{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:06:07Z","timestamp":1791986767491,"version":"4.4.0"},"reference-count":129,"publisher":"Korean Society of Obstetrics and Gynecology","issue":"4","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ogscience.org"],"crossmark-restriction":true},"short-container-title":["Obstet Gynecol Sci"],"published-print":{"date-parts":[[2024,7,15]]},"abstract":"<jats:p>This study aimed to summarize the current knowledge on the benefits of in vitro fertilization\/intracytoplasmic sperm injection with preimplantation genetic testing for aneuploidy (PGT-A) and to discuss the role of PGT-A in patients of different ages undergoing assisted reproduction. A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 checklist. Registration number: CRD42022354697. Studies were identified by searching the PubMed, Cochrane Library, Google Scholar, Scopus, Embase, and ClinicalTrials databases. Seven meta-analyses were performed with additional stratification of age and prognosis of the women studied. Clinical pregnancy rate per embryo transfer in patients aged &gt;35 years was higher in the PGT-A group (&lt;i&gt;P&lt;\/i&gt;=0.0002) than in controls. Live birth rate (LBR) per embryo transfer in women 35 years old or younger (&lt;i&gt;P&lt;\/i&gt;=0.002) was higher in the PGT-A group. The LBR per patient in women aged &gt;35 years was higher in the PGT-A group (&lt;i&gt;P&lt;\/i&gt;=0.004). The effects of PGT-A on LBR in patients with poor prognosis showed a statistically significant increase (&lt;i&gt;P&lt;\/i&gt;=0.003). There was no significant difference in the rate between the two groups. PGT-A is effective and can be recommended for patients aged &gt;35 years undergoing assisted reproduction to improve their reproductive outcomes. Moreover, our study showed the possible benefits of PGT-A in patients with a poor prognosis. Overall, our findings suggest that PGT-A is a valuable tool for improving the reproductive outcomes of assisted reproductive procedures in older women and those with a history of pregnancy complications.<\/jats:p>","DOI":"10.5468\/ogs.24028","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T07:29:10Z","timestamp":1716881350000},"page":"356-379","update-policy":"https:\/\/doi.org\/10.5468\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Preimplantation genetic testing for aneuploidy in patients of different age: a systematic review and meta-analysis"],"prefix":"10.5468","volume":"67","author":[{"given":"Leila","family":"Adamyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-3321","authenticated-orcid":true,"given":"Laura","family":"Pivazyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Obosyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Krylova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapiyat","family":"Isaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3425","reference":[{"key":"ref1","first-page":"1936","volume-title":"What is the most relevant standard of success in assisted reproduction?","author":"Heijnen","year":"2004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.11.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.06.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq344"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.07.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep059"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd005291"},{"key":"ref8","first-page":"89","volume-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","author":"Page","year":"2021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa017"},{"key":"ref10","volume-title":""},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.08.1267"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.08.1207"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.08.763"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.03.017"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.03.035"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.07.661"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.07.1072"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.04.035"},{"key":"ref21","volume-title":""},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4103\/2096-2924.281852"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa161"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01609-4"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01874-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02266-2"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab117"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey346"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.02.026"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1080\/19396368.2021.1954725"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa067744"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfre.2022.05.004"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.8.1762"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh536"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.875"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den217"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den367"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129958"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(03)00605-8"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.08.010"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.02.162"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.05.029"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.10.072"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.11.041"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(99)00377-5"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/s1472-6483(10)60414-2"},{"key":"ref47","volume-title":""},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02588-9"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.09.011"},{"key":"ref50","volume-title":""},{"key":"ref51","volume-title":""},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.08.033"},{"key":"ref53","first-page":"186","volume-title":"Association between clinical and IVF laboratory parameters and miscarriage after single euploid embryo transfers","author":"Del Carmen Nogales","year":"2021"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2018.1551628"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01496-9"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05084-1"},{"key":"ref57","volume-title":""},{"key":"ref58","volume-title":""},{"key":"ref59","volume-title":""},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00519-0"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.858042"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.03.026"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.12.034"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12960"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den129"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2022.03.022"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd005291.pub3"},{"key":"ref68","first-page":"1","volume-title":"Preimplantation genetic testing for aneuploidy: current perspectives","author":"L\u2019Heveder","year":"2021"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2019.01.013"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118820474"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8166-5-24"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0417-7"},{"key":"ref73","first-page":"2047","volume-title":"Live birth with or without preimplantation genetic testing for aneuploidy","author":"Yan","year":"2021"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01765-y"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00542-1"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02349-0"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.07.052"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.03.011"},{"key":"ref79","first-page":"1071","volume-title":"Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial","author":"Munn\u00e9","year":"2019"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-01399-1"},{"key":"ref81","first-page":"2340","volume-title":"Preimplantation