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Antibiotics (Basel). 9, 9."},{"key":"ref6","unstructured":"Al-Ghamdi, G.M. 2008. Most common diseases"},{"key":"ref7","unstructured":"impacting horse health in the major regions of"},{"key":"ref8","unstructured":"Saudi Arabia. Adv 7, 581\u2013583."},{"key":"ref9","unstructured":"Al-Qudari, A., Ghamdi, A. and Al-Jabr, O. 2015."},{"key":"ref10","unstructured":"Prevalence of gastrointestinal parasites in horses"},{"key":"ref11","unstructured":"in the Eastern province of Saudi Arabia King Saud"},{"key":"ref12","unstructured":"University. Basic Appl. Sci. 16, 37\u201347."},{"key":"ref13","unstructured":"Arbaga, A., Hassan, H., Kasem, M. and Kamr, A."},{"key":"ref14","unstructured":"2024. Ultrasonography as an accurate tool for the"},{"key":"ref15","unstructured":"diagnosis of equine sand colic with special reference"},{"key":"ref16","unstructured":"to hematological and biochemical alterations. Curr."},{"key":"ref17","unstructured":"Vet. Res. 6, 168\u2013176."},{"key":"ref18","unstructured":"Bertone, J.J., Traub-Dargatz, J.L., Wrigley, R.W.,"},{"key":"ref19","unstructured":"Bennett, D.G. and Williams, R.J. 1988. Diarrhea"},{"key":"ref20","unstructured":"associated with sand in the gastrointestinal tract. J."},{"key":"ref21","unstructured":"Am. Vet. Med. Assoc. 193, 1409\u20131412."},{"key":"ref22","unstructured":"Bither, H.D. and Sullivan, E.M. 1954. Sand colic."},{"key":"ref23","unstructured":"Cornell Vet. 44, 294\u2013298."},{"key":"ref24","unstructured":"Brosnahan, M.M. 2020. Eosinophils of the horse: part"},{"key":"ref25","unstructured":"II: eosinophils in clinical diseases. Eq. Vet. Edu. 32,"},{"key":"ref26","unstructured":"Entwisle, I.G., Byrne, D.P., Lester, G.D. and McConnell,"},{"key":"ref27","unstructured":"E.J. 2025. The radiographic area of large intestinal"},{"key":"ref28","unstructured":"sand accumulation in horses may determine its"},{"key":"ref29","unstructured":"clinical significance. Aust. Vet. J. 8 890\u2013893."},{"key":"ref30","unstructured":"Fehrmann-Cartes, K., Coronado AJ Hernandez.,"},{"key":"ref31","unstructured":"Allende. and Feijoo. 2019. Antiinflammatory"},{"key":"ref32","unstructured":"effects of aloe vera on intestinal inflammation"},{"key":"ref33","unstructured":"induced by soy meal in zebrafish. Fish Shellfish"},{"key":"ref34","unstructured":"Immunol. 95, 564\u2013573."},{"key":"ref35","unstructured":"Ferraro. 1973. Diagnosis and treatment of horse sand"},{"key":"ref36","unstructured":"colic. Vet. Med. Small Anim. Clinics 68, 736."},{"key":"ref37","unstructured":"Haasbroek, A., Willers, C., Glyn, M., Du Plessis, L."},{"key":"ref38","unstructured":"and Hamman, J. 2019. Intestinal drug absorption"},{"key":"ref39","unstructured":"enhancement by aloe vera gel and whole leaf extract: in vitro investigations into the mechanisms"},{"key":"ref40","unstructured":"of action. Pharmaceutics 11, 36."},{"key":"ref41","unstructured":"Hammock, P.D., Freeman, D.E. and Baker, G.J."},{"key":"ref42","unstructured":"1998. Failure of psyllium mucilloid to hasten the"},{"key":"ref43","unstructured":"evaluation of sand from the equine large intestine."},{"key":"ref44","unstructured":"Vet. Surg. 27, 547\u2013554."},{"key":"ref45","unstructured":"Hart, K.A., West, L., Mayer, J.R., House, A.M., Gold,"},{"key":"ref46","unstructured":"J.R. and Giguere, S. 2013. Management of sand"},{"key":"ref47","unstructured":"enteropathy in 62 horses. Equine. Vet. J. 45, 465\u2013"},{"key":"ref48","unstructured":"Hassel, D.M., Curley, T. and Hoaglund, E.L. 2020."},{"key":"ref49","unstructured":"Evaluation of fecal sand clearance in horses with"},{"key":"ref50","unstructured":"naturally acquired colonic sand accumulation with"},{"key":"ref51","unstructured":"a probiotic, prebiotic, and psyllium-containing"},{"key":"ref52","unstructured":"Product. J. Equine. Vet. Sci. 90, 102970."},{"key":"ref53","unstructured":"Hotwagner, K. and Iben, C. 2008. Sand from the"},{"key":"ref54","unstructured":"equine intestine with mineral oil, with and without"},{"key":"ref55","unstructured":"psyllium. J. Anim. Physiol. Anim. Nutr. (Berl). 92,"},{"key":"ref56","unstructured":"Husted, L., Andersen, M.S., Borggaard, O.K., Houe, H."