{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:31:07Z","timestamp":1794324667336,"version":"4.9.0"},"reference-count":132,"publisher":"ScopeMed","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":90,"URL":"https:\/\/www.openveterinaryjournal.com\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.5455\/ovj.2026.v16.i3.44","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:30:31Z","timestamp":1775079031000},"source":"Crossref","is-referenced-by-count":1,"title":["&lt;b&gt;Cholesterol and testosterone dynamics in a polycystic ovary syndrome animal model&lt;\/b&gt;"],"prefix":"10.5455","member":"3407","reference":[{"key":"ref1","unstructured":"Allan, C.M., Wang, Y ., Jimenez, M., Marshan, B.,"},{"key":"ref2","unstructured":"Spaliviero, J., Illingworth, P. and Handelsman, D.J."},{"key":"ref3","unstructured":"2006. Follicle-stimulating hormone increases the"},{"key":"ref4","unstructured":"reserve of the primordial follicle in mature female"},{"key":"ref5","unstructured":"hypogonadal mice. J. Endocrinol. 188, 549\u2013557."},{"key":"ref6","unstructured":"B\u00f6ttner, M., Leonhardt, S., Wuttke, W., Wedel, T. and"},{"key":"ref7","unstructured":"Jarry, H. 2010. Expression of estrogen receptors in"},{"key":"ref8","unstructured":"the hypothalamo-pituitary-ovarian axis in middle-"},{"key":"ref9","unstructured":"aged rats after re-instatement of estrus cyclicity."},{"key":"ref10","unstructured":"Biogerontology 11, 75\u201385."},{"key":"ref11","unstructured":"Cora, M.C., Kooistra, L. and Travlos, G. 2015. Vaginal"},{"key":"ref12","unstructured":"cytology of the laboratory rat and mouse: review"},{"key":"ref13","unstructured":"and criteria for the staging of the estrous cycle"},{"key":"ref14","unstructured":"using stained vaginal smears. Toxicol. Pathol. 43,"},{"key":"ref15","unstructured":"Delwatta, S.L., Gunatilake, M., Baumans, V .,"},{"key":"ref16","unstructured":"Seneviratne, M.D., Dissanayaka, M.L.B.,"},{"key":"ref17","unstructured":"Batagoda, S.S. Udagedara, A.H. and Walpola, P.B."},{"key":"ref18","unstructured":"2018 Reference values for selected hematological,"},{"key":"ref19","unstructured":"biochemical, and physiological parameters of"},{"key":"ref20","unstructured":"Sprague-Dawley rats at the Animal House, Faculty"},{"key":"ref21","unstructured":"of Medicine, University of Colombo, Sri Lanka."},{"key":"ref22","unstructured":"Animals 1, 250\u2013254."},{"key":"ref23","unstructured":"Dumesic, D.A., Oberfield, S.E., Stener-Victorin, E.,"},{"key":"ref24","unstructured":"Marshall, J.C., Laven, J.S. and Legro, R.S. 2015."},{"key":"ref25","unstructured":"Scientific statement on the diagnostic criteria,"},{"key":"ref26","unstructured":"epidemiology, pathophysiology, and molecular"},{"key":"ref27","unstructured":"genetics of PCOS. Endocr. Rev. 36, 487\u2013525."},{"key":"ref28","unstructured":"G\u00f6k\u00e7ek, I. and Uyan\u0131k, G. 2025. Protective effects"},{"key":"ref29","unstructured":"of thymol with hormonal, antiinflammatory and"},{"key":"ref30","unstructured":"antioxidant pathways in lipopolysaccharide-induced ovarian damage in rats. Vet. Sci. Practices"},{"key":"ref31","unstructured":"20(1), 1\u20137; doi:10.1016\/j.vsp.2025"},{"key":"ref32","unstructured":"Goodarzi, M.O., Dumesic, D.A., Chazenbalk, G."},{"key":"ref33","unstructured":"and Azziz, R. 2011. Polycystic ovary syndrome:"},{"key":"ref34","unstructured":"etiology, pathogenesis and diagnosis. Nat. Rev."},{"key":"ref35","unstructured":"Endocrinol. 7, 219\u2013231."},{"key":"ref36","unstructured":"Gunness, P., Williams, B.A., Gerrits, W.J.J., Bird, A.R.,"},{"key":"ref37","unstructured":"Kravchuk, O. and Gidley, M.J. 2016. Circulating"},{"key":"ref38","unstructured":"triglycerides and bile acids are reduced by a"},{"key":"ref39","unstructured":"soluble wheat arabinoxylan via modulation of bile"},{"key":"ref40","unstructured":"concentration and lipid digestion rates in a pig"},{"key":"ref41","unstructured":"model. Mol. Nutr. Food Res. 60, 642\u2013651."