{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T01:11:37Z","timestamp":1771981897459,"version":"3.50.1"},"reference-count":0,"publisher":"Sociedad Argentina de Investigacion Odontologica","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Odontol Latinoam"],"abstract":"<jats:p>Endodontic treatment offers a high success rate; however, the search for therapeutic alternatives that\npromote regeneration of the dentin-pulp complex has elicited great interest. Aim: The aim of this study\nwas to evaluate, in an in vivo model, the potential for dentin-pulp regeneration by transplantation of\nstem cells from two sources: pulp of human deciduous teeth and periosteum. Materials and Method:\nEighteen mesiobuccal canals of maxillary first molars of immunosuppressed rats were distributed into\nthree groups (n=6): group DT (deciduous teeth pulp), received stem cells from deciduous tooth pulp in\nhydrogel vehicle; group P (periosteal), received periosteal stem cells in hydrogel vehicle; and group NC\n(negative control) received only hydrogel. After pulpectomy and canal preparation, the teeth received\nthe respective materials, and the cavities were sealed. After 12 weeks, the animals were euthanized\nand the specimens underwent histological processing and qualitative evaluation of intracanal fibrous\nconnective tissue, odontoblast-like cells, intracanal mineralized tissue, and inflammatory cell infiltrate.\nResults: In the NC group, abundant presence of inflammatory cells was observed throughout the canal,\nin addition to dentin chips and remnants of amorphous substance from pulp tissue. In groups DT and\nP, in the apical region, new tissue formation suggestive of repair was observed, with deposition of\nbone-like mineralized tissue and periodontal ligament-like connective tissue containing blood vessels\nand osteocyte- and fibroblast-like cells. Conclusions: Transplanted stem cells from pulp of human\ndeciduous teeth and periosteum did not show potential for regeneration, but for tissue repair, with\nformation of periodontal ligament-like and bone-like tissue.<\/jats:p>","DOI":"10.54589\/aol.38\/3\/216","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:52:15Z","timestamp":1771980735000},"page":"216-224","source":"Crossref","is-referenced-by-count":0,"title":["Histological evaluation of dentin\u2013pulp tissue response after transplantation of stem cells from periosteum and human deciduous teeth and in rats"],"prefix":"10.54589","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1047-2741","authenticated-orcid":false,"given":"Tainara B","family":"Yamanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2396-1587","authenticated-orcid":false,"given":"Randro M","family":"Rajab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-2121","authenticated-orcid":false,"given":"Rina A","family":"Pelegrine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2675-0884","authenticated-orcid":false,"given":"Carlos E","family":"da Silveira Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3320-9172","authenticated-orcid":false,"given":"Alexandre","family":"Sigrist De Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-558X","authenticated-orcid":false,"given":"Carolina","family":"Pessoa Stringheta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4991-1185","authenticated-orcid":false,"given":"Elizabeth","family":"Ferreira Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-6839","authenticated-orcid":false,"given":"Carlos E","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-4923","authenticated-orcid":false,"given":"S\u00e9rgio L","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-2260","authenticated-orcid":false,"given":"Daniel","family":"Guimar\u00e3es Pedro Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0257-9218","authenticated-orcid":false,"given":"Larissa Regina","family":"Kuntze dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-1062","authenticated-orcid":false,"given":"Andr\u00e9 A","family":"Pelegrine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31696","published-online":{"date-parts":[[2025,12,30]]},"container-title":["Acta Odontol\u00f3gica Latinoamericana"],"original-title":[],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:52:17Z","timestamp":1771980737000},"score":1,"resource":{"primary":{"URL":"https:\/\/actaodontologicalat.com\/wp-content\/uploads\/2026\/02\/aol_2025_38_3_216.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,12,30]]}},"URL":"https:\/\/doi.org\/10.54589\/aol.38\/3\/216","relation":{},"ISSN":["1852-4834"],"issn-type":[{"value":"1852-4834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]}}}