{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:30:58Z","timestamp":1794324658168,"version":"4.9.0"},"reference-count":0,"publisher":"ScopeMed","issue":"0","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":68,"URL":"https:\/\/www.openveterinaryjournal.com\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Vet J"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: \nDespite an initial favorable response to hypofractionated radiotherapy (RT), intranasal neoplasia has a poor long-term prognosis. Re-irradiation (re-RT) has been shown to result in clinical remission in dogs with recurrent intranasal tumors. Hypofractionated re-RT is indicated in cases of recurrence. \n\nAim: \nThis study aimed to investigate the response of patients with recurrent intranasal tumors who were initially treated with repeated hypofractionated RT. \n\nMethods: \nMedical records of dogs with intranasal tumors that relapsed after undergoing hypofractionated RT at Azabu University Veterinary Teaching Hospital and who underwent re-RT between 2008 and 2022 were retrospectively analyzed.\n\nResults: \nAmong the 30 dogs included, 20 had adenocarcinomas. Eleven patients underwent second re-irradiation, and five patients underwent third re-irradiation. The median total isocenter dose and total number of fractions were 56 Gy (range, 37.5\u2013102) and 8 fractions (range, 5\u201314), respectively. The first, second, and third progression-free intervals (PFI) were 315 (n = 30), 185 (n = 11), and 218 days (n = 4), respectively. Overall survival (OS) was 504 days (n = 30). Adverse events such as alopecia (n = 7), white hair (n = 8), cataracts (n = 9), pigmentation (n = 5), keratitis (n = 3), and corneal ulceration (n = 1) were limited to grades 1 and 2. The medians of the first PFI for one course and two or more courses of re-RT were 298 and 331 days, respectively, indicating no significant differences between the groups. The OS after two or more courses of re-RT (758 days) was significantly longer than after one course of re-RT alone (414 days) (P = 0.048). However, the cases were not randomized and most of the tumor types were adenocarcinomas. \n\nConclusion: \nSince it is expected to prolong survival time with few life-threatening adverse events, the findings of the present study suggest that hypofractionated re-RT can be used in dogs with recurrent intranasal tumors initially treated with hypofractionated RT. Therefore, repeated hypofractionated re-RT may be a reasonable option for young dogs with a good initial response and recurrent intranasal tumors.<\/jats:p>","DOI":"10.5455\/ovj.2025.v15.i2.32","type":"journal-article","created":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T20:12:41Z","timestamp":1741551161000},"page":"1","source":"Crossref","is-referenced-by-count":0,"title":["&lt;b&gt;Clinical outcomes and prognostic factors of repeated conventional hypofractionated radiotherapy for recurrent intranasal tumors in dogs&lt;\/b&gt;"],"prefix":"10.5455","author":[{"given":"Hirona","family":"Ueno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Maruo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Yoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kayanuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Open Veterinary Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/100\/100-1730267797_TYP.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:18:11Z","timestamp":1791483491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/100\/100-1730267797.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5455\/ovj.2025.v15.i2.32","relation":{},"ISSN":["2226-4485"],"issn-type":[{"value":"2226-4485","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}