{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:18:09Z","timestamp":1789683489995,"version":"4.0.1"},"reference-count":29,"publisher":"Korean Society of Obstetrics and Gynecology","issue":"3","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["18041"],"award-info":[{"award-number":["18041"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ogscience.org"],"crossmark-restriction":true},"short-container-title":["Obstet Gynecol Sci"],"published-print":{"date-parts":[[2022,5,15]]},"abstract":"<jats:p>Objective Recurrent pregnancy loss (RPL) is a fertility problem for which no exact mechanism of abortion or efficient treatment has been described. This study was conducted between 2018 and 2019 to investigate the effectiveness of autologous platelet-rich plasma (PRP) in improving the live birth rate of women with RPL who required &lt;i&gt;in vitro&lt;\/i&gt; fertilization (IVF).Methods A total of 63 patients with at least two previous pregnancy losses and no specific cause detected for the RPL were included and randomly assigned into two groups (PRP and control). Intrauterine infusion of 0.5 mL of autologous PRP was performed 48 hours before embryo transfer in the PRP group. Women in the control group received standard treatment.Results Forty patients completed the study. The baseline and cycle characteristics of the participants did not differ significantly between the PRP and control groups. The clinical pregnancy rate was higher in the PRP group (35% vs. 20%, &lt;i&gt;P&lt;\/i&gt;=0.288). The live birth rate was 15% in the PRP group, but no live births were recorded in the control group (&lt;i&gt;P&lt;\/i&gt;=0.231).Conclusion This is the first study to show that intrauterine infusion of PRP in patients with RPL who undergo IVF may increase the chance of live birth.<\/jats:p>","DOI":"10.5468\/ogs.21261","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T02:07:05Z","timestamp":1648519625000},"page":"266-272","update-policy":"https:\/\/doi.org\/10.5468\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of autologous platelet-rich plasma for treatment of recurrent pregnancy loss: a randomized controlled trial"],"prefix":"10.5468","volume":"65","author":[{"given":"Leila","family":"Nazari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saghar","family":"Salehpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedighe","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teibeh","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrin","family":"Borumandnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-4481","authenticated-orcid":true,"given":"Elham","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3425","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew169"},{"key":"ref2","volume-title":"","author":"Bender Atik","year":"2018"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215332"},{"key":"ref4","first-page":"e13153","volume-title":"Effect of alpha-lipoic acid and myoinositol on endometrial inflammasome from recurrent pregnancy loss women","author":"Di Nicuolo","year":"2019"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.21264"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.5455\/2320-1770.ijrcog20131201"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.11.022"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2014.10.008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2003.10.004"},{"key":"ref10","first-page":"52","volume-title":"A subset of patients with recurrent spontaneous abortion is deficient in transforming growth factor beta-2-producing \u201csuppressor cells\u201d in uterine tissue near the placental attachment site","author":"Lea","year":"1995"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133319"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.03.003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-7271-0_8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053\/j.otsm.2011.04.002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-7271-0_1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2019.1569268"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.14390\/jsshp.hrp2018-012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.19127\/mbsjohs.544429"},{"key":"ref19","first-page":"625","volume-title":"Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: a pilot study","author":"Nazari","year":"2016"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2019.1597344"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.01.166"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v17i6.4816"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00061"},{"key":"ref24","first-page":"5873","volume-title":"Platelet rich plasma in repeated implantation failure in women with thin endometrium thickness","author":"El Hamedi","year":"2019"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.5935\/1518-0557.20170013"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.5935\/1518-0557.20180009"},{"key":"ref27","first-page":"2869","volume-title":"The value of using platelet rich plasma after hysteroscopic analysis of severe intrauterine adhesions (a randomized controlled trial)","author":"Torky","year":"2018"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der376"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-9006-9_9"}],"container-title":["Obstetrics &amp; 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