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Options","DOI":"10.1155\/2012\/851941"},{"key":"ref3","unstructured":"for integrated strategies for the control of avian"},{"key":"ref4","unstructured":"coccidiosis. Int. J. Agri. Biol. 14(6), 1014\u20131020."},{"key":"ref5","unstructured":"Abdelnour, S.A., Abd El-hack, M.E., Khafaga, A.F.,"},{"key":"ref6","unstructured":"Arif, M., Taha, A.E. and Noreldin, A.E. 2020."},{"key":"ref7","unstructured":"Stress biomarkers and proteomics alteration to"},{"key":"ref8","unstructured":"thermal stress in ruminants: a review. J. Thermal."},{"key":"ref9","unstructured":"Biol. 79, 120\u2013134."},{"key":"ref10","unstructured":"Abuelo, A., Hern\u00e1ndez, J., Benedito, J.L. and Castillo,"},{"key":"ref11","unstructured":"C. 2019. Redox Biology in Transition Periods of"},{"key":"ref12","unstructured":"Dairy Cattle: role in the Health of Periparturient"},{"key":"ref13","unstructured":"and Neonatal Animals. Antioxidants 8(1), 20;"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"doi:10.3390\/antiox8010020","DOI":"10.3390\/antiox8010020"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Aebi, H. 1984. Catalase in vitro. Methods. Enzymology.","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"ref16","unstructured":"105, 121\u2013126."},{"key":"ref17","unstructured":"http:\/\/www.openveterinaryjournal.com"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"M. A. A. Al-Qaysi et al. Open Veterinary Journal , (2026), V ol. 16(2): 1272-1280","DOI":"10.5455\/OVJ.2026.v16.i2.44"},{"key":"ref19","unstructured":"1279Afzal, A., Hussain, T. and Hameed, A. 2018. Moringa"},{"key":"ref20","unstructured":"oleifera supplementation improves antioxidant"},{"key":"ref21","unstructured":"status and biochemical indices in beetles by"},{"key":"ref22","unstructured":"attenuating early pregnancy stress. Front. Nutr. 8,"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"700957; doi: 10.3389\/fnut.2021.700957","DOI":"10.3389\/fnut.2021.700957"},{"key":"ref24","unstructured":"Al-Dawood. and A. 2017. Heat stress management in"},{"key":"ref25","unstructured":"small ruminants: a review. Ann. Anim. Sci. 17(1),"},{"key":"ref26","unstructured":"Alhussien, M.N. and Dang, A.K. 2018. Milk somatic"},{"key":"ref27","unstructured":"cells, factors influencing their release, future"},{"key":"ref28","unstructured":"prospects, and practical utility in dairy animals: an"},{"key":"ref29","unstructured":"overview. Vet. World. 11(5), 562\u2013577."},{"key":"ref30","unstructured":"Anand, P., Kunnumakkara, A.B., Newman, R.A. and"},{"key":"ref31","unstructured":"Aggarwal, B.B. 2007. Curcumin bioavailability:"},{"key":"ref32","unstructured":"problems and promises. Mol. Pharmaceutics 4(6),"},{"key":"ref33","unstructured":"Arulselvan, P., Fard, M.T., Tan, W.S., Gothai, S.,"},{"key":"ref34","unstructured":"Fakurazi, S., Norhaizan, M.E. and Kumar, S.S."},{"key":"ref35","unstructured":"2016. Role of antioxidants and natural products"},{"key":"ref36","unstructured":"in the treatment of inflammation. Oxidative Med."},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Cellular Longevity 2016, 5276130.","DOI":"10.1155\/2016\/4018417"},{"key":"ref38","unstructured":"Ashrafizadeh Z Ahmadi., Mohammadinejad T"},{"key":"ref39","unstructured":"Farkhondeh. and Samarghandian. 2020. Curcumin"},{"key":"ref40","unstructured":"activates the Nrf2 pathway and protects cells against"},{"key":"ref41","unstructured":"oxidative injury. Curr. Mol. Med. 20(2), 116\u2013133."