{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:36:05Z","timestamp":1740170165892,"version":"3.37.3"},"reference-count":21,"publisher":"Korean Society of Obstetrics and Gynecology","issue":"1","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ogscience.org"],"crossmark-restriction":true},"short-container-title":["Obstet Gynecol Sci"],"published-print":{"date-parts":[[2024,1,15]]},"abstract":"<jats:p>Objective To analyze tumour response and toxicity with respect to cumulative radiotherapy dose to target and organs at risk (OARs) with computed tomography (CT)-based image guided adaptive brachytherapy planning for locally advanced carcinoma cervix.Methods Patients were treated with two-dimensional concurrent chemoradiotherapy to whole pelvis followed by intracavitary brachytherapy (ICBT) with dose prescription to point \u2018A\u2019. CT image-based delineation of high-risk clinical target volume (HR-CTV), urinary bladder, rectum and sigmoid colon was done with generation of dose-volume histogram (DVH) data and optimization of doses to target and OARs. Follow up assessments were done for response of disease and toxicity with generation of data for statistical analysis.Results One hundred thirty-six patients were enrolled in the study. Delineated volume of HR-CTV ranged from 20.9 to 37.1 mL, with median value of 30.2 mL. The equivalent dose in 2 Gy per fraction (EQD2) for point \u2018A\u2019 ranged from 71.31 to 79.75 Gy with median value of 75.1 Gy and EQD2 HR-CTV D&lt;sub&gt;90&lt;\/sub&gt; ranged from 71.9 to 89.7 Gy with median value of 85.1 Gy. 69.2% of patients showed complete response and after median follow-up of 25 months, 50 patients remained disease free, of whom, 74.0% had received \u226585 Gy to HR-CTV D&lt;sub&gt;90&lt;\/sub&gt; versus 26.0% receiving &lt;85 Gy to HR-CTV D&lt;sub&gt;90&lt;\/sub&gt;.Conclusions Amidst the unavailability of magnetic resonance imaging facilities in low middle income countries, incorporation of CT-image based treatment planning into routine practice for ICBT provides the scope to delineate volumes of target and OARs and to generate DVH data, which can prove to be a better surrogate for disease response and toxicity.<\/jats:p>","DOI":"10.5468\/ogs.23048","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:38:00Z","timestamp":1697002680000},"page":"67-75","update-policy":"https:\/\/doi.org\/10.5468\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcome after high dose rate intracavitary brachytherapy with traditional point \u2018A\u2019 dose prescription in locally advanced carcinoma of uterine cervix: dosimetric analysis from the perspective of computed tomography imaging-based 3-dimensional treatment planning"],"prefix":"10.5468","volume":"67","author":[{"given":"Suman","family":"Dhabal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saikat","family":"Sau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4195-0622","authenticated-orcid":true,"given":"Sourav","family":"Sau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradip Kumar","family":"Maiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay","family":"Chakravarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3425","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"volume-title":"","year":"c1985","key":"ref2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.01.043"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.12.015"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.11.014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jicru_ndw027"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/s0360-3016(00)00497-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2011.07.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.06.005"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.12.021"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2011.07.002"},{"key":"ref12","first-page":"241","volume-title":"Dosimetric impact of point A definition on high-dose-rate brachytherapy for cervical cancer: evaluations on conventional point A and MRI-guided, conformal plans","author":"Anderson","year":"2012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.02.040"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.meddos.2010.02.009"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.21308"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.04.012"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.07.012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.11.002"},{"key":"ref19","first-page":"73","volume-title":"Pattern of failure with locally advanced cervical cancer- a retrospective audit and analysis of contributory factors","author":"Bandyopadhyay","year":"2018"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-28-95"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1017\/s1460396916000133"}],"container-title":["Obstetrics &amp; 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