},{"key":"ref42","unstructured":"Harris, K., Herati, A., Andriole, G., Castro-Santamaria,"},{"key":"ref43","unstructured":"R., Freedland, S. and Moreira, D. 2020. Relationship"},{"key":"ref44","unstructured":"between endogenous testosterone and lipid"},{"key":"ref45","unstructured":"parameters: insight from REDUCE Study Group"},{"key":"ref46","unstructured":"database. J. Sexual. Med. 17(Suppl. 1), S22\u2013S23."},{"key":"ref47","unstructured":"Imamichi Y , Sekiguchi T, Kitano T, Kajitani T, Okada"},{"key":"ref48","unstructured":"R, Inaoka Y , Terashima M, Kuwahara A, Yamada,"},{"key":"ref49","unstructured":"K., and Miyamoto, K. 2017. Diethylstilbestrol"},{"key":"ref50","unstructured":"administration inhibits theca cell androgen and"},{"key":"ref51","unstructured":"granulosa cell estrogen production in immature rat"},{"key":"ref52","unstructured":"ovary. Sci Rep 2017;7:8374."},{"key":"ref53","unstructured":"Ishikawa, T., Glidewell-Kenney, C. and Jameson,"},{"key":"ref54","unstructured":"J. L. 2006. Aromatase-independent testosterone"},{"key":"ref55","unstructured":"conversion into estrogenic steroids is inhibited by"},{"key":"ref56","unstructured":"a 5\u03b1-reductase inhibitor. J. Steroid Biochem. Mol."},{"key":"ref57","unstructured":"Biol. 98(2), 133\u2013138."},{"key":"ref58","unstructured":"Jiang, Y . and Tian, W. 2017. The effects of progesterones"},{"key":"ref59","unstructured":"on blood lipids in hormone replacement therapy."},{"key":"ref60","unstructured":"Lipids Health Dis. 16, 219."},{"key":"ref61","unstructured":"Jin, J., Hu, Q., Xu, W., Zhu, W., Liu, B., Liu, J., Wang,"},{"key":"ref62","unstructured":"W. and Zhou, H. 2019. Tanshinone IIA attenuates"},{"key":"ref63","unstructured":"estradiol-induced polycystic ovarian syndrome"},{"key":"ref64","unstructured":"in mice by ameliorating FSHR expression in the"},{"key":"ref65","unstructured":"ovary. Exp. Ther. Med. 17, 3505\u20133507."},{"key":"ref66","unstructured":"Joham, A.E., Norman, R.J., Stener-Victorin, E., Legro,"},{"key":"ref67","unstructured":"R.S., Franks, S., Moran, L.J., Boyle, J., Teede,"},{"key":"ref68","unstructured":"H.J. and the International PCOS Network. 2022."},{"key":"ref69","unstructured":"Polycystic ovary syndrome. Lancet. Diabetes"},{"key":"ref70","unstructured":"Endocrinol. 10, 668\u2013680."},{"key":"ref71","unstructured":"Kurniawati, E.Y ., Pramono, N., Hidayat, S.T. and"},{"key":"ref72","unstructured":"Mahati, E. 2023. Assessment and experimental"},{"key":"ref73","unstructured":"procedure of the polycystic ovary syndrome"},{"key":"ref74","unstructured":"(PCOS) rat model: a review. J. Sain. P. Indones. 18,"},{"key":"ref75","unstructured":"Mukilan, R., Vijayaraman, M. and Subbiah, A.J. 2019."},{"key":"ref76","unstructured":"Dose determination of estradiol benzoate for PCOS"},{"key":"ref77","unstructured":"induction. Int. J. Pharm. Biol. Sci. 9, 1131\u20131136."},{"key":"ref78","doi-asserted-by":"crossref","unstructured":"Murphy, M.S. and O'Brien, T. 2009. Dyslipidemias.In","DOI":"10.1016\/B978-1-4160-3291-5.50027-5"},{"key":"ref79","unstructured":"Pharmacology and Therapeutics. Eds., Waldman,"},{"key":"ref80","unstructured":"S.A. and Terzic, A. Amsterdam, The Netherlands:"},{"key":"ref81","unstructured":"Oktanella, Y ., Untari, H., Wuragil, D., Agustina, G. and"},{"key":"ref82","unstructured":"Pratama, D. 2023. Evaluation of renal disturbance"},{"key":"ref83","unstructured":"in animal models of polycystic ovary syndrome."},{"key":"ref84","unstructured":"Open Vet. J. 13, 1003."},{"key":"ref85","unstructured":"http:\/\/www.openveterinaryjournal.com"},{"key":"ref86","doi-asserted-by":"crossref","unstructured":"Y. Oktanella et al.  Open Veterinary Journal , (2026), V ol. 16(3): 1885-1892","DOI":"10.5455\/OVJ.2026.v16.i3.44"},{"key":"ref87","unstructured":"1892Osuka, S., Nakanishi, N., Murase, T., Nakamura,"},{"key":"ref88","unstructured":"T., Goto, M., Iwase, A. and Kikkawa, F. 2019."},{"key":"ref89","unstructured":"Animal models of polycystic ovary syndrome:"},{"key":"ref90","unstructured":"a review of hormone-induced rodent models"},{"key":"ref91","unstructured":"focused on hypothalamus\u2013pituitary\u2013ovary axis and"},{"key":"ref92","unstructured":"neuropeptides. Reprod. Med. Biol. 18, 151\u2013160."