},{"key":"ref42","unstructured":"Bagath, M., Krishnan, G., Devaraj, C., Rashamol, V .P.,"},{"key":"ref43","unstructured":"Pragna, P., Lees, A.M. and Sejian, V . 2019. Impact"},{"key":"ref44","unstructured":"of heat stress on the immune system in dairy cattle:"},{"key":"ref45","unstructured":"a review. Res. Vet. Sci. 126, 94\u2013102."},{"key":"ref46","unstructured":"Bernabucci. and U. 2019. Climate change: impact on"},{"key":"ref47","unstructured":"livestock and how we can adapt to it. Anim. Front."},{"key":"ref48","unstructured":"I., Najar, T., Ghram, A., Dabbebi, H., Ben Mrad, M."},{"key":"ref49","unstructured":"and Abdrabbah, M. 2014. Reactive oxygen species,"},{"key":"ref50","unstructured":"heat stress and oxidative-induced mitochondrial"},{"key":"ref51","unstructured":"damage. A review. Int. J. Hyperthermia 30(7), 513\u2013"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"523; doi:10.3109\/02656736.2014.971446","DOI":"10.3109\/02656736.2014.971446"},{"key":"ref53","unstructured":"Calabrese, V ., Cornelius, C., Dinkova-Kostova, A.T.,"},{"key":"ref54","unstructured":"Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea,"},{"key":"ref55","unstructured":"S., Rizzarelli, E. and Calabrese, E.J. 2020. Cellular"},{"key":"ref56","unstructured":"stress responses, hormetic phytochemicals, and"},{"key":"ref57","unstructured":"vitagenes in aging and longevity. Biochimica. Et."},{"key":"ref58","unstructured":"Biophysica. Acta. 1822(5), 753\u2013783; doi:10.1016\/j."},{"key":"ref59","doi-asserted-by":"crossref","unstructured":"bbadis.2011.11.002","DOI":"10.1088\/1475-7516\/2011\/11\/002"},{"key":"ref60","unstructured":"Chauhan, S.S., Celi, P., Leury, B.J. and Dunshea,"},{"key":"ref61","unstructured":"F.R. 2021. High dietary selenium and vitamin E"},{"key":"ref62","unstructured":"supplementation reduces the effects of heat load on"},{"key":"ref63","unstructured":"oxidative status and acid-base balance in sheep. J."},{"key":"ref64","unstructured":"Anim. Sci. 93(7), 3342\u20133356."},{"key":"ref65","unstructured":"Dahl, G.E., Tao, S. and Laporta, J. 2020. Heat stress"},{"key":"ref66","unstructured":"impacts the immune status of cows across the life"},{"key":"ref67","unstructured":"cycle. Front. Vet. Sci. 7, 116."},{"key":"ref68","unstructured":"Das, R., Sailo, L., Verma, N., Bharti, P., Saikia, J.,"},{"key":"ref69","unstructured":"Imtiwati. and Kumar, R. 2020. Impact of heat stress"},{"key":"ref70","unstructured":"on the health and performance of dairy animals: a"},{"key":"ref71","unstructured":"review. Vet. World. 9(3), 260\u2013268."},{"key":"ref72","unstructured":"Dehzad, M.J., Ghalandari, H., Nouri, M. and Askarpour,"},{"key":"ref73","unstructured":"M. 2023. Antioxidant and anti-inflammatory effects of curcumin\/turmeric supplementation in adults:"},{"key":"ref74","unstructured":"a GRADE-assessed systematic review and dose-"},{"key":"ref75","unstructured":"response meta-analysis of randomized controlled"},{"key":"ref76","unstructured":"trials. Cytokine 164, 156144."},{"key":"ref77","unstructured":"Hamzaoui, S., Salama, A.A.K., Albanell, E., Such, X."},{"key":"ref78","unstructured":"and Caja, G. 2013. Physiological responses and"},{"key":"ref79","unstructured":"lactational performances of late-lactation dairy"},{"key":"ref80","unstructured":"goats under heat stress conditions. J. Dairy Sci."},{"key":"ref81","unstructured":"96(10), 6355\u20136365."