{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:30:59Z","timestamp":1794324659697,"version":"4.9.0"},"reference-count":0,"publisher":"ScopeMed","issue":"6","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":188,"URL":"https:\/\/www.openveterinaryjournal.com\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Vet J"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: \nIn therapeutic scenarios, the antiinflammatory medication dexamethasone is frequently administered. However, the consequences of prolonged use and dose residue may result in dexamethasone toxicity. Astaxanthin is a carotenoid antioxidant that may lessen the harmful effects of dexamethasone.\n\nAim: \nThis study aimed to investigate the efficacy of astaxanthin in a dexamethasone toxicity model in the kidney of albino rats based on hematological profiles and IL-6 and TNF-\u03b1 expression.\n\nMethods: \nThe study involved the random assignment of 25 albino rats into five treatment groups with five replications: (C-) placebo, (C+) intramuscular injection of 0.75 mg\/kg BW of dexamethasone, and (T1, T2, and T3) intramuscular injection of 0.75 mg\/kg BW of dexamethasone and oral administration of 2, 6, and 12 mg\/kg BW of astaxanthin, respectively. All experimental animals were administered therapy for 10 days. Hematological profiles were evaluated using a blood analyzer, whereas IL-6 and TNF-\u03b1 expression was evaluated using immunohistochemical staining.\n\nResults: \nBased on leukocyte, erythrocyte, hemoglobin, and hematocrit characteristics, groups T2 and T3 were generally found to be significantly different (p &lt; 0.05) from group C+ regarding the reduction of the effects of dexamethasone. In the meantime, group T3 showed a significant (p &lt; 0.05) decrease in TNF-\u03b1 and IL-6 expression compared with group C+.\n\nConclusion: \nThe administration of 12 mg\/kg BW of astaxanthin may be an antidote to dexamethasone toxicity in albino rats, according to the overall assessment of the hematological profile, IL-6, and TNF-\u03b1 cytokines in the kidney.<\/jats:p>","DOI":"10.5455\/ovj.2025.v15.i6.23","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T20:08:35Z","timestamp":1751918915000},"page":"2511","source":"Crossref","is-referenced-by-count":2,"title":["&lt;b&gt;Astaxanthin improves hematology, interleukin-6, and tumor necrosis factor-\u03b1 in the albino rats\u2019 kidney model of dexamethasone toxicity&lt;\/b&gt;"],"prefix":"10.5455","volume":"15","author":[{"given":"Faisal","family":"Fikri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auliyauna","family":"Miftahurrohmah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Pratama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danis","family":"Qosdina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gigih","family":"Sya\u2019ban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salipudin","family":"Maslamama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Purnama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Open Veterinary Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.bibliomed.org\/fulltextpdf.php?mno=240862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:18:39Z","timestamp":1791483519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.openveterinaryjournal.com\/?mno=240862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5455\/ovj.2025.v15.i6.23","relation":{},"ISSN":["2226-4485"],"issn-type":[{"value":"2226-4485","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}