{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T02:55:45Z","timestamp":1782528945140,"version":"3.54.5"},"reference-count":19,"publisher":"Korean Society of Obstetrics and Gynecology","issue":"5","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ogscience.org"],"crossmark-restriction":true},"short-container-title":["Obstet Gynecol Sci"],"published-print":{"date-parts":[[2024,9,15]]},"abstract":"<jats:p>Trisomy 9 is a rare chromosomal abnormality that occurs in both mosaic and non-mosaic states. The present study reports a case of mosaic trisomy 9 detected during pregnancy in a 41-year-old woman in the second trimester screening. Maternal serum screening results were used to diagnose a chromosomal abnormality in utero. The results were validated by karyotyping. High levels of alpha-fetoprotein and low levels of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and inhibin A indicate a high risk for chromosomal abnormalities, including trisomy 18. Amniotic fluid karyotyping revealed 47, XX, +9 (30)\/46, XX (20) in the fetus. Because a high level (60%) of mosaicism for trisomy 9 in the fetus can affect many parts of the body, the pregnancy was terminated. It seems that a significant reduction in the levels of hCG and uE3 is an informative marker for the detection of chromosomal abnormalities such as trisomy 9.<\/jats:p>","DOI":"10.5468\/ogs.24062","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T23:38:26Z","timestamp":1724801906000},"page":"506-510","update-policy":"https:\/\/doi.org\/10.5468\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Detection of trisomy 9 mosaicism in the second trimester screening by abnormal level of biochemical markers"],"prefix":"10.5468","volume":"67","author":[{"given":"Zohre","family":"Salari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4502-6015","authenticated-orcid":true,"given":"Mahdiyeh","family":"Moudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohre","family":"Mousavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3425","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.10.2.184"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1121121"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994561"},{"key":"ref4","first-page":"455","volume-title":"Second-trimester diagnosis of complete trisomy 9 associated with abnormal maternal serum screen results, open sacral spina bifida and congenital diaphragmatic hernia, and review of the literature","author":"Chen","year":"2004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33928"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2005.05.011"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98928-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0223(199811)18:11<1212::aid-pd430>3.3.co;2-s"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.57264\/cer-2022-0168"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-023-05428-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5212"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-023-06052-z"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23514"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080\/713605935"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/379534"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s1028-4559(10)60071-x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2011.10.031"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970131016"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.2229"}],"container-title":["Obstetrics &amp; Gynecology Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ogscience.org\/upload\/pdf\/ogs-24062.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ogscience.org\/journal\/view.php?doi=10.5468\/ogs.24062","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ogscience.org\/upload\/pdf\/ogs-24062.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T06:06:42Z","timestamp":1727158002000},"score":1,"resource":{"primary":{"URL":"http:\/\/ogscience.org\/journal\/view.php?doi=10.5468\/ogs.24062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,15]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"URL":"https:\/\/doi.org\/10.5468\/ogs.24062","relation":{},"ISSN":["2287-8580"],"issn-type":[{"value":"2287-8580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,15]]},"assertion":[{"value":"2024-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-27","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}