{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:29:25Z","timestamp":1791962965134,"version":"4.3.4"},"reference-count":0,"publisher":"Sociedad Argentina de Investigacion Odontologica","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Odontol Latinoam"],"abstract":"<jats:p>Cannabinoid receptors (CBr) 1 and 2 (CB1r and CB2r) are present in periodontal\n            tissues and salivary glands and play a significant role in the pathogenesis of oral\n            diseases. Aim: To study the gene expression of CB1r and CB2r in gingival tissue and\n            submandibular glands (SMG) of rats subjected to experimental periodontitis (EP) and\/or\n            hyposalivation (H), and discuss their possible implication in oral health. Material and\n            methods: Rats were divided into controls, rats with EP induced by application of\n            lipopolysaccharide (1 mg\/ml), rats with H induced by bilateral submandibulectomy, and\n            rats with both EP and H. Alveolar bone loss was measured with a digital caliper, mRNA\n            expression of CBr and bone parameters were determined by endpoint RT-PCR, PGE2 glandular\n            content was assessed by radioimmunoassay, and stimulated salivary secretion was\n            collected and weighed. Results: CB1r and CB2r mRNA in gingival tissue were upregulated\n            in groups EP, H and EP+H as compared to controls (CB1r (AU): C 0.27\u00b10.06A, EP\n            0.46\u00b10.05B, H 0.51\u00b10.08B, EP+H 0,49\u00b10,1B; CB2r (AU): C 0.38\u00b10.04A, EP 1.22\u00b10.08B, H\n            0.98\u00b10.06C, EP+H 1,041\u00b10,1BC). Groups EP, H and EP+H showed alveolar bone loss as\n            opposed to controls, while only groups EP and EP+H evidenced RANKL\/OPG imbalance\n            measured in the dental attachment tissue. Likewise, CB1r and CB2r mRNA in SMG showed\n            upregulation in group EP as compared to controls (CB1r (AU): C 0.52\u00b10.09A, EP\n            0.95\u00b10.13B; CB2 (AU): C 0.23\u00b10.12A, EP 1.48\u00b10.22B). In group EP, salivary secretion was\n            lower and the content of PGE2 (inhibitory mediator of said function) was higher than in\n            controls. Conclusion: The upregulation of CB2r in oral tissues under the\n            pathophysiological conditions studied suggests that they participate actively in the\n            response to oral diseases.<\/jats:p>","DOI":"10.54589\/aol.38\/2\/112","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:28:22Z","timestamp":1761859702000},"page":"112-121","source":"Crossref","is-referenced-by-count":1,"title":["Upregulation of cannabinoid receptor gene expression in oral tissues subjected to\n            hyposalivation and periodontitis"],"prefix":"10.54589","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3915-4226","authenticated-orcid":false,"given":"Noelia B","family":"Balcarcel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8093-4628","authenticated-orcid":false,"given":"Gast\u00f3n R","family":"Troncoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1938-6662","authenticated-orcid":false,"given":"Julia I","family":"Astrauskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5173-9719","authenticated-orcid":false,"given":"C\u00e9sar A","family":"Ossola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-3585","authenticated-orcid":false,"given":"Javier","family":"Fernandez-Solari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31696","published-online":{"date-parts":[[2025,8,30]]},"container-title":["Acta Odontol\u00f3gica Latinoamericana"],"original-title":[],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:49:42Z","timestamp":1761860982000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaodontologicalat.com\/wp-content\/uploads\/2025\/10\/aol_2025_38_2_112.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,8,30]]}},"URL":"https:\/\/doi.org\/10.54589\/aol.38\/2\/112","relation":{},"ISSN":["1852-4834"],"issn-type":[{"value":"1852-4834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,30]]}}}