{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:06:06Z","timestamp":1789977966940,"version":"4.0.1"},"reference-count":26,"publisher":"Korean Society of Obstetrics and Gynecology","issue":"5","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ogscience.org"],"crossmark-restriction":true},"short-container-title":["Obstet Gynecol Sci"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:p>Objective This study evaluated the relationship between serum androgen concentrations and validated insulin sensitivity indices in Korean women with polycystic ovary syndrome (PCOS) and established optimal androgen thresholds for identifying abnormal insulin sensitivity.Methods A total of 180 Korean females aged 18-35 years with newly diagnosed PCOS were enrolled. Fasting-state insulin sensitivity assessment indices (ISAIs) were calculated and participants with abnormal levels according to at least one established ISAI criterion were classified as having abnormal insulin sensitivity. Spearman\u2019s correlation analysis assessed relationships between insulin sensitivity parameters and four androgens: total testosterone (TT), free testosterone (FT), dehydroepiandrosterone sulfate (DHEA-S), and 17\u03b1-hydroxyprogesterone (17-OHP). Receiver operating characteristic (ROC) curve analysis was used to define the most accurate androgen cutoff values for predicting abnormal insulin sensitivity.Results Among the four androgens tested, TT, FT, and DHEA-S showed significant associations with most insulin resistance (IR) parameters, whereas 17-OHP showed no significant