},{"key":"ref82","unstructured":"He, Y ., Yue, Y ., Zheng, X., Zhang, K., Chen, S. and"},{"key":"ref83","unstructured":"Du, Z. 2023. Curcumin, inflammation, and chronic"},{"key":"ref84","unstructured":"diseases: how are they linked?. Molecules 20(5),"},{"key":"ref85","unstructured":"Hewlings, S. and Kalman, D. 2017. Curcumin: a review"},{"key":"ref86","doi-asserted-by":"crossref","unstructured":"of its effects on human health. Foods 6(10), 92.","DOI":"10.3390\/foods6100092"},{"key":"ref87","unstructured":"Hu, P., Li, K., Peng, X.X., Kan, Y ., Yao, T.J., Wang,"},{"key":"ref88","unstructured":"Z.Y . and Cai, D. 2023. Curcumin derived from"},{"key":"ref89","unstructured":"medicinal homologous foods: its main signal in"},{"key":"ref90","unstructured":"oxidative stress, inflammation, and apoptosis"},{"key":"ref91","unstructured":"immunoregulation. Front. Immunol. 14, 1233652."},{"key":"ref92","unstructured":"Hussen, J., Schuberth, H.J. and Rahman, M.M."},{"key":"ref93","unstructured":"2020. Innate and adaptive immune responses of"},{"key":"ref94","unstructured":"ruminants to Mycoplasma bovis infection: current"},{"key":"ref95","unstructured":"understanding and questions remaining. Vet."},{"key":"ref96","unstructured":"Immunol. Immunopathology. 228, 110108."},{"key":"ref97","doi-asserted-by":"crossref","unstructured":"Jee, H. 2016. Size-dependent classification of heat","DOI":"10.12965\/jer.1632642.321"},{"key":"ref98","unstructured":"shock proteins: a mini-review. J. Exercise. Rehabil."},{"key":"ref99","unstructured":"12(4), 255\u2013259."},{"key":"ref100","unstructured":"Kholif, A.E., Gouda, G.A. and Hamdon, H.A. 2021."},{"key":"ref101","unstructured":"Dietary Moringa oleifera alters periparturient"},{"key":"ref102","unstructured":"plasma and milk biochemical indicators and"},{"key":"ref103","unstructured":"promotes goat productivity. Front. Vet. Sci. 8,"},{"key":"ref104","unstructured":"Koch, F., Lamp, O., Eslamizad, M., Weitzel, J. and"},{"key":"ref105","unstructured":"Kuhla, B. 2019. Metabolic response to heat stress"},{"key":"ref106","unstructured":"in late-pregnant and early lactation dairy cows:"},{"key":"ref107","unstructured":"implications to liver-muscle crosstalk. PLos One"},{"key":"ref108","unstructured":"11(8), 215372."},{"key":"ref109","unstructured":"Kregel, K.C. 2002. Heat shock proteins: modifying"},{"key":"ref110","unstructured":"factors in physiological stress responses and"},{"key":"ref111","unstructured":"acquired thermotolerance. J. Appl. Physiol. 92(5),"},{"key":"ref112","unstructured":"Lacetera. and N. 2019. Impact of climate change on the"},{"key":"ref113","unstructured":"health and welfare of animals. Anim. Front. 9(1),"},{"key":"ref114","unstructured":"Leone, A., Spada, A., Battezzati, A., Schiraldi, A.,"},{"key":"ref115","unstructured":"Aristil, J. and Bertoli, S. 2020. Cultivation,"},{"key":"ref116","unstructured":"genetic, ethnopharmacology, phytochemistry"},{"key":"ref117","unstructured":"and pharmacology of Moringa oleifera leaves: an"},{"key":"ref118","unstructured":"overview. Plant Mol. Biol. Int. J. Mol. Sci. 16(6),"},{"key":"ref119","unstructured":"12791\u201312835."},{"key":"ref120","unstructured":"Liu, G., Zheng, J., Wu, X., Xu, X., Jing, J. and Zhao,"},{"key":"ref121","unstructured":"G. 2022. Mitochondrial Uncoupling Proteins and"},{"key":"ref122","unstructured":"Their Physiological Roles. Comprehensive Physiol."},{"key":"ref123","unstructured":"12(2), 3303\u20133325; doi:10.1002\/cphy.c210082"},{"key":"ref124","unstructured":"Marklund, S. and Marklund, G. 1974. Involvement of the"},{"key":"ref125","unstructured":"superoxide anion radical in pyrogallol autoxidation"},{"key":"ref126","unstructured":"http:\/\/www.openveterinaryjournal.com"},{"key":"ref127","doi-asserted-by":"crossref","unstructured":"M. A. A. Al-Qaysi et al. Open Veterinary Journal , (2026), V ol. 16(2): 1272-1280","DOI":"10.5455\/OVJ.2026.v16.i2.44"},{"key":"ref128","unstructured":"1280and a convenient superoxide dismutase assay. Eur."