{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:06:37Z","timestamp":1791486397686,"version":"4.3.4"},"reference-count":0,"publisher":"ScopeMed","issue":"3","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":309,"URL":"https:\/\/bdvets.org\/JAVAR\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Adv Vet Anim Res"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>&lt;b&gt;Objective:&lt;\/b&gt; This study examines the neuroprotective and anticonvulsant effects of quercetin on pentylenetetrazol (PTZ)-induced convulsive seizures in chicks.\n&lt;b&gt;Materials and Methods:&lt;\/b&gt; Sixty Ross broiler chicks were randomly assigned to six groups: a negative control, a positive control treated with PTZ at 80 mg\/kg, a diazepam-treated group (5 mg\/kg), and three quercetin-treated groups receiving 50, 100, and 200 mg\/kg orally for six consecutive days, respectively. Two hours after the final dose, PTZ was administered to groups 3-6 to induce seizures. The onset of convulsions and mortality rates were recorded over a period of 3 h. Brain tissue was collected to determine biochemical parameters, malondialdehyde (MDA), total antioxidant capacity (TAO-C), interleukin-1\u03b2 (IL-1\u03b2), and tumor necrosis factor-\u03b1 (&lt;i&gt;TNF-\u03b1&lt;\/i&gt;).\n&lt;b&gt;Results:&lt;\/b&gt; The delay in the onset of convulsions and survival improvement were found in quercetin pretreatment in a dose-dependent manner. The highly significant survival was found at 200 mg\/ kg (&lt;i&gt;p&lt;\/i&gt; &lt; 0.001), and moderately at 50 and 100 mg\/kg (&lt;i&gt;p&lt;\/i&gt; &lt; 0.05). MDA (&lt;i&gt;p &lt;\/i&gt;&lt; 0.05) and &lt;i&gt;TNF-\u03b1&lt;\/i&gt; (&lt;i&gt;p&lt;\/i&gt; &lt; 0.01) levels were significantly decreased at all doses. TAO-C levels were significantly elevated, while IL-1\u03b2 levels declined at 200 mg\/kg (&lt;i&gt;p&lt;\/i&gt; &lt; 0.05).\nConclusion: Quercetin pretreatment at 200 mg\/kg showed antioxidant and anti-inflammatory potential against PTZ-induced convulsive seizure as a preventive therapy for epilepsy management.<\/jats:p>","DOI":"10.5455\/javar.2025.l963","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:46:08Z","timestamp":1762451168000},"page":"1037","source":"Crossref","is-referenced-by-count":1,"title":["Quercetin attenuates pentylenetetrazol-induced seizures in chicks through antioxidant and anti-inflammatory pathways"],"prefix":"10.5455","volume":"12","author":[{"given":"Suleiman","family":"Suleiman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karwan","family":"Jarjees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziza","family":"Haji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Journal of Advanced Veterinary and Animal Research"],"original-title":[],"link":[{"URL":"https:\/\/www.bibliomed.org\/fulltextpdf.php?mno=262203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:02:53Z","timestamp":1791482573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bibliomed.org\/?mno=262203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5455\/javar.2025.l963","relation":{},"ISSN":["2311-7710"],"issn-type":[{"value":"2311-7710","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}