genetic testing for aneuploidy: a comparison of live birth rates in patients with recurrent pregnancy loss due to embryonic aneuploidy or recurrent implantation failure","author":"Sato","year":"2019"},{"key":"ref82","first-page":"2548","volume-title":"Donor oocyte recipients do not benefit from preimplantation genetic testing for aneuploidy to improve pregnancy outcomes","author":"Doyle","year":"2020"},{"key":"ref83","first-page":"1507","volume-title":"Single center validation of routine blastocyst biopsy implementation","author":"Whitney","year":"2016"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.01.010"},{"key":"ref85","first-page":"1321","volume-title":"Effect of trophectoderm biopsy for PGT-A on live birth rate per embryo in good prognosis patients","author":"Awadalla","year":"2022"},{"key":"ref86","first-page":"2909","volume-title":"Preimplantation genetic testing for aneuploidies does not increase success rates in fresh oocyte donation cycles: a paired cohort study","author":"Martello","year":"2021"},{"key":"ref87","first-page":"1341","volume-title":"The impact of preimplantation genetic testing for aneuploidies (PGT-A) on clinical outcomes in high risk patients","author":"Pantou","year":"2022"},{"key":"ref88","first-page":"55","volume-title":"Risk-of-bias VISualization (robvis): an R package and shiny web app for visualizing risk-of-bias assessments","author":"McGuinness","year":"2021"},{"key":"ref89","first-page":"734","volume-title":"Adenosine triphosphate content in human unfertilized oocytes, undivided zygotes and embryos unsuitable for transfer or cryopreservation","author":"Zhao","year":"2012"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.07.1233"},{"key":"ref91","first-page":"1003","volume-title":"Whole exome sequencing in unexplained recurrent miscarriage families identified novel pathogenic genetic causes of euploid miscarriage","author":"Wang","year":"2023"},{"key":"ref92","first-page":"316","volume-title":"Effect of maternal age on pregnancy or neonatal outcomes among 4,958 infertile women using a freeze-all strategy","author":"Lin","year":"2020"},{"key":"ref93","first-page":"245","volume-title":"Effect of advanced paternal age on reproductive outcomes in IVF cycles of non-male-factor infertility: a retrospective cohort study","author":"Lu","year":"2023"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz050"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2020.05.005"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2019.103731"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3245"},{"key":"ref98","first-page":"669","volume-title":"Preimplantation genetic testing for aneuploidy (PGT-A)-finally revealed","author":"Orvieto","year":"2020"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-020-00616-w"},{"key":"ref100","first-page":"hoaa020","volume-title":"ESHRE PGT consortium and SIG embryology good practice recommendations for polar body and embryo biopsy for PGT","author":"Kokkali","year":"2020"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.04.039"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.23736\/S2724-606X.22.05196-X"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.01.051"},{"key":"ref104","first-page":"760","volume-title":"Validation of next-generation sequencing for comprehensive chromosome screening of embryos","author":"Kung","year":"2015"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.12.017"},{"key":"ref106","first-page":"223","volume-title":"Chromosome mosaicism in cleavage-stage human embryos: evidence of a maternal age effect","author":"Munn\u00e9","year":"2002"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmh005"},{"key":"ref108","first-page":"685","volume-title":"Fluorescence in situ hybridization analysis of two blastomeres from day 3 frozen-thawed embryos followed by analysis of the remaining embryo on day 5","author":"Baart","year":"2004"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei291"},{"key":"ref110","first-page":"117","volume-title":"Analysis of the evolution of chromosome abnormalities in human embryos from day 3 to 5 using CGH and FISH","author":"Daphnis","year":"2008"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2007.11.009"},{"key":"ref112","first-page":"19","volume-title":"PGDIS position statement on the transfer of mosaic embryos 2021","author":"Leigh","year":"2022"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-023-02763-6"},{"key":"ref114","first-page":"33","volume-title":"A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use","author":"Gleicher","year":"2017"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey106"},{"key":"ref116","first-page":"e1","volume-title":"PGDIS position statement on the transfer of mosaic embryos 2019","author":"Cram","year":"2019"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.07.452"},{"key":"ref118","first-page":"246","volume-title":"Clinical management of mosaic results from preimplantation genetic testing for aneuploidy (PGT-A) of blastocysts: a committee opinion","author":"Committee","year":"2020"},{"key":"ref119","first-page":"hoac044","volume-title":"ESHRE survey results and good practice recommendations on managing chromosomal mosaicism","author":"De Rycke","year":"2022"},{"key":"ref120","first-page":"368","volume-title":"Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis","author":"Maheshwari","year":"2012"},{"key":"ref121","first-page":"1953","volume-title":"Paternal factors contributing to embryo quality","author":"Colaco","year":"2018"},{"key":"ref122","first-page":"e12847","volume-title":"Fluorescence in situ hybridisation sperm examination is significantly impaired in all categories of male infertility","author":"Petousis","year":"2018"},{"key":"ref123","first-page":"21","volume-title":"High aneuploidy rates observed in embryos derived from donated oocytes are related to male aging and high percentages of sperm DNA fragmentation","author":"Garc\u00eda-Ferreyra","year":"2015"},{"key":"ref124","first-page":"26","volume-title":"High percentages of embryos with 21, 18 or 13 trisomy are related to advanced paternal age in donor egg cycles","author":"Garc\u00eda-Ferreyra","year":"2018"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.01.025"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.07.022"},{"key":"ref127","first-page":"573","volume-title":"A cost-effectiveness analysis of preimplantation genetic testing for aneuploidy (PGT-A) for up to three complete assisted reproductive technology cycles in women of advanced maternal age","author":"Lee","year":"2019"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.03.020"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02612-y"}],"container-title":["Obstetrics &amp; Gynecology Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ogscience.org\/upload\/pdf\/ogs-24028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ogscience.org\/journal\/view.php?doi=10.5468\/ogs.24028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ogscience.org\/upload\/pdf\/ogs-24028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T05:45:11Z","timestamp":1721367911000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ogscience.org\/journal\/view.php?doi=10.5468\/ogs.24028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,15]]},"references-count":129,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"URL":"https:\/\/doi.org\/10.5468\/ogs.24028","relation":{},"ISSN":["2287-8580"],"issn-type":[{"value":"2287-8580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,15]]},"assertion":[{"value":"2024-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-28","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}