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Clinical and biochemical"},{"key":"ref3","unstructured":"study of pregnancy-related toxemia in Iraqi ewes."},{"key":"ref4","unstructured":"Vet. World 16(6), 1186\u20131192; doi:10.14202\/"},{"key":"ref5","unstructured":"vetworld.2023.1186-1192"},{"key":"ref6","unstructured":"Belardinelli, C., Bogdanov, S., Celli, N., Ferioli, M.,"},{"key":"ref7","unstructured":"Fini, M., Galli, A. and Vannini, L. 2020. Molecular"},{"key":"ref8","unstructured":"and cellular mechanisms of the effects of propolis"},{"key":"ref9","unstructured":"on inflammation, oxidative stress, and glycemic"},{"key":"ref10","unstructured":"control in patients with chronic diseases. Nutr."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Metab. 17, 65; doi:10.1186\/s12986-020-00485-5","DOI":"10.1186\/s12986-020-00485-5"},{"key":"ref12","unstructured":"Berry, B.J., Trewin, A.J., Amitrano, A.M., Kim, M."},{"key":"ref13","unstructured":"and Wojtovich, A.P. 2018. The protonmotive"},{"key":"ref14","unstructured":"force: mitochondrial uncoupling and reactive"},{"key":"ref15","unstructured":"http:\/\/www.openveterinaryjournal.com"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"F . A. Lattef et al.  Open Veterinary Journal , (2026), V ol. 16(2): 1222-1229","DOI":"10.5455\/OVJ.2026.v16.i2.40"},{"key":"ref17","unstructured":"1228oxygen species. J. Mol. Biol. 430(21), 3873\u20133891;"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"doi:10.1016\/j.jmb.2018.03.025","DOI":"10.1016\/j.jmb.2018.03.025"},{"key":"ref19","unstructured":"Bouwman, R.A., Musters, R.J., Van Beek-harmsen,"},{"key":"ref20","unstructured":"B.J., De Lange, J.J. and Boer, C. 2019. During"},{"key":"ref21","unstructured":"cardiac surgery, reactive oxygen species precede"},{"key":"ref22","unstructured":"protein disulfide isomerase release from the"},{"key":"ref23","unstructured":"endoplasmic reticulum. PLos One. 14(6), 218724;"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"doi:10.1371\/journal.pone.0218724","DOI":"10.1371\/journal.pone.0218724"},{"key":"ref25","unstructured":"Brand, M.D. and Nicholls, D.G. 2011. Assessing"},{"key":"ref26","unstructured":"mitochondrial dysfunction in cells. Biochem. J."},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"435(2), 297\u2013312; doi: 10.1042\/BJ20110162","DOI":"10.1042\/BJ20110162"},{"key":"ref28","unstructured":"Brand, M.D., Orr, A.L., Perevoshchikova, I.V . and"},{"key":"ref29","unstructured":"Quinlan, C.L. 2019. The role of mitochondrial"},{"key":"ref30","unstructured":"function and cellular bioenergetics in aging and"},{"key":"ref31","unstructured":"disease. Br. J. Dermatol. 169(2), 1\u20138; doi:10.1111\/"},{"key":"ref32","unstructured":"Buettner, R., Nguyen, L.X.T., Morales, C., Chen, M.H.,"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Wu, X., Chen, L.S. and Rosen, S.T. 2021. Targeting","DOI":"10.1155\/2021\/6688708"},{"key":"ref34","unstructured":"the metabolic vulnerability of acute myeloid"},{"key":"ref35","unstructured":"leukemia blasts with a combination of venetoclax"},{"key":"ref36","unstructured":"and 8-chloro-adenosine. J. Hematol. Oncol. 14(1),"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"70; doi: 10.1186\/s13045-021-01076-4","DOI":"10.1186\/s13045-021-01076-4"},{"key":"ref38","unstructured":"Cal-Pereyra, L., Gonz\u00e1lez-Monta\u00f1a, J.R., Benech,"},{"key":"ref39","unstructured":"A., Acosta-Dibarrat, J., Mart\u00edn, A., Perini, S."