{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T04:06:18Z","timestamp":1747973178612,"version":"3.41.0"},"reference-count":22,"publisher":"Korean Society of Obstetrics and Gynecology","issue":"3","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ogscience.org"],"crossmark-restriction":true},"short-container-title":["Obstet Gynecol Sci"],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:p>ObjectiveThis study aimed to systematically evaluate potential causal relationships between nine cathepsins and female infertility using Mendelian randomization (MR) methods.MethodsA bidirectional MR analysis was conducted utilizing single nucleotide polymorphisms as instrumental variables to investigate the potential causal effects between nine cathepsins and female infertility. Genetic data on female infertility were sourced from the FinnGen study, and cathepsin-related data were obtained from genome-wide association studies datasets of European ancestry.ResultsElevated levels of cathepsin E were significantly and inversely associated with the risk of female infertility, suggesting a potential protective role. This finding was further supported by multivariable MR analysis. However, no significant associations were observed between the other eight cathepsins and female infertility.ConclusionThis study represents the first systematic MR analysis to identify a potential protective effect of cathepsin E on female infertility.<\/jats:p>","DOI":"10.5468\/ogs.24254","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T07:50:31Z","timestamp":1743666631000},"page":"237-243","update-policy":"https:\/\/doi.org\/10.5468\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis"],"prefix":"10.5468","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0369-8200","authenticated-orcid":true,"given":"Lidan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mujun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3425","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14020135"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/grh.0000000000000090"},{"key":"ref3","first-page":"deac107","volume-title":"P-491 preliminary analysis of 943 patients using the fertility risk detection tool","author":"De Oliveira Trigo","year":"2022"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.22316"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.22170"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05274-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.148"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-023-01040-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115613"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.04.043"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.02.009"},{"key":"ref12","first-page":"508","volume-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","author":"Kurki","year":"2023"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006706"},{"key":"ref14","first-page":"73","volume-title":"Genomic atlas of the human plasma proteome","author":"Sun","year":"2018"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq151"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1177\/0962280210394459"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169089"},{"key":"ref18","first-page":"888460","volume-title":"The lifestyle modifications and endometrial proteome changes of women with polycystic opvary syndrome and obesity","author":"Abdulkhalikova","year":"2022"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.20168"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-024-01739-w"},{"key":"ref21","first-page":"518","volume-title":"The role of pentraxin 3 and cathepsin B levels in pregnancies complicated by preeclampsia","author":"Tanr\u0131verdi K\u0131l\u0131\u00e7","year":"2024"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05924-3"}],"container-title":["Obstetrics &amp; Gynecology Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ogscience.org\/upload\/pdf\/ogs-24254.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ogscience.org\/journal\/view.php?doi=10.5468\/ogs.24254","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ogscience.org\/upload\/pdf\/ogs-24254.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T07:52:38Z","timestamp":1747900358000},"score":1,"resource":{"primary":{"URL":"http:\/\/ogscience.org\/journal\/view.php?doi=10.5468\/ogs.24254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"URL":"https:\/\/doi.org\/10.5468\/ogs.24254","relation":{},"ISSN":["2287-8580"],"issn-type":[{"type":"electronic","value":"2287-8580"}],"subject":[],"published":{"date-parts":[[2025,5,15]]},"assertion":[{"value":"2024-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-03","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}