{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:11:57Z","timestamp":1791562317779,"version":"4.3.4"},"reference-count":40,"publisher":"Korean Society of Obstetrics and Gynecology","issue":"5","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ogscience.org"],"crossmark-restriction":true},"short-container-title":["Obstet Gynecol Sci"],"published-print":{"date-parts":[[2022,9,15]]},"abstract":"<jats:p>ObjectiveTo determine the value of endometrial thickness (ET) and Doppler indices of uterine artery (UtA) as sonographic markers in predicting endometrial cancer (EC) among postmenopausal bleeding (PMB) women in low-resource settings as Vietnam.MethodsThis cross-sectional study was conducted at the Hue University Hospital and Hue Central Hospital between June 2016 and June 2019. The study enrolled all women who complained of PMB and were followed by transvaginal Doppler ultrasound. Their definitive histopathological examination was the gold standard for comparison.ResultsThe UtA Doppler indices, including resistance index (RI), pulsatility index (PI), and peak systolic velocity (PSV), were significantly lower in the malignant group than in the benign group. The threshold values of the UtA, RI \u22640.73 and PI \u22641.42, were found with an area under receiver operating characteristic curve (AUC) of 0.85-0.88, and the sensitivity and specificity were 91.3% and 83.3%, respectively. Unlike PSV, the diagnostic value was the lowest, with an AUC of 0.72. ET was a good predictor for the diagnosis of EC, with an AUC of 0.89. In women with PMB, when using the cutoff value of EC more than 12.5 mm, the sensitivity and specificity were 93.8% and 77.8%, respectively. In addition, the higher the stage of EC, the lower the RI and PI and the greater the EC.ConclusionET, and RI, PI, and PSV of the UtA could help in differentiating malignant from benign endometrial changes. Pulsed ultrasonic Doppler velocimetry seems to play a role in predicting the higher stages of EC. Further studies are needed to confirm these findings.<\/jats:p>","DOI":"10.5468\/ogs.22053","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T02:25:12Z","timestamp":1651199112000},"page":"430-440","update-policy":"https:\/\/doi.org\/10.5468\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Endometrial thickness and uterine artery Doppler parameters as soft markers for prediction of endometrial cancer in postmenopausal bleeding women: a cross-sectional study at tertiary referral hospitals from Vietnam"],"prefix":"10.5468","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6473-7755","authenticated-orcid":true,"given":"Phuc Nhon","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Tuan","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3425","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0668-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/tog.12722"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s1701-2163(16)35020-4"},{"key":"ref5","first-page":"11","volume-title":"The incidence and mortality of endometrial cancer and its association with body mass index and human development index in asian population","author":"Khazaei","year":"2018"},{"key":"ref6","volume-title":"","author":"Hoffman","year":"2012"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.21116"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10208"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20161895"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2021.102209"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_259_20"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5073944"},{"key":"ref13","volume-title":"","author":"Grang\u00e9","year":"2016"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7487"},{"key":"ref15","volume-title":"","author":"Potier","year":"1997"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12371"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5114\/pm.2017.70589"},{"key":"ref18","first-page":"S64","volume-title":"Endometrial carcinoma diagnosis: use of FIGO grading and genomic subcategories in clinical practice: recommendations of the International Society of Gynecological Pathologists","author":"Soslow","year":"2019"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/igc.0b013e31820cc305"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.9790\/0853-131118289"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-002-0364-x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2011.07.003"},{"key":"ref23","first-page":"e14464","volume-title":"Risk of malignancies among asymptomatic postmenopausal women with thickened endometrium: a cohort study","author":"Li","year":"2019"},{"key":"ref24","first-page":"15","volume-title":"Study of endometrial volume and vascularity by 3D power doppler ultrasound in women with perimenopausal bleeding","author":"Ahmed","year":"2017"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrnm.2014.11.014"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07050315.x"},{"key":"ref27","first-page":"134","volume-title":"A study of endometrial pathology by transvaginal color doppler ultrasonography and its correlation with histopathology in post-menopausal women","author":"Bano","year":"2013"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/s0020-7292(02)00374-0"},{"key":"ref29","first-page":"722","volume-title":"Endometrial thickness and Doppler velocimetry of the uterine arteries as discriminators of endometrial status in women with postmenopausal bleeding: a comparative study","author":"Sladkevicius","year":"1994"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2019.62.6.445"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002631"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/850812"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20172930"},{"key":"ref34","first-page":"57","volume-title":"The impact of two &amp; 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