},{"key":"ref57","unstructured":"and Olsen, S.N. 2005. Risk factors for fecal sand"},{"key":"ref58","unstructured":"excretion in Icelandic horses. Equine. Vet. J. 37,"},{"key":"ref59","unstructured":"Kaikkonen, R., Niinist\u00f6, K., Lindholm, T. and Raekallio,"},{"key":"ref60","unstructured":"M. 2016. Comparison of psyllium feeding at"},{"key":"ref61","unstructured":"home and nasogastric intubation of psyllium and"},{"key":"ref62","unstructured":"magnesium sulfate in the hospital as a treatment"},{"key":"ref63","unstructured":"for naturally occurring colonic sand (geosediment)"},{"key":"ref64","unstructured":"accumulations in horses: a retrospective study. Acta"},{"key":"ref65","unstructured":"Vet. Scand. 58, 73."},{"key":"ref66","unstructured":"Kilcoyne, I., Dechant, J.E., Spier, S.J., Spriet, M. and"},{"key":"ref67","unstructured":"Nieto, J.E. 2017. Clinical findings and management"},{"key":"ref68","unstructured":"of large colon sand accumulations in 153 horses."},{"key":"ref69","unstructured":"Vet. Surg. 46, 860\u2013867."},{"key":"ref70","unstructured":"Kim, M.W., Kang, J.H., Shin, E., Shim, K.S., Kim, M.J.,"},{"key":"ref71","unstructured":"Lee, C.K., Yoon, Y .S. and Oh, S.H. 2019. Processed"},{"key":"ref72","unstructured":"aloe vera gel attenuates NSAID-induced small"},{"key":"ref73","unstructured":"intestinal injury by enhancing mucin expression."},{"key":"ref74","unstructured":"Food Funct. 10, 6088\u20136097."},{"key":"ref75","unstructured":"Loschelder, J.A. and Gehlen, H. 2017. Sand colic in the"},{"key":"ref76","unstructured":"horse-review and case examples. Pferdeheilkunde"},{"key":"ref77","unstructured":"33, 591\u2013596."},{"key":"ref78","unstructured":"Maiuolo, J., Musolino, V ., Gliozzi, M., Carresi,"},{"key":"ref79","unstructured":"C., Scarano, F., Nucera, S., Scicchitano, M.,"},{"key":"ref80","unstructured":"Oppedisano, F., Bosco, F., Macri, R., Palma, E.,"},{"key":"ref81","unstructured":"Muscoli, C. and Mollace, V . 2022. 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Owner-"},{"key":"ref113","unstructured":"reported clinical signs and management-related"},{"key":"ref114","unstructured":"factors in intestinal sand accumulation in horses. J."},{"key":"ref115","unstructured":"Equine Vet. Sci. 80(10), 10\u201315."},{"key":"ref116","unstructured":"Niinisto, K.E., Ruohoniemi, M.O., Freccero, F."},{"key":"ref117","unstructured":"and Raekallio, M.R. 2018. Treatment of sand"},{"key":"ref118","unstructured":"accumulations in the large equine colon with"},{"key":"ref119","unstructured":"psyllium and magnesium sulfate. Vet. J. 238, 22\u201326."},{"key":"ref120","unstructured":"Panahi, Y ., North, R., Zamani, A. and Sahebkar, A."},{"key":"ref121","unstructured":"2020. Therapeutic effects of aloe vera and olive oil"},{"key":"ref122","unstructured":"combination cream versus topical betamethasone"},{"key":"ref123","unstructured":"for atopic dermatitis: a randomized double-blind"},{"key":"ref124","unstructured":"clinical trial. J. Pharmacopuncture. 23, 173\u2013178."},{"key":"ref125","unstructured":"Po, B.T., Campos-Krauer, J.M., Sullivan, K.E."},{"key":"ref126","unstructured":"and Warren D Vyas. 2023. Effect of psyllium husk supplementation on equine fecal nutrient"},{"key":"ref127","unstructured":"composition and in vitro fermentation. J. Equine"},{"key":"ref128","unstructured":"Vet. Sci. 124, 140."},{"key":"ref129","unstructured":"Rotting, A.K., Freeman, D.E., Constable, P.D., Moore,"},{"key":"ref130","unstructured":"R.M., Eurell, J.C., Wallig, M.A. and Hubert, J.D."},{"key":"ref131","unstructured":"2008. Effects of Strongylus vulgaris parasitism"},{"key":"ref132","unstructured":"on eosinophil distribution and accumulation in"},{"key":"ref133","unstructured":"equine large intestinal mucosa. Equine. Vet. J. 40,"},{"key":"ref134","unstructured":"Salim, R.H., Salloum, A.M., Alsalameh, S.A., Khazem,"},{"key":"ref135","unstructured":"M.R. and Hajeer, M.Y . 2024. Antimicrobial"},{"key":"ref136","unstructured":"properties of aloe vera ethanol extract as a denture"},{"key":"ref137","unstructured":"disinfectant: an in vitro study. Cureus 16, e59916."},{"key":"ref138","unstructured":"S\u00e1nchez, M., Gonz\u00e1lez-Burgos, E., Iglesias, I. and"},{"key":"ref139","unstructured":"G\u00f3mez-Serranillos, M.P. 2020. Pharmacological"},{"key":"ref140","unstructured":"update properties of aloe vera and its major active"},{"key":"ref141","unstructured":"constituents. Molecules 25(4.4), 2001."},{"key":"ref142","unstructured":"Shokraneh, M., Ghalamkari, G., Toghyani, M. and"},{"key":"ref143","unstructured":"Landy, N. 2016. Influence of drinking water"},{"key":"ref144","unstructured":"containing Aloe vera (Aloe barbadensis Miller)"},{"key":"ref145","unstructured":"gel on broiler growth performance, intestinal"},{"key":"ref146","unstructured":"microflora, and humoral immune responses. 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