{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:31:07Z","timestamp":1794324667856,"version":"4.9.0"},"reference-count":0,"publisher":"ScopeMed","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.openveterinaryjournal.com\/?sec=licenseinfo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Vet. J."],"abstract":"<jats:p>Background: \nThyroid disorders are associated with elevated reactive oxygen species (ROS) levels that trigger apoptosis. Nevertheless, the precise connection between ROS levels and apoptotic markers in thyroid dysfunction remains unclear. \n\nAim: \nTo explore the relationship between ROS levels and intrinsic apoptotic (IA) markers in thyroid homogenates derived from hypothyroidism and hyperthyroidism mouse models. \n\nMethods: \nEighteen male Wistar rats, each weighing 240 \u00b1 10 g, were allocated to three groups of six rats. Hypothyroidism and hyperthyroidism were induced over 8 weeks using 0.05% Propylthiouracil (PTU) and 0.0012% Levothyroxine (L-Thy), respectively. T3, T4, and thyroid-stimulating hormone (TSH) levels were measured, and thyroid size and body weights were recorded. The levels of ROS markers (MDA, GSH, SOD-1, CAT, and GPX) and IA markers (Bax, Bcl-2, and caspase-3) were assessed in tissue homogenates. \n\nResults: \nA gradual weight loss was observed in the hyperthyroidism group compared with the control group. The hypothyroid model showed elevated MDA levels and cleaved caspase-3, as well as a higher Bax\/Bcl-2 ratio, whereas GSH, SOD-1, CAT, GPX, and Bcl-2 levels were lower than those in the control group (P &amp;lt; 0.05). In contrast, no changes were observed in the hyperthyroid models. Thyroid hormone levels are inversely correlated with ROS and positively correlated with antioxidant levels. \n\nConclusion: \nHypothyroidism models exhibited increased oxidative stress and pro-apoptotic markers, suggesting the initiation of apoptosis and cellular damage. Conversely, the hyperthyroid models showed no such changes.<\/jats:p>","DOI":"10.5455\/ovj.2026.v16.i4.24","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T08:10:11Z","timestamp":1777795811000},"page":"2232-2243","source":"Crossref","is-referenced-by-count":1,"title":["&amp;lt;b&amp;gt;Reactive oxygen species and intrinsic apoptotic markers in thyroid dysfunction: Insights from experimental animal models&amp;lt;\/b&amp;gt;"],"prefix":"10.5455","author":[{"given":"Abdelmoneim","family":"Mekki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkarim","family":"Abdrabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3407","published-online":{"date-parts":[[2026]]},"container-title":["Open Veterinary Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.ejmanager.com\/fulltextpdf.php?mno=297672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:19:58Z","timestamp":1791483598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.openveterinaryjournal.com\/?mno=297672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5455\/ovj.2026.v16.i4.24","relation":{},"ISSN":["2226-4485"],"issn-type":[{"value":"2226-4485","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}