{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:32:51Z","timestamp":1776133971699,"version":"3.50.1"},"reference-count":24,"publisher":"Korean Society of Obstetrics and Gynecology","issue":"4","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ogscience.org"],"crossmark-restriction":true},"short-container-title":["Obstet Gynecol Sci"],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"Objective Does the timing of cabergoline administration impact the rate of mild\/moderate ovarian hyperstimulation syndrome in women with a GnRH agonist trigger?Methods We conducted a retrospective cohort analysis of 285 <i>in-vitro<\/i> fertilization patients at risk of OHSS who received a GnRH agonist trigger from 2011 to 2019 at McGill University Health Centre. Group 1 (Trig, n=101) began taking cabergoline 0.5 mg orally for 7 days at the time of GnRH agonist trigger, while Group 2 (Retriev, n=184) started taking cabergoline on the day of oocyte retrieval. The rates of OHSS were then compared between the groups using analysis of variance and chi-square analysis, where appropriate.Results The baseline demographic characteristics of the two groups were similar. Trig appeared to be at a slightly higher risk of OHSS based on a significantly higher antral follicle count (20.2\u00b14.2 vs. 19.0\u00b14.3; <i>P<\/i>=0.02), higher number of stimulated follicles >10 mm at trigger (25.7\u00b17.0 vs. 22.8\u00b18.3, <i>P<\/i>=0.003), and higher peak serum E2 level (17,325\u00b12,542 vs. 14,822\u00b13,098; <i>P<\/i>=0.0001). The Trig group had lower rates of mild and moderate OHSS (24% vs. 36%; <i>P<\/i>=0.045). Neither group had any patients who developed severe OHSS. Trig had fewer patients presenting with pelvic free fluid (13% vs. 23%; <i>P<\/i>=0.03), lower hematocrit (37.8\u00b14.8% vs. 40.5\u00b14.2%; <i>P<\/i>=0.0001), higher albumin concentrations (30.4\u00b12.7 vs. 29.5\u00b12.0; <i>P<\/i>=0.01), and lower potassium concentrations (3.9\u00b10.5 vs. 4.2\u00b10.7; <i>P<\/i>=0.0002).Conclusion Cabergoline at the time of trigger as compared to the time of collection should be investigated to assess its role in reducing the rates of mild\/moderate OHSS.<\/jats:p>","DOI":"10.5468\/ogs.21067","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T04:25:23Z","timestamp":1623212723000},"page":"345-352","update-policy":"https:\/\/doi.org\/10.5468\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does the timing of cabergoline administration impact rates of ovarian hyperstimulation syndrome?"],"prefix":"10.5468","volume":"64","author":[{"given":"Eryn Sara","family":"Rubenfeld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-7708","authenticated-orcid":true,"given":"Michael Haim","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3425","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s1472-6483(10)60452-x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s1701-2163(15)30417-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.04.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.01.019"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.07.022"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.170415"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd008605.pub2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.08.008"},{"key":"ref9","first-page":"3222","volume-title":"Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants","author":"Gille","year":"2001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0770.165121"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137613"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/14647273.2013.833348"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.11.005"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd008605.pub3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.03.002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1172\/jci200318740"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2019.03.005"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem315"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.05.018"},{"key":"ref20","first-page":"19","volume-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","year":"2004"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det124"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det288"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0334-9"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(16)55188-7"}],"container-title":["Obstetrics & Gynecology Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ogscience.org\/upload\/pdf\/ogs-21067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ogscience.org\/journal\/view.php?doi=10.5468\/ogs.21067","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ogscience.org\/upload\/pdf\/ogs-21067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T02:22:02Z","timestamp":1626229322000},"score":1,"resource":{"primary":{"URL":"http:\/\/ogscience.org\/journal\/view.php?doi=10.5468\/ogs.21067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,15]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"URL":"https:\/\/doi.org\/10.5468\/ogs.21067","relation":{},"ISSN":["2287-8580"],"issn-type":[{"value":"2287-8580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,15]]},"assertion":[{"value":"2021-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-09","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}