},{"key":"ref40","unstructured":"and Rodr\u00edguez, P. 2015. Evaluation of three"},{"key":"ref41","unstructured":"therapeutic alternatives for the early treatment of"},{"key":"ref42","unstructured":"ovine pregnancy toxemia. Irish Vet. J. 68(1), 25;"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"doi:10.1186\/s13620-015-0053-2","DOI":"10.1186\/s13620-015-0053-2"},{"key":"ref44","unstructured":"Calvin-Pereira L Gonz., \u00e1lez-Monta\u00f1a, J.R., Benech"},{"key":"ref45","unstructured":"A Acosta., -Dibarrat, J., Mart\u00edn, A., Perini, S."},{"key":"ref46","unstructured":"and Rodr\u00edguez, P. 2015. Changes in some blood"},{"key":"ref47","unstructured":"indicators of pregnant ewes with toxemia treated"},{"key":"ref48","unstructured":"with propylene glycol or glycerol. J. Dairy Res."},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"82(4), 394\u2013399; doi:10.1017\/S0022029915000436","DOI":"10.1017\/S0022029915000436"},{"key":"ref50","unstructured":"Cedikova, M., Pitule, P., Kripnerova, M., Markova, M."},{"key":"ref51","unstructured":"and Kuncova, J. 2014. Effects of Czech propolis"},{"key":"ref52","unstructured":"on mitochondrial function in sperm. Evid. Based"},{"key":"ref53","unstructured":"Complement. Alternat. Med. 2014, 248768;"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"doi:10.1155\/2014\/248768","DOI":"10.1155\/2014\/248768"},{"key":"ref55","unstructured":"Fawaz, M.A., Ali, M.A. and Khalaphallah, R. 2025."},{"key":"ref56","unstructured":"Impacts of propolis and Spirulina platensis"},{"key":"ref57","unstructured":"supplementation on Japanese quail growth, nutrient"},{"key":"ref58","unstructured":"digestibility, and gut microbiota under heat stress."},{"key":"ref59","unstructured":"Sci. Rep. 15, 31688; doi:10.1038\/s41598-025-"},{"key":"ref60","unstructured":"Franco, L.V .R., Su, C.H. and Tzagoloff, A. 2020."},{"key":"ref61","unstructured":"Modular assembly of ATP synthase and cytochrome"},{"key":"ref62","unstructured":"oxidase in yeast mitochondria. Biol. Chem."},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"401(6-7), 835\u2013853; doi:10.1515\/hsz-2020-0112","DOI":"10.1515\/hsz-2020-0112"},{"key":"ref64","unstructured":"Habtemariam. and S. 2020. Exploring the prospective"},{"key":"ref65","unstructured":"role of propolis in modifying aging hallmarks."},{"key":"ref66","unstructured":"Biomed. Pharmacother. 128, 110262; doi:10.1016\/j."},{"key":"ref67","unstructured":"biopha.2020.110262"},{"key":"ref68","unstructured":"Kandiel, M.M.M., El-Khaiat, H.M. and Karima, M.M."},{"key":"ref69","unstructured":"2019. Changes in some hematobiochemical and"},{"key":"ref70","unstructured":"hormonal profiles of Barki sheep with various"},{"key":"ref71","unstructured":"reproductive statuses. Small. Ruminant. Res."},{"key":"ref72","unstructured":"136(3), 87\u201395; doi:10.1007\/s11250-011-9966-2Koopman, W.J.H., Nijtmans, L.G.J., Dieteren,"},{"key":"ref73","unstructured":"C.E.J., Roestenberg, P., Valsecchi, F., Smeitink,"},{"key":"ref74","unstructured":"J.A.M. and Willems, P.H.G.M. 2012. Mammalian"},{"key":"ref75","unstructured":"mitochondrial complex I: biogenesis, regulation,"},{"key":"ref76","unstructured":"and reactive oxygen species generation. Antioxid."},{"key":"ref77","unstructured":"Redox Signal. 