{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:30:53Z","timestamp":1794324653767,"version":"4.9.0"},"reference-count":0,"publisher":"ScopeMed","issue":"7","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"vor","delay-in-days":216,"URL":"https:\/\/www.openveterinaryjournal.com\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Vet J"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>Background: \nPrognostic factors in dogs with nasal tumors include several variables. However, factors that can measure prognosis have not yet been identified due to considerable divergence among reports. \nAim: \nTo describe the computed tomography (CT) imaging, treatment, and outcomes of dogs with nasal tumors, as well as detect negative prognostic factors through the analysis of a substantial number of cases from a single institution. Furthermore, based on CT findings, this study aimed to identify independent prognostic factors for nasal tumors in dogs.\nMethods: \nA total of 166 client-owned dogs were diagnosed with nasal tumors at Gifu University Veterinary Hospital between 2015 and 2019. Data were retrospectively collected from the electronic medical records.\nResults: \nUnivariate analysis revealed a significant difference in survival time between adenocarcinoma and squamous cell carcinoma in 166 canine nasal tumors treated with megavoltage radiation therapy at a single institution (p= .015). There was a significant difference in survival time between carcinoma and sarcoma (p= .04). Regarding CT imaging findings, significant differences in survival time were observed for frontal sinus invasion (p= .007), cribriform plate destruction (p&lt; .001), and lymph node metastasis (p= .003). Multivariate Cox regression analysis was performed to assess frontal sinus invasion, cribriform plate destruction, histopathologic subtypes, and lymph node metastasis as negative prognostic factors; however, only cribriform plate destruction was a significant negative prognostic factor for survival time (p= .004).\nConclusion: \nMultivariate Cox regression analysis showed that cribriform plate destruction was the main factor in predicting a negative prognosis among 166 canine nasal tumors treated with megavoltage radiation therapy at a single institution. Therefore, we propose a new 2-tier staging classification for canine nasal tumors with the presence or absence of cribriform plate destruction based on CT examination as the only evaluation factor.<\/jats:p>","DOI":"10.5455\/ovj.2024.v14.i7.3","type":"journal-article","created":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T18:06:22Z","timestamp":1722794782000},"page":"1538","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic factors and survival following radiation therapy for canine nasal tumors: A single-institution retrospective study of 166 cases"],"prefix":"10.5455","volume":"14","author":[{"given":"Rui","family":"Mizuno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Open Veterinary Journal"],"original-title":[],"link":[{"URL":"https:\/\/ejmanager.com\/mnstemps\/100\/100-1704525235.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:17:08Z","timestamp":1791483428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/100\/100-1704525235.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.5455\/ovj.2024.v14.i7.3","relation":{},"ISSN":["2226-4485"],"issn-type":[{"value":"2226-4485","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}