},{"key":"ref93","unstructured":"Oyebanji, O.G., Asaolu, M.F. and Amonimo, E.O."},{"key":"ref94","unstructured":"2018. Hormonal imbalance in polycystic ovarian"},{"key":"ref95","unstructured":"syndrome in teaching hospitals in Ekiti, Nigeria."},{"key":"ref96","unstructured":"Open. J. Obstet. Gynecol. 8, 1456\u20131464."},{"key":"ref97","unstructured":"Palomba, S., Daolio, J. and La Sala, G.B. 2017. Oocyte"},{"key":"ref98","unstructured":"competence in polycystic ovary syndrome. Trends"},{"key":"ref99","unstructured":"Endocrinol. Metab. 28, 186\u2013198."},{"key":"ref100","unstructured":"Rocha, A.L., Oliveira, F.R., Azevedo, R.C., Silva, V .A.,"},{"key":"ref101","unstructured":"Peres, T.M., Candido, A.L., Gomes, K.B. and Reis,"},{"key":"ref102","unstructured":"F.M. 2019. Recent advances in understanding and"},{"key":"ref103","unstructured":"managing polycystic ovary syndrome F1000Res. 8,"},{"key":"ref104","unstructured":"Rosenfield, R.L. and Ehrmann, D.A. 2016. Pathogenesis"},{"key":"ref105","unstructured":"of polycystic ovary syndrome (PCOS): revision"},{"key":"ref106","unstructured":"of the hypothesis of PCOS as functional ovarian"},{"key":"ref107","unstructured":"hyperandrogenism. Endocr. Rev. 37, 467\u2013520."},{"key":"ref108","unstructured":"Spari\u0107, R., Zlatar, J., Nikoli\u0107, L., Opali\u0107-Palibrk,"},{"key":"ref109","unstructured":"M., Radi\u0107, L., Bjeki\u0107-Macut, J., Ognjanovi\u0107, S."},{"key":"ref110","unstructured":"and Macut, D. 2024. Clinical manifestations of polycystic ovary syndrome. Medicinska Istra\u017eivanja"},{"key":"ref111","unstructured":"57(4), 93\u2013102."},{"key":"ref112","doi-asserted-by":"crossref","unstructured":"Singh. 2005. Persistent estrus rat models of polycystic","DOI":"10.1016\/j.fertnstert.2005.06.013"},{"key":"ref113","unstructured":"ovary disease: an update. Fertil. Steril. 84, 1228\u2013"},{"key":"ref114","unstructured":"Strauss JF. 2019. Organization of ovarian steroidogenic"},{"key":"ref115","unstructured":"cells and cholesterol metabolism, 3rd ed. In The"},{"key":"ref116","unstructured":"Ovary. Eds., Leung, P.C.K. and Adashi, E.Y ."},{"key":"ref117","unstructured":"London,UK: Academic Press, pp. 83\u201394."},{"key":"ref118","unstructured":"Teede, H.J., Misso, M.L., Costello, M.F., Dokras,"},{"key":"ref119","unstructured":"A., Laven, J.S.E., Moran, L.J., Piltonen, T.,"},{"key":"ref120","unstructured":"Norman, R.J. and International PCOS Network."},{"key":"ref121","unstructured":"2018. Recommendations from the International"},{"key":"ref122","unstructured":"Evidence-Based Guideline for the Assessment and"},{"key":"ref123","unstructured":"Management of Polycystic Ovarian Syndrome."},{"key":"ref124","unstructured":"Hum. Reprod. 33, 1602\u20131618."},{"key":"ref125","unstructured":"Turza, A., Popescu, V ., Mare, L. and Borodi, G. 2022."},{"key":"ref126","unstructured":"Structural aspects and intermolecular energy for"},{"key":"ref127","unstructured":"some short testosterone esters. Mater. (Basel). 15,"},{"key":"ref128","unstructured":"Walters, K.A., Gilchrist, R.B., Ledger, W.L., Teede,"},{"key":"ref129","unstructured":"H.J., Handelsman, D.J. and Campbell, R.E. 2018."},{"key":"ref130","unstructured":"New Perspectives on the Pathogenesis of PCOS:"},{"key":"ref131","unstructured":"neuroendocrine Origins. Trends Endocrinol. Metab."},{"key":"ref132","unstructured":"29, 841\u2013852."}],"container-title":["Open Veterinary Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.bibliomed.org\/fulltextpdf.php?mno=303929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:30:24Z","timestamp":1792099824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.openveterinaryjournal.com\/?mno=303929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":132,"URL":"https:\/\/doi.org\/10.5455\/ovj.2026.v16.i3.44","relation":{},"ISSN":["2226-4485"],"issn-type":[{"value":"2226-4485","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}