{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:10:30Z","timestamp":1791486630153,"version":"4.3.4"},"reference-count":54,"publisher":"ScopeMed","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.matersociomed.org\/\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.5455\/msm.2019.31.166-171","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T16:16:12Z","timestamp":1569255372000},"source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of Lysozyme, Cetylpyridinium and Lidocaine Fixed Combination for Treatment of Chemotherapy- and Radiotherapy-Induced Oral Mucositis: a Pilot Study"],"prefix":"10.5455","member":"3407","reference":[{"key":"ref1","unstructured":"1. Cidon EU. Chemotherapy induced oral mucositis: prevention"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"is possible. Chin Clin Oncol. 2018; 7(1): 6.","DOI":"10.21037\/cco.2017.10.01"},{"key":"ref3","unstructured":"2. Maria OM, Eliopoulos N, Muanza T. Radiation-Induced Oral"},{"key":"ref4","unstructured":"Mucositis. Front Oncol. 2017; 7: 89."},{"key":"ref5","unstructured":"3. Pereira IF, Firmino RT, Meira HC, DO Egito Vasconcelos BC,"},{"key":"ref6","unstructured":"DE Souza Noronha VRA, Santos VR. Radiation-induced Oral"},{"key":"ref7","unstructured":"Mucositis in Brazilian Patients: Prevalence and Associated"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Factors. Vivo Athens Greece. 2019; 33(2): 605-609.","DOI":"10.21873\/invivo.11517"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"171 Mater Sociomed. 2019 Sep; 31(3): 166-171 \u2022 ORIGINAL PAPER Efficacy and Safety of Lysozyme, Cetylpyridinium and Lidocaine Fixed Combination for Treatment of Chemotherapy","DOI":"10.5455\/msm.2019.31.166-171"},{"key":"ref10","unstructured":"4. Piredda M, Facchinetti G, Biagioli V, Giannarelli D, Armento"},{"key":"ref11","unstructured":"G, Tonini G, et al. Propolis in the prevention of oral mucositis"},{"key":"ref12","unstructured":"in breast cancer patients receiving adjuvant chemotherapy:"},{"key":"ref13","unstructured":"A pilot randomised controlled trial. Eur J Cancer Care (Engl)."},{"key":"ref14","unstructured":"2017; 26(6)."},{"key":"ref15","unstructured":"5. Blakaj A, Bonomi M, Gamez ME, Blakaj DM. Oral mucositis"},{"key":"ref16","unstructured":"in head and neck cancer: Evidence-based management and"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"review of clinical trial data. Oral Oncol. 2019; 95: 29-34.","DOI":"10.1016\/j.oraloncology.2019.05.013"},{"key":"ref18","unstructured":"6. Mallick S, Benson R, Rath GK. Radiation induced oral mucosi -"},{"key":"ref19","unstructured":"tis: a review of current literature on prevention and manage -"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"ment. Eur Arch OtoRhinoLaryngol. 2016; 273(9): 2285-2293.","DOI":"10.1007\/s00405-015-3694-6"},{"key":"ref21","unstructured":"7. Ragland SA, Criss AK. From bacterial killing to immune"},{"key":"ref22","unstructured":"modulation: Recent insights into the functions of lysozyme."},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"PLoS Pathog. 2017; 13(9): e1006512.","DOI":"10.1371\/journal.ppat.1006512"},{"key":"ref24","unstructured":"8. Gratkowska H, Kozlowska I, Szymczyk T. Lysozyme in the"},{"key":"ref25","unstructured":"treatment of recurrent aphthous stomatitis (preliminary"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"report). Czas Stomatol. 1972; 25(5): 437-440.","DOI":"10.12935\/jvma1951.25.437"},{"key":"ref27","unstructured":"9. Tsepeleva AS. Use of lysozyme in the treatment of chronic"},{"key":"ref28","unstructured":"relapsing aphthous stomatitis. Stomatologiia (Sofiia)."},{"key":"ref29","unstructured":"1975;54(6):15\u20138."},{"key":"ref30","unstructured":"10. Shao Y, Zhou H. Clinical evaluation of a toothpaste contain -"},{"key":"ref31","unstructured":"ing lysozyme for the treatment of recurrent aphthous sto -"},{"key":"ref32","unstructured":"matitis: A 3-month, double-blind, randomized study. Am J"},{"key":"ref33","unstructured":"Dent. 2016; 29(6): 303-306. 11. Lalla RV, Saunders DP, Peterson DE. Chemotherapy or ra -"},{"key":"ref34","unstructured":"diation-induced oral mucositis. Dent Clin North Am. 2014;"},{"key":"ref35","unstructured":"58(2): 341-349."},{"key":"ref36","unstructured":"12. He M, Zhang B, Shen N, Wu N, Sun J. A systematic review and"},{"key":"ref37","unstructured":"meta-analysis of the effect of low-level laser therapy (LLLT)"},{"key":"ref38","unstructured":"on chemotherapy-induced oral mucositis in pediatric and"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"young patients. Eur J Pediatr. 2018; 177(1): 7\u201317.","DOI":"10.1007\/s00431-017-3043-4"},{"key":"ref40","unstructured":"13. Co JL, Mejia MBA, Que JC, Dizon JMR. Effectiveness of"},{"key":"ref41","unstructured":"honey on radiation-induced oral mucositis, time to muco -"},{"key":"ref42","unstructured":"sitis, weight loss, and treatment interruptions among pa -"},{"key":"ref43","unstructured":"tients with head and neck malignancies: A meta-analysis"},{"key":"ref44","unstructured":"and systematic review of literature. Head Neck. 2016; 38(7):"},{"key":"ref45","unstructured":"14. Catic T, Mehic M, Binakaj Z, Sahman B, Cordalija V, Kerla"},{"key":"ref46","unstructured":"A, et al. Efficacy and Safety of Oral Spray Containing Ly -"},{"key":"ref47","unstructured":"sozyme and Cetylpyridinium: Subjective Determination of"},{"key":"ref48","unstructured":"Patients with Tonsillopharyngitis. Mater Sociomed. 2016;"},{"key":"ref49","unstructured":"28(6): 459-463."},{"key":"ref50","unstructured":"15. Ohbayashi H, Setoguchi Y, Fukuchi Y, Shibata K, Sakata Y,"},{"key":"ref51","unstructured":"Arai T. Pharmacological effects of lysozyme on COPD and"},{"key":"ref52","unstructured":"bronchial asthma with sputum: A randomized, placebo-"},{"key":"ref53","unstructured":"controlled, small cohort, cross-over study. Pulm Pharmacol"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Ther. 2016; 37: 73-80.","DOI":"10.2307\/j.ctv1xx9b4x.10"}],"container-title":["Materia Socio Medica"],"original-title":[],"link":[{"URL":"https:\/\/ejmanager.com\/mnstemps\/16\/16-1569263392.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:07:38Z","timestamp":1791482858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/16\/16-1569263392.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":54,"URL":"https:\/\/doi.org\/10.5455\/msm.2019.31.166-171","relation":{},"ISSN":["1512-7680"],"issn-type":[{"value":"1512-7680","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}