12(12), 1431\u20131470; doi:10.1089\/"},{"key":"ref78","unstructured":"ars.2009.2743"},{"key":"ref79","unstructured":"Kurek-G\u00f3recka, A., Walczy\u0144ska-Dragon, K., Felitti,"},{"key":"ref80","unstructured":"R., Baron, S. and Olczyk, P. 2022. Propolis and diet"},{"key":"ref81","unstructured":"rich in polyphenols as cariostatic agents reducing"},{"key":"ref82","unstructured":"accumulation of dental plaque. Molecules 27(1),"},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"271; doi: 10.3390\/molecules27010271","DOI":"10.3390\/molecules27010271"},{"key":"ref84","unstructured":"Ley-Ngardigal, S.A., Rodr\u00edguez-Nuevo A Sch.,"},{"key":"ref85","unstructured":"\u00e4ffner I Adrover., Hakimi, A., Brunet, M. and"},{"key":"ref86","unstructured":"Mitter, A. 2022. Monitoring ATP levels in living"},{"key":"ref87","unstructured":"cells: where do we stand?. FEBS J. 289(2),"},{"key":"ref88","doi-asserted-by":"crossref","unstructured":"397\u2013426; doi:10.1111\/febs.16169","DOI":"10.1111\/febs.16169"},{"key":"ref89","unstructured":"Liu, M., Dai, Y ., Yao, X., Li, Y ., Luo, Q., Xia, Y ."},{"key":"ref90","unstructured":"and Chen, Z. 2022. Rosmarinic acid inhibits"},{"key":"ref91","unstructured":"mitochondrial damage by alleviating the unfolded"},{"key":"ref92","unstructured":"protein response. Front. Pharmacol. 13, 859978;"},{"key":"ref93","doi-asserted-by":"crossref","unstructured":"doi:10.3389\/fphar.2022.859978","DOI":"10.3389\/fphar.2022.859978"},{"key":"ref94","unstructured":"Naimi, M., Vlavcheski, F., Shamshoum, H. and Tsiani,"},{"key":"ref95","unstructured":"E. 2017. Rosemary extract as a potential anti-"},{"key":"ref96","unstructured":"hyperglycemic agent: current evidence and future"},{"key":"ref97","unstructured":"perspectives. Nutrients 9(9), 968; doi:10.3390\/"},{"key":"ref98","unstructured":"Nieto-Bona, A., Garc\u00eda, V ., Fern\u00e1ndez-Garc\u00eda, A.,"},{"key":"ref99","unstructured":"Olmo R Aguirre., Gonz, L., \u00e1lez-Param\u00e1s AM"},{"key":"ref100","unstructured":"Santos. and -Buelga, C. 2020. Antioxidant and anti-"},{"key":"ref101","unstructured":"inflammatory properties of a flavonoid-rich extract"},{"key":"ref102","unstructured":"from R. officinalis L. leaves. Antioxidants 9(11),"},{"key":"ref103","doi-asserted-by":"crossref","unstructured":"1073; doi:10.3390\/antiox9111073","DOI":"10.3390\/antiox9111073"},{"key":"ref104","unstructured":"Paradies, G., Paradies, V ., Ruggiero, F.M. and"},{"key":"ref105","unstructured":"Petrosillo, G. 2014. Oxidative stress, cardiolipin,"},{"key":"ref106","unstructured":"and mitochondrial dysfunction in NAFLD. World. J."},{"key":"ref107","unstructured":"Gastroenterol. 20(39), 14205\u201314218; doi:10.3748\/"},{"key":"ref108","unstructured":"wjg.v20.i39.14205"},{"key":"ref109","unstructured":"Patlevi\u010d, P., Va\u0161kov\u00e1, J., \u0160vorc Jr, P., Va\u0161ko, L. and"},{"key":"ref110","unstructured":"\u0160vorc, P. 2016. Reactive oxygen species and"},{"key":"ref111","unstructured":"antioxidant defense in human gastrointestinal"},{"key":"ref112","unstructured":"diseases. Integrative Med. Res. 5(4), 250\u2013258; doi:"},{"key":"ref113","doi-asserted-by":"crossref","unstructured":"10.1016\/j.imr.2016.07.004","DOI":"10.1016\/j.imr.2016.07.004"},{"key":"ref114","unstructured":"Pasciu, V ., Nieddu, M., Sotgiu, F.D., Baralla, E. and"},{"key":"ref115","unstructured":"Berlinguer, F. 2023. An overview on assay methods"},{"key":"ref116","unstructured":"to quantify ROS and enzymatic antioxidants in"},{"key":"ref117","unstructured":"erythrocytes and spermatozoa of small domestic"},{"key":"ref118","unstructured":"ruminants. Animals 13(14), 2300; doi: 10.3390\/"},{"key":"ref119","unstructured":"ani13142300"},{"key":"ref120","unstructured":"Pasciu, V ., Nieddu, M., Sotgiu, F.D., Baralla, E. and"},{"key":"ref121","unstructured":"Berlinguer, F. 2023. An overview of assay methods"},{"key":"ref122","unstructured":"to quantify ROS and enzymatic antioxidants"},{"key":"ref123","unstructured":"in small domestic ruminant erythrocytes and"},{"key":"ref124","unstructured":"spermatozoa. Animals (Basel). 