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Indigenous king of bitter ( Andrographis paniculata ): A review. J Med Plant"},{"key":"ref2","unstructured":"Stud 2017; 5(2):318\u201324. [ Source , accessed on July 24, 2025]"},{"key":"ref3","unstructured":"[2] Ardika RG, Budiono BP , Widiastiti YS, Maharani N, Susilaningsih N, Sandra F. Andrographis paniculate  leaves extract inhibit TNF-\u03b1  and caspase-3"},{"key":"ref4","unstructured":"expression of septic rats intestinal tissues. Indones Biomed J 2024; 16(1):1\u201393. [ Crossref ]"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"[3] Yang Y, Fang LD, Du GH. Andrographolide. In: Natural small molecule drugs from plants. Springer, Singapore, pp. 357\u201362, 2018. [ Crossref ]","DOI":"10.1007\/978-981-10-8022-7_60"},{"key":"ref6","unstructured":"[4] Jaidee W, Rujanapun N, Malee K, Chaisawandi S, Puttarak P , Hiransai P , et al. Degradation kinetics of andrographolide in aqueous solution,"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"product identification and biological activity evaluation. Sci Rep 2025; 15:28856. [ Crossref ]","DOI":"10.1038\/s41598-025-13652-6"},{"key":"ref8","unstructured":"[5] Al-Garadi MA, Alhotan RA, Fazea EH, Hussein EO, Qaid MM, Suliman GM, et al. Effects of a natural phytogenic feed additive on broiler performance,"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"carcass traits, and gut health under diets with optimal and reduced energy and amino acid density. Poult Sci 2025; 104(10):105014. [ Crossref ]","DOI":"10.1016\/j.psj.2025.105014"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"[6] Sampath V, Kim LH. Glimpse of functional feed additives for sustainable broiler production \u2013 a review. J Anim Feed Sci 2025; 34(3):341\u201355.","DOI":"10.22358\/jafs\/202264\/2025"},{"key":"ref11","unstructured":"[Crossref ]"},{"key":"ref12","unstructured":"[7] Freitas LFVB, Sakomura NK, Reis MP , Mariani AB, Lambert W, Andretta I, et al. Coccidiosis infection and growth performance of broilers in"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"experimental trials: Insights from a meta-analysis including modulating factors. Poult Sci 2023; 102(11):103021. [ Crossref ]","DOI":"10.1016\/j.psj.2023.103021"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"[8] Blake DP , Knox J, Dehaeck B, Huntington B, Rathinam T , Ravipati V, et al. Re-calculating the cost of coccidiosis in chickens. Vet Res 2020; 51:115.","DOI":"10.1186\/s13567-020-00837-2"},{"key":"ref15","unstructured":"[Crossref ]"},{"key":"ref16","unstructured":"[9] Mathis GF, Lumpkins B, Cervantes HM, Fitz-Coy SH, Jenkins MC, Jones MK, et al. Coccidiosis in poultry: Disease mechanisms, control strategies,"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"and future directions. Poult Sci 2025; 104(5):104663. [ Crossref ]","DOI":"10.1016\/j.psj.2024.104663"},{"key":"ref18","unstructured":"[10] Qaid MM, Al-Mufarrej SI, Azzam MM, Al-Garadi MA. Anticoccidial effectivity of a traditional medicinal plant, Cinnamomum verum , in broiler"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"chickens infected with Eimeria tenella . Poult Sci 2021; 100(3):100902. [ Crossref ]","DOI":"10.1016\/j.psj.2020.11.071"},{"key":"ref20","unstructured":"[11] Shirley MW. Maintenance in animal hosts: Eimeria  species and strains of chickens. Contributions to biotechnology guideline on techniques."},{"key":"ref21","unstructured":"European Commission, Brussels-Luxembourg, pp. 1\u201323, 1995."},{"key":"ref22","unstructured":"[12] Nawarathne SR, Yu M, Heo JM. Poultry coccidiosis: A concurrent overview on etiology, diagnostic practices, and preventive measures. Korean J"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Poult Sci 2021; 48(4):297\u2013318. [ Crossref ]","DOI":"10.5536\/KJPS.2021.48.4.297"},{"key":"ref24","unstructured":"[13] Chang LYD, Xu KQ, Chen J, Fan Y, Zhong XJ, Wang DH, et al. Effect of natural garlic essential oil on chickens with artificially infected Eimeria tenella ."