isolates as closely related to human pathogens, indicating their zoonotic potential. \nConclusion: These results suggest that &lt;i&gt;S. agalactiae&lt;\/i&gt; could be a zoonotic pathogen. This highlights the need for ongoing genomic surveillance to fully understand how it causes disease and come up with effective ways to control it.<\/jats:p>","DOI":"10.5455\/javar.2025.l874","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T18:11:12Z","timestamp":1745345472000},"page":"80","source":"Crossref","is-referenced-by-count":1,"title":["Genomic features and pathogenic potential of Streptococcus agalactiae isolated from bovine clinical mastitis."],"prefix":"10.5455","volume":"12","author":[{"given":"Jayedul","family":"Hassan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdus","family":"Bag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmita","family":"Karmakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishor","family":"Utsho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wohab","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajran","family":"Kabir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvir","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Journal of Advanced Veterinary and Animal Research"],"original-title":[],"link":[{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/39\/39-1722774752.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:02:37Z","timestamp":1791482557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/39\/39-1722774752.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5455\/javar.2025.l874","relation":{},"ISSN":["2311-7710"],"issn-type":[{"value":"2311-7710","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}