{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:18:23Z","timestamp":1790115503432,"version":"4.0.1"},"reference-count":20,"publisher":"Korean Society of Obstetrics and Gynecology","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002636","name":"Inje University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ogscience.org"],"crossmark-restriction":true},"short-container-title":["Obstet Gynecol Sci"],"published-print":{"date-parts":[[2026,3,15]]},"abstract":"<jats:p>Objective To determine whether hysterectomy for benign diseases is associated with the risk of dementia in middle-aged women.Methods We conducted a retrospective cohort study using data from the Korean National Health Insurance Service database (2002-2020). Women aged 40-59 years who underwent hysterectomy for benign indications (n=16,818) were propensity score-matched (1:1) to controls who had not received hysterectomy. Subjects were followed up until the diagnosis of dementia, death, or the end of the study period (2020). Dementia (all types), Alzheimer\u2019s disease (AD), and vascular dementia (VaD) were identified by International Classification of Diseases, 10th revision codes. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for dementia associated with hysterectomy.Results Median follow-up was 11.4 years. Dementia occurred in 302 (1.8%) women who did not undergo hysterectomy and 257 (1.5%) women who underwent hysterectomy (P=0.061). Cox analysis revealed that hysterectomy was not significantly associated with all-cause dementia (HR, 0.865; 95% CI, 0.724-1.033), with a non-significant trend towards reduced risk. Subgroup analysis also failed to identify any significant association; AD (HR, 0.696; 95% CI, 0.463-1.048) and VaD (HR, 0.625; 95% CI, 0.284-1.377) were not significantly associated with an increased hazard.Conclusion In this large Korean cohort, hysterectomy for benign diseases in women aged 40-59 years was not associated with a significant change in the subsequent risk of dementia. Collectively, our results indicate that hysterectomy was not associated with an increased incidence of dementia, including in analyses stratified by adnexal surgery.<\/jats:p>","DOI":"10.5468\/ogs.25364","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T23:22:45Z","timestamp":1771975365000},"page":"144-154","update-policy":"https:\/\/doi.org\/10.5468\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between hysterectomy and dementia risk in Korean women aged 40-59: a nationwide retrospective cohort study"],"prefix":"10.5468","volume":"69","author":[{"given":"Sang-Hee","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5478-634X","authenticated-orcid":true,"given":"Jin-Sung","family":"Yuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3425","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3233\/jad-190654"},{"key":"ref2","volume-title":"","year":"c2025"},{"key":"ref3","first-page":"e105","volume-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019","year":"2022"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)32205-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000007326"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-020-00263-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000314681"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.07.003"},{"key":"ref9","first-page":"1","volume-title":"Hysterectomy uniquely impacts spatial memory in a rat model: a role for the nonpregnant uterus in cognitive processes","author":"Koebele","year":"2019"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2023.105411"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000334764"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3233\/jad-140336"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afae254"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmjph-2024-002120"},{"key":"ref15","volume-title":"","year":"c2021"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.24071"},{"key":"ref17","volume-title":"","year":"c2000"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq433"},{"key":"ref19","first-page":"695","volume-title":"Critical window hypothesis of hormone therapy and cognition: a scientific update on clinical studies","author":"Maki","year":"2013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.17.2170"}],"container-title":["Obstetrics &amp; Gynecology Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ogscience.org\/upload\/pdf\/ogs-25364.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ogscience.org\/journal\/view.php?doi=10.5468\/ogs.25364","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ogscience.org\/upload\/pdf\/ogs-25364.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T04:24:07Z","timestamp":1774239847000},"score":1,"resource":{"primary":{"URL":"http:\/\/ogscience.org\/journal\/view.php?doi=10.5468\/ogs.25364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,15]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"URL":"https:\/\/doi.org\/10.5468\/ogs.25364","relation":{},"ISSN":["2287-8580"],"issn-type":[{"value":"2287-8580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,15]]},"assertion":[{"value":"2025-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}