},{"key":"ref129","unstructured":"J. Biochem. 47(3), 469\u2013474."},{"key":"ref130","unstructured":"Min, L., Zheng, N., Zhao, S., Cheng, J., Yang, Y .,"},{"key":"ref131","unstructured":"Zhang, Y ., Yang, H. and Wang, J. 2019. Long-term"},{"key":"ref132","unstructured":"heat stress induces the inflammatory response in"},{"key":"ref133","unstructured":"dairy cows revealed by plasma proteome analysis."},{"key":"ref134","unstructured":"Biochem. Biophysical Res. Commun. 471(2), 296\u2013"},{"key":"ref135","unstructured":"Nrc. 2007. Nutrient Requirements of Small Ruminants:"},{"key":"ref136","unstructured":"sheep, Goats, Cervids, and Camelids of the New"},{"key":"ref137","unstructured":"World Washington, DC: The National Academies"},{"key":"ref138","unstructured":"Press. Washington, DC: The National Academies"},{"key":"ref139","unstructured":"Omodanisi, E.I., Aboua, Y .G. and Oguntibeju, O.O."},{"key":"ref140","unstructured":"2017. Assessment of the antihyperglycemic, anti-"},{"key":"ref141","unstructured":"inflammatory, and antioxidant activities of the"},{"key":"ref142","unstructured":"methanol extract of M. oleifera in male Wistar rats"},{"key":"ref143","unstructured":"with diabetes-induced nephrotoxicity. Molecules"},{"key":"ref144","unstructured":"22(4), 439."},{"key":"ref145","unstructured":"Paglia, D.E. and Valentine, W.N. 1967. Quantitative"},{"key":"ref146","unstructured":"and qualitative characterization of erythrocyte"},{"key":"ref147","unstructured":"glutathione peroxidase. J. Lab. Clin. Med. 70(1),"},{"key":"ref148","unstructured":"Pareek, A., Pant, M., Gupta, M.M., Kashania, P., Ratan,"},{"key":"ref149","unstructured":"Y ., Jain, V . and Chuturgoon, A.A. 2023. Moringa"},{"key":"ref150","unstructured":"oleifera: an updated comprehensive review of"},{"key":"ref151","unstructured":"its pharmacological activities, ethnomedicinal,"},{"key":"ref152","unstructured":"phytopharmaceutical formulation, and clinical,"},{"key":"ref153","unstructured":"phytochemical, and toxicological aspects. Int. J."},{"key":"ref154","unstructured":"Mol. Sci. 24(3), 2098."},{"key":"ref155","unstructured":"Paul, S., Ghosh, S., Mandal, S., Sau, S. and Pal, M."},{"key":"ref156","unstructured":"2021. NF-\u03baB and MAPK signaling pathways"},{"key":"ref157","unstructured":"mediate the immunomodulatory effects of Moringa"},{"key":"ref158","unstructured":"oleifera leaf extract. Int. Immunopharmacology"},{"key":"ref159","unstructured":"100, 108143."},{"key":"ref160","unstructured":"Peterson, C.T., Vaughn, A.R., Sharma, V ., Chopra, D.,"},{"key":"ref161","unstructured":"Mills, P.J., Peterson, S.N. and Sivamani, R.K. 2019."},{"key":"ref162","unstructured":"Effects of dietary supplementation with turmeric"},{"key":"ref163","unstructured":"and curcumin on human gut microbiota: a double-"},{"key":"ref164","unstructured":"blind, randomized, placebo-controlled pilot study."},{"key":"ref165","unstructured":"J. Evidence-Based. Integr. Med. 23(1), 1\u20138."},{"key":"ref166","unstructured":"Prasad, S., Tyagi, A.K. and Aggarwal, B.B. 2014. Recent"},{"key":"ref167","unstructured":"developments in curcumin delivery, bioavailability,"},{"key":"ref168","unstructured":"absorption, and metabolism: the golden pigment"},{"key":"ref169","unstructured":"from golden spice. Cancer Res. Treat. 46(1), 2\u201318."