{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:29:58Z","timestamp":1794324598449,"version":"4.9.0"},"reference-count":0,"publisher":"ScopeMed","issue":"2","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":149,"URL":"https:\/\/matersociomed.org\/\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mater Sociomed"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: Psoriasis, a common skin disorder, involves immune cells and cytokines in its pathogenesis. Narrow band ultraviolet B (NB-UVB) treatment has demonstrated efficacy and safety in managing this condition. Objective: This study aimed to assess changes in serum interleukin (IL)-17, IL-23, and tumor necrosis factor-alpha (TNF-\u03b1) levels during NB-UVB treatment for psoriasis vulgaris. Methods: An interventional, pre-post comparative study was conducted on patients with moderate to severe psoriasis vulgaris undergoing NB-UVB treatment. Patients were randomly allocated to Group 1 (n=39) receiving NB-UVB based on minimal erythema dose (MED) and Group 2 (n=32) based on Fitzpatrick skin type classification. Serum IL-17, IL-23, and TNF-\u03b1 levels were measured before treatment and upon achieving PASI75. Results: There were no significant differences in serum IL-17, IL-23, and TNF-\u03b1 levels between Group 1 and Group 2 at either time point. In Group 1, IL-17 levels decreased from median 2.6 pg\/ml before treatment to 2.5 pg\/ml at PASI75 (P=0.0107). In Group 2, IL-23 levels decreased from median 9.6 pg\/ml pre-treatment to 1.3 pg\/ml at PASI75 (P&lt;0.0190). Across all patients, pre-treatment IL-17 and IL-23 levels (median 2.6 pg\/ml and 7.1 pg\/ml, respectively) were significantly higher compared to levels at PASI75 (P=0.0349 and P=0.0023, respectively). Conclusion: NB-UVB effectively treats moderate to severe psoriasis vulgaris, leading to reduced serum IL-17 and IL-23 levels irrespective of MED-based or skin type-based dosing strategies.<\/jats:p>","DOI":"10.5455\/msm.2025.37.125-130","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T03:56:37Z","timestamp":1748577397000},"page":"125","source":"Crossref","is-referenced-by-count":3,"title":["Reduction of Serum Interleukin-17 and Interleukin-23 Levels Following Narrow Band Ultraviolet B Treatment in Patients with Moderate-to-severe Psoriasis Vulgaris"],"prefix":"10.5455","volume":"37","author":[{"given":"Pham","family":"Phuong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran","family":"Huyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quach","family":"Giang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinh","family":"Trang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang","family":"Phuong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Thuong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Doanh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Materia Socio Medica"],"original-title":[],"link":[{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/16\/16-1748545464.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:08:27Z","timestamp":1791482907000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/16\/16-1748545464.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5455\/msm.2025.37.125-130","relation":{},"ISSN":["1512-7680"],"issn-type":[{"value":"1512-7680","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}