{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:31:07Z","timestamp":1794324667831,"version":"4.9.0"},"reference-count":0,"publisher":"ScopeMed","issue":"3","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":90,"URL":"https:\/\/www.openveterinaryjournal.com\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Vet. J."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: \nMale infertility is closely linked to testicular damage caused by environmental chemicals. Carbon tetrachloride (CCl\u2084), widely used in manufacturing chlorinated chemicals, is highly toxic to the liver, testes, and other organs. Its testicular toxicity involves oxidative stress, apoptosis, and hyperlipidemia. Plant-derived proteins such as soybeans, with phytoestrogenic properties, have gained attention for their potential health benefits. \n\nAim: \nThis study investigated the protective effect of soybean on CCl\u2084-induced testicular damage. \n\nMethods: \nTwenty-eight male albino rats were divided into four groups: control, CCl\u2084-treated (1.0 ml\/kg intraperitoneally, thrice weekly for three weeks), CCl\u2084-treated plus 10% soybean diet, and CCl\u2084-treated plus 30% soybean diet (as a schematic cartoon in Figure 1). After seven weeks, serum lipoproteins, testicular malondialdehyde (MDA), and glutathione peroxidase (GPx) were measured; histopathological, histochemical, and immunohistochemical analyses were performed, including cleaved caspase-3 expression. \n\nResults: \nCCl\u2084 exposure significantly reduced HDL, increased LDL, elevated MDA, altered GPx activity, intensified caspase-3 staining, and caused marked testicular structural deterioration. Soybean supplementation ameliorated these effects, restoring lipid profiles, reducing oxidative markers, preserving testicular architecture, improving spermatogenesis, and mitigating caspase-3 expression. \n\nConclusion: \nOverall, soybean exerts antioxidant and immunoprotective effects against CCl\u2084-induced testicular damage, suggesting a potential dietary strategy to counteract reproductive toxicity.<\/jats:p>","DOI":"10.5455\/ovj.2026.v16.i3.37","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:30:31Z","timestamp":1775079031000},"page":"1808","source":"Crossref","is-referenced-by-count":0,"title":["&lt;b&gt;Attenuation of carbon tetrachloride-induced male reproductive damage in albino laboratory rats using varying concentrations of supplemented soybean&lt;\/b&gt;"],"prefix":"10.5455","volume":"16","author":[{"given":"Zeinab","family":"Al-Amgad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany","family":"El-Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Madkour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hend","family":"Al-Amgad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Basher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Elnagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Rehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franti\u0161ek","family":"Zigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Zigov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Jad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","container-title":["Open Veterinary Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.bibliomed.org\/fulltextpdf.php?mno=277757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:19:54Z","timestamp":1791483594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.openveterinaryjournal.com\/?mno=277757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5455\/ovj.2026.v16.i3.37","relation":{},"ISSN":["2226-4485"],"issn-type":[{"value":"2226-4485","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}