13(14), 2300;"},{"key":"ref125","doi-asserted-by":"crossref","unstructured":"doi:10.3390\/ani13142300","DOI":"10.3390\/ani13142300"},{"key":"ref126","unstructured":"Shedeed, H.A., Farrag, B., Elwakeel, E.A., Abd El-"},{"key":"ref127","unstructured":"Hamid, I.S. and El-Rayes, M.A.H. 2019. Propolis"},{"key":"ref128","unstructured":"supplementation improved productivity, oxidative"},{"key":"ref129","unstructured":"http:\/\/www.openveterinaryjournal.com"},{"key":"ref130","doi-asserted-by":"crossref","unstructured":"F . A. Lattef et al. Open Veterinary Journal , (2026), V ol. 16(2): 1222-1229","DOI":"10.5455\/OVJ.2026.v16.i2.40"},{"key":"ref131","unstructured":"1229status, and immune response of Barki ewes and"},{"key":"ref132","unstructured":"lambs. Vet. World 12(6), 834; doi: 10.14202\/"},{"key":"ref133","unstructured":"vetworld.2019.834-843"},{"key":"ref134","unstructured":"Simitzis, P.E., Deligeorgis, S.G., Bizelis, J.A.,"},{"key":"ref135","unstructured":"Dardamani, A., Theodosiou, I. and Fegeros, K."},{"key":"ref136","unstructured":"2008. Effect of dietary oregano oil supplementation"},{"key":"ref137","unstructured":"on lamb meat characteristics. Meat. Sci. 79(2),"},{"key":"ref138","doi-asserted-by":"crossref","unstructured":"217\u2013223; doi:10.1016\/j.meatsci.2007.09.005","DOI":"10.1016\/j.meatsci.2007.09.005"},{"key":"ref139","unstructured":"Spinazzi, M., Casarin, A., Pertegato, V ., Salviati, L."},{"key":"ref140","unstructured":"and Angelini, C. 2012. Assessment of enzymatic"},{"key":"ref141","unstructured":"activities of mitochondrial respiratory chains in"},{"key":"ref142","unstructured":"tissues and cultured cells. Nature Protocols 7(6),"},{"key":"ref143","doi-asserted-by":"crossref","unstructured":"1235\u20131246; doi:10.1038\/nprot.2012.058","DOI":"10.1038\/nprot.2012.058"},{"key":"ref144","unstructured":"Talafha, A.Q. and Ababneh, M.M. 2011. Awassi sheep"},{"key":"ref145","unstructured":"reproduction and milk production. Trop. Anim."},{"key":"ref146","unstructured":"Health Prod. 43(7), 1319\u20131326; doi: 10.1007\/"},{"key":"ref147","unstructured":"s11250-011-9858-5"},{"key":"ref148","unstructured":"Tvrd\u00e1, E., \u00c1rvay, J., \u010eura\u010dka, M. and Ka\u010d\u00e1niov\u00e1,"},{"key":"ref149","unstructured":"M. 2023. Mitochondria-stimulating and"},{"key":"ref150","doi-asserted-by":"crossref","unstructured":"antioxidant effects of slovak propolis on bovine spermatozoa. Oxygen 3(2), 179\u2013189; doi:10.3390\/","DOI":"10.3390\/oxygen3020013"},{"key":"ref151","unstructured":"oxygen3020013"},{"key":"ref152","unstructured":"Wang, T., Takikawa, Y . and Tabuchi, T. 2013. Rosemary"},{"key":"ref153","unstructured":"(Rosmarinus officinalis L.) extract regulates glucose"},{"key":"ref154","unstructured":"and lipid metabolism by activating the AMPK"},{"key":"ref155","unstructured":"and PPAR pathways in HepG2 cells. J. Agricult."},{"key":"ref156","unstructured":"Food Chem. 61(11), 2803\u20132810; doi:10.1016\/j."},{"key":"ref157","doi-asserted-by":"crossref","unstructured":"jafc.2012.08.010","DOI":"10.1088\/1475-7516\/2012\/08\/010"},{"key":"ref158","unstructured":"Yu, C., Luo, Y . and Shen, C. 2024. Effects of microbe-"},{"key":"ref159","unstructured":"derived antioxidants on growth performance,"},{"key":"ref160","unstructured":"hepatic oxidative stress, mitochondrial function"},{"key":"ref161","unstructured":"and cell apoptosis in weaning piglets. Nat. Biol."},{"key":"ref162","unstructured":"Chem. Biol. J. Anim. Sci. 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