{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:31:07Z","timestamp":1794324667499,"version":"4.9.0"},"reference-count":0,"publisher":"ScopeMed","issue":"2","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/www.openveterinaryjournal.com\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Vet. J."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: \nSpirulina platensis is a blue-green microalga known for its health benefits, including treating cardiovascular disease. However, research on the functional properties of S. platensis extracted via sonication remains limited.\n\nAim: \nTo investigate the efficacy of S. platensis hydromethanolic extract (SPE) on controlling blood pressure, renin\u2013angiotensin\u2013aldosterone system hormones, including renin, angiotensin-converting enzyme (ACE), and angiotensin II (Ang II), and pro-inflammatory cytokines in the spontaneously hypertensive rats (SHRs) model.\n\nMethods: \nTwenty-five male Wistar rats were divided into five groups (n = 5), and the 20 rats were administered deoxycorticosterone acetate-salt for 5 weeks to induce SHR and treated orally with SPE for 28 days. Blood pressure was evaluated three times: initial, middle, and final treatment. The rats were then sacrificed, and the blood serum was collected. The serum was then analyzed for renin, Ang II, ACE, tumor necrosis factor-\u03b1, and interleukin (IL)-6 using enzyme-linked immunosorbent assay. Malondialdehyde was determined based on a colorimetric assay.\n\nResults: \nOur results demonstrated that SPE could reduce hypertensive, inflammatory, and lipid peroxidation markers significantly (p &lt; 0.05).\n\nConclusion: \nOur finding suggested that SPE improves hypertension by maintaining inflammation and antioxidants. Spirulina platensis may be regarded as a potential nutraceutical supplement S. platensis may be regarded as a potential nutraceutical supplement from fishery product for managing hypertension and other diseases associated with inflammation disturbances.<\/jats:p>","DOI":"10.5455\/ovj.2026.v16.i2.24","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T12:03:12Z","timestamp":1772280192000},"page":"1038","source":"Crossref","is-referenced-by-count":0,"title":["&lt;b&gt;The protective effects of Spirulina platensis hydromethanolic extract against deoxycorticosterone acetate-salt-induced spontaneously hypertensive rats&lt;\/b&gt;"],"prefix":"10.5455","volume":"16","author":[{"given":"Putut","family":"Riyadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eko","family":"Susanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tri","family":"Agustini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apri","family":"Anggo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mochammad","family":"Atho\u2019illah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Open Veterinary Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.bibliomed.org\/fulltextpdf.php?mno=275103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:19:37Z","timestamp":1791483577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.openveterinaryjournal.com\/?mno=275103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5455\/ovj.2026.v16.i2.24","relation":{},"ISSN":["2226-4485"],"issn-type":[{"value":"2226-4485","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}