},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Vet Parasitol 2021; 300:109614. [ Crossref ]","DOI":"10.1016\/j.vetpar.2021.109614"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"[14] Johnson J, Reid WM. Anticoccidial drugs: Lesion scoring techniques in battery and floor-pen experiments with chickens. Exp Parasitol 1970;","DOI":"10.1016\/0014-4894(70)90063-9"},{"key":"ref27","unstructured":"28(1):30\u20136. [ Crossref ]"},{"key":"ref28","unstructured":"[15] Long PL, Reid WM. A guide for diagnosis of coccidiosis in chickens. Contributions to Research Report 404. The University of Georgia College of"},{"key":"ref29","unstructured":"Agriculture Experiment Stations, Athens, Georgia, USA, pp. 1\u201317, 1982. [ Source , accessed on July 30, 2025]"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"www.bdvets.org\/javar Wijayanti et al.  \/ J Adv Vet Anim Res, 13(1): 332\u2013339, March 2026 339","DOI":"10.5455\/javar.2026.m1035"},{"key":"ref31","unstructured":"[16] Qidong Z, Peng S, Bingkun Z, Ling K, Chuanpi X, Zhigang S. Progress on gut health maintenance and antibiotic alternatives in broiler chicken"},{"key":"ref32","unstructured":"production. Front Nutr 2021; 8:692839. [ Crossref ]"},{"key":"ref33","unstructured":"[17] Abd El-Hack ME, El-Saadony MT , Salem HM, El-Tahan AM, Soliman MM, Youssef GBA, et al. Alternatives to antibiotics for organic poultry"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"production: Types, modes of action and impacts on bird\u2019s health and production. Poult Sci 2022; 101(4):101696. [ Crossref ]","DOI":"10.1016\/j.psj.2022.101696"},{"key":"ref35","unstructured":"[18] Reda FM, El-Saadony MT , El-Rayes TK, Attia AI, El-Sayed SA, Ahmed SY, et al. Use of biological nano zinc as a feed additive in quail nutrition:"},{"key":"ref36","unstructured":"Biosynthesis, antimicrobial activity and its effect on growth, feed utilization, blood metabolites and intestinal microbiota. Ital J Anim Sci 2021;"},{"key":"ref37","unstructured":"20(1):324\u201335. [ Crossref ]"},{"key":"ref38","unstructured":"[19] Polycarpo GV, Andretta I, Kipper M, Cruz-Polycarpo VC, Dadalt JC, Rodrigues PHM, et al. Meta-analytic study of organic acids as an alternative"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"performance-enhancing feed additive to antibiotics for broiler chickens. Poult Sci 2017; 96(10):3645\u201353. [ Crossref ]","DOI":"10.3382\/ps\/pex178"},{"key":"ref40","unstructured":"[20] Andrew SL, Mohammed HZ, Manyelo TG, Mabelebele M. The current status of the alternative use to antibiotics in poultry production: An African"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"perspective. Antibiotics 2020; 9(9):594. [ Crossref ]","DOI":"10.3390\/antibiotics9090594"},{"key":"ref42","unstructured":"[21] Alagawany MT , El-Saadony SS, Elnesr M, Farahat G, Attia M, Madkour FM, et al. Use of lemongrass essential oil as a feed additive in quail\u2019s"},{"key":"ref43","unstructured":"nutrition: its effect on growth carcass, blood biochemistry, antioxidant and immunological indices, digestive enzymes and intestinal microbiota."},{"key":"ref44","unstructured":"Poult Sci 2021; 100(6):101172. [ Crossref ]"},{"key":"ref45","unstructured":"[22] Hasanain IF, Sjofjan O, Nuningtyas YF, Marwi F, Hermanto FE, Handoyo YS, et al. Effect of nano-liquid extract of Andrographis paniculata  and"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Moringa oleifera  on the performance and carcass quality of broiler chickens. World Vet J 2024; 14(3):400\u20138. [ Crossref ]","DOI":"10.54203\/scil.2024.wvj47"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"[23] Irianti IN, Wijayanti AD, Mulyani GT . The anticoccidial property of sambiloto ( Andrographis paniculata ) leaf extract. Indones J Vet Sci 2022;","DOI":"10.22146\/ijvs.v3i1.85442"},{"key":"ref48","unstructured":"3(1):8\u201313. [ Crossref ]"},{"key":"ref49","unstructured":"[24] Vilien\u0117 V, Racevi\u010di\u016bt\u0117-Stupelien\u0117 A, Murawska D, Gesek M, Matusevi\u010dius P , Miknien\u0117 Z, et al. Evaluation of herbal anticoccidials on growth"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"performance in experimentally infected broiler chickens. Agriculture 2024; 14(12):2261. [ Crossref ]","DOI":"10.3390\/agriculture14122261"},{"key":"ref51","unstructured":"[25] Tongkamsai S, Boobphahom S, Apphaicha R, Chansiripornchai N. Prevalence and anticoccidial drug sensitivity of Eimeria tenella  isolated from"},{"key":"ref52","unstructured":"commercial broiler farms in Thailand. Vet World 2025; 18(6):1561\u201370. [ Crossref ]"},{"key":"ref53","unstructured":"[26] Lopez-Ozorio S, Chaparro-Gutierrez JJ, Gomez-Osorio LM. Overview of poultry Eimeria  life cycle and host-parasite interaction. Front Vet Sci"},{"key":"ref54","unstructured":"2020; 7:384. [ Crossref ]"},{"key":"ref55","unstructured":"[27] Hadidi M, Linan-Atero R, Tarahi M, Christodoulou MC, Aghababaei F. The potential health benefit of gallic acid: Therapeutic and food applications."},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Antioxidants 2024; 13(8):1001. [ Crossref ]","DOI":"10.3390\/antiox13081001"},{"key":"ref57","unstructured":"[28] De-Veras BO, da-Silva MV, Ribiero PPC. Tannic acid is a gastroprotective that regulates inflammation and oxidative stress. Food Chem Toxicol"},{"key":"ref58","unstructured":"2021; 156:12482. [ Crossref ]"},{"key":"ref59","unstructured":"[29] Ozogul Y, Yilmaz U, Eskindir ET , Nikheel R, Piotr K, Monica T , et al. Tannins for food preservation and human health: A review of current"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"knowledge. Appl Food Res 2025; 5(1):100738. [ Crossref ]","DOI":"10.1016\/j.afres.2025.100738"},{"key":"ref61","unstructured":"[30] Mesa-Pineda C, Navarro-Ru\u00edz JL, L\u00f3pez-Osorio S, Chaparro-Guti\u00e9rrez JJ, G\u00f3mez-Osorio LM. Chicken coccidiosis: From the parasite lifecycle to"},{"key":"ref62","unstructured":"control of the disease. Front Vet Sci 2021; 8:787653. [ Crossref ]"},{"key":"ref63","unstructured":"[31] Miura K, Swihart BJ, Deng B, Zhou L, Pham TP , Diouf A, et al. Strong concordance between percent inhibition in oocyst and sporozoite intensities"},{"key":"ref64","unstructured":"in a Plasmodium falciparum  standard membrane-feeding assay. Parasit Vectors 2019; 12:206. [ Crossref ]"},{"key":"ref65","unstructured":"[32] Bortoluzzi C, Phillips AJ, Coweison SM, Ramirez SM, Lumpkins B, Mathis G. Coccidiosis in chickens: From temporal patterns of lesion development"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"and oocyst shedding to predictive modelling. Poult Sci 2025; 104(11):105750. [ Crossref ]","DOI":"10.1016\/j.psj.2025.105750"},{"key":"ref67","unstructured":"[33] Abebe E, Gugsa G. A review on poultry coccidiosis. Abyssinia J Sci Technol 2018; 3(1):1\u201312. [ Source , accessed on August 10, 2025]"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"[34] Ahmad R, Yu YH, Hua KF, Chen WJ, Zaborski D, Dybus A, et al. Management and control of coccidiosis in poultry - A review. Anim Biosci 2024;","DOI":"10.5713\/ab.23.0189"},{"key":"ref69","unstructured":"37(1):1\u201315. [ Crossref ]"},{"key":"ref70","unstructured":"[35] Kadykalo S, Roberts T , Thompson M, Wilson J, Lang M, Espeisse O. The value of anticoccidials for sustainable global poultry production. Int J"},{"key":"ref71","unstructured":"Antimicrob Agents 2018; 51(3):304\u201310. [ Crossref ]"},{"key":"ref72","unstructured":"[36] Al-Quraishy S, Qasem MA, Ak-Shaebi EM, Murshed M, Mare MM, Dkhil MA. Rumex nervosus  changed the oxidative status of chicken caecum"},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"infected with Eimeria tenella . J King Saud Univ Sci 2020; 32(3):2207\u201311. 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