{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:04:32Z","timestamp":1761649472375,"version":"3.38.0"},"reference-count":0,"publisher":"Sociedad Argentina de Investigacion Odontologica","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Odontol Latinoam"],"abstract":"<jats:p>Oropharyngeal candidiasis (OC) is common among people living with HIV (PLWH). Persistent colonization\nof oral epithelial surfaces serves as an ecological niche for opportunistic pathogens and is a significant\npredisposing factor for OC development in PLWH. Mucosal colonization can lead to biofilm formation,\ndirectly impacting oral epithelium. Aim: To assess Candida albicans and Candida dubliniensis colonization\nin subgingival biofilms of people living with HIV (PLWH) and undergoing antiretroviral therapy (ART).\nMaterials and Method: A sample of 51 PLWH who were receiving ART was studied, focusing on dental and\nperiodontal parameters. Subgingival biofilm and mucosa samples were collected, and Candida spp. were\nidentified using molecular techniques. Results: Men (average age: 41.11 \u00b1 8.63) predominated. The main\ncause of HIV was sexual transmission. Fungal-related opportunistic diseases were observed in 18 patients,\nand LT CD4 counts were evaluated. A total 255 samples were collected, including 204 from gingivo-\nperiodontal sites and 51 from oral mucosa. Candida spp. was detected in 55% of patients, with particular\ndistribution patterns. Positive Candida spp. presence correlated with clinical attachment level and HIV\ntreatments. Microscopic identification revealed the presence of hyphae at the time of microbiological sample\ncollection. Molecular identification confirmed 16 Candida albicans and 36 Candida dubliniensis isolates,\nchallenging their diagnostic importance. Conclusions: The presence of yeast hyphae\/pseudohyphae in\nsubgingival biofilms indicates their role in gingivo-periodontal disease dysbiosis. PLWH in this Argentine\nregion face challenges including limited access to healthcare. The study underscores the need for early oral\nhealth intervention, emphasizing the diagnostic significance of Candida.<\/jats:p>","DOI":"10.54589\/aol.37\/3\/191","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T16:07:01Z","timestamp":1740931621000},"page":"191-202","source":"Crossref","is-referenced-by-count":1,"title":["Subgingival biofilm colonization by Candida albicans and Candida dubliniensis in patients living with HIV from Buenos Aires, Argentina"],"prefix":"10.54589","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6023-3103","authenticated-orcid":false,"given":"Ver\u00f3nica \u00c1","family":"Dubois","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4232-7178","authenticated-orcid":false,"given":"Pablo A","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-1872","authenticated-orcid":false,"given":"Susana L","family":"Molgatini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6716-4147","authenticated-orcid":false,"given":"Laura A","family":"Gliosca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31696","published-online":{"date-parts":[[2024]]},"container-title":["Acta Odontol\u00f3gica Latinoamericana"],"original-title":[],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T16:07:02Z","timestamp":1740931622000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaodontologicalat.com\/wp-content\/uploads\/2025\/02\/aol_2024_37_3_191.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.54589\/aol.37\/3\/191","relation":{},"ISSN":["1852-4834"],"issn-type":[{"value":"1852-4834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}