{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:30:58Z","timestamp":1794324658267,"version":"4.9.0"},"reference-count":0,"publisher":"ScopeMed","issue":"0","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":90,"URL":"https:\/\/www.openveterinaryjournal.com\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Vet J"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: \nAlzheimer's disease (AD) is characterized by the buildup and aggregation of misfolded proteins in the brain, including amyloid-\u03b2 (A\u03b2) and hyperphosphorylated tau. The hyperphosphorylation state of Tau protein plays an important role in the development of AD. Our previous studies developed and characterized the cynomolgus monkey as a spontaneous animal model of AD.\n\nAim: \nWe demonstrated the validity of the model through experimental investigations of the relationships between cognitive decline and the neuro-pathy of AD. There is, however, little information about the expression actvity of hyperphosphorylated tau related genes in various brain areas in the in cynomolgus monkey spontaneous AD model.\n\nMethods:  \nIn the present study, total RNA was extracted from archived cortex and hippocampus tissues from the brains of two groups of cynomolgus monkeys,  adult (10-12 years old, n=5) and aged (&gt; 20 years old, n=4). The expression of the tau-protein-associated genes GSK3\u03b2, CAPN1, and CDK5R1 was evaluated using RT-qPCR technique\n\nResults: \nThe expression of all three genes was increased up to five fold in the brain cortical area of the aged subjects compared to the adults\n\nConclusion: \nThe results add weight to the utility of cynomolgus macaques as a valid spontaneous model in translational preclinical research involving studies of the effect of aging on the formation of hyperphosphorylated tau protein, which causes AD-related lesions in the brain.<\/jats:p>","DOI":"10.5455\/ovj.2025.v15.i3.7","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T12:17:28Z","timestamp":1743509848000},"page":"1","source":"Crossref","is-referenced-by-count":0,"title":["&lt;b&gt;Expression profiles of the Tau-associated genes &lt;i&gt;GSk3\u03b2&lt;\/i&gt;, &lt;i&gt;CAPN1&lt;\/i&gt;, and &lt;i&gt;CDK5R1&lt;\/i&gt; in the brain cortex of aged female cynomolgus monkeys with cognitive impairment&lt;\/b&gt;"],"prefix":"10.5455","author":[{"given":"Huda","family":"Darusman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis","family":"Rosmanah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sela","family":"Mariya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uus","family":"Saepuloh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliana","family":"Yuliana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jann","family":"Hau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Open Veterinary Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/100\/100-1731377049_TYP.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:18:20Z","timestamp":1791483500000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejmanager.com\/mnstemps\/100\/100-1731377049.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5455\/ovj.2025.v15.i3.7","relation":{},"ISSN":["2226-4485"],"issn-type":[{"value":"2226-4485","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}