},{"key":"ref170","unstructured":"Renaudeau, D., Collin, A., Yahav, S., De Basilio, V .,"},{"key":"ref171","unstructured":"Gourdine, J.L. and Collier, R.J. 2012. Adaptation to"},{"key":"ref172","unstructured":"hot climate and strategies to alleviate heat stress in"},{"key":"ref173","unstructured":"livestock production. Animal 6(5), 707\u2013728."},{"key":"ref174","unstructured":"Rout, P.K., Kaushik, R. and Ramachandran, N. 2022."},{"key":"ref175","unstructured":"Differential expression and regulation of the"},{"key":"ref176","unstructured":"HSP70 gene during the growth phase in ruminants"},{"key":"ref177","unstructured":"in response to heat stress. Scientific Rep. 12, 18468.Saeed, M., Babazadeh, D., Naveed, M., Arain, M.A.,"},{"key":"ref178","unstructured":"Hassan, F.U. and Chao, S. 2019. The importance"},{"key":"ref179","unstructured":"of phytogenic feed additives in animal nutrition"},{"key":"ref180","unstructured":"should be reconsidered. Anim. Feed Sci. Technol."},{"key":"ref181","unstructured":"249, 54\u201367."},{"key":"ref182","unstructured":"Sejian, V ., Bhatta, R., Gaughan, J.B., Dunshea, F.R. and"},{"key":"ref183","unstructured":"Lacetera, N. 2018. Review: adaptation of animals"},{"key":"ref184","unstructured":"to heat stress. Animal 12(s2), s431\u2013s444."},{"key":"ref185","unstructured":"Singleton, V .L., Orthofer, R. and Lamuela-Ravent\u00f3s,"},{"key":"ref186","unstructured":"R.M. 1999. Analysis of total phenols and other"},{"key":"ref187","unstructured":"oxidation substrates and antioxidants with Folin-"},{"key":"ref188","unstructured":"Ciocalteu reagent. Methods. Enzymology. 299,"},{"key":"ref189","unstructured":"Sophia, I., Sejian, V ., Bagath, M. and Bhatta, R."},{"key":"ref190","unstructured":"2016. Impact of heat stress on livestock immune"},{"key":"ref191","unstructured":"responses: a review. Pertanika. J. Trop. Agricult."},{"key":"ref192","unstructured":"Sci. 39(4), 459\u2013482."},{"key":"ref193","unstructured":"Stohs, S.J. and Hartman, M.J. 2015. Safety and efficacy"},{"key":"ref194","unstructured":"of Moringa oleifera. Phytotherapy Res. 29(6), 796\u2013"},{"key":"ref195","unstructured":"Surai, P.F., Kochish, I.I., Fisinin, V .I. and Kidd, M.T."},{"key":"ref196","unstructured":"2019. Antioxidant defense systems and oxidative"},{"key":"ref197","unstructured":"stress in poultry biology: an update. Antioxidants"},{"key":"ref198","unstructured":"Tiloke, C., Anand, K., Gengan, R.M. and"},{"key":"ref199","unstructured":"Chuturgoon, A.A. 2018. Moringa oleifera and"},{"key":"ref200","unstructured":"its phytonanoparticles: potential antiproliferative"},{"key":"ref201","unstructured":"agents against cancer. Biomed. Pharmacotherapy."},{"key":"ref202","unstructured":"108, 457\u2013466."},{"key":"ref203","unstructured":"Vahedian-Azimi, A., Abbasifard, M., Rahimi-Bashar,"},{"key":"ref204","unstructured":"F., Guest, P.C., Majeed, M., Mohammadi, A.,"},{"key":"ref205","unstructured":"Banach, M., Jamialahmadi, T. and Sahebkar, A."},{"key":"ref206","unstructured":"2022. Effectiveness of curcumin on outcomes of"},{"key":"ref207","unstructured":"hospitalized COVID-19 patients: a systematic"},{"key":"ref208","unstructured":"review of clinical trials. Nutrients 14(2), 256;"},{"key":"ref209","unstructured":"doi:10.1016\/j.nutrients.2014.09.010"},{"key":"ref210","unstructured":"Vergara-Jimenez, M., Almatrafi, M.M. and Fernandez,"},{"key":"ref211","unstructured":"M.L. 2017. Bioactive components in M. oleifera"},{"key":"ref212","unstructured":"leaves protect against chronic disease. 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