{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:30:49Z","timestamp":1794324649756,"version":"4.9.0"},"reference-count":0,"publisher":"ScopeMed","issue":"4","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":114,"URL":"https:\/\/www.openveterinaryjournal.com\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Vet J"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Background: \nIn 2015, an unprecedented epidemic of microcephaly occurred in Brazil. Preliminary observations suggested involvement of cofactors in the etiopathology of Zika virus associated microcephaly. Bovine viral diarrhea virus (BVDV) was identified in fetal samples with microcephaly, originating in the state of Para\u00edba, and two virus sequences, obtained from the amniotic fluid collected from mothers with babies affected by Zika and microcephaly, have been characterized as two different species of BVDV, types 1 and 2. \nAim: \nThe involvement of BVDV as co-factor in the etiopathogenesis of Zika virus associated microcephaly was explored.\nMethods: \nA serological screening using an ELISA test was undertaken to detect antibodies against BVDV among patients referred to the Central laboratory of Natal, Rio Grande do Norte, encompassing microcephalic babies and their mothers, mothers and pregnant not associated with microcephaly and general patients as control group. \nResults: \nTwo samples were positive, out of 382 tested, (0.52%). No specific relation with birth-defects could be established. \nConclusion: \nThe study might suggest serological evidence of the circulation of BVDV in humans. Further studies and application of improved diagnostic tests adapted to humans are necessary to clarify the epidemiological extent and impact of BVDV.<\/jats:p>","DOI":"10.5455\/ovj.2023.v13.i4.1","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T07:57:34Z","timestamp":1682409454000},"page":"400","source":"Crossref","is-referenced-by-count":2,"title":["Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly"],"prefix":"10.5455","volume":"13","author":[{"given":"Massimo","family":"Giangaspero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamaki","family":"Okabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Open Veterinary Journal"],"original-title":[],"link":[{"URL":"https:\/\/ejmanager.com\/mnstemps\/100\/100-1669792224.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:16:01Z","timestamp":1791483361000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/100\/100-1669792224.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.5455\/ovj.2023.v13.i4.1","relation":{},"ISSN":["2226-4485"],"issn-type":[{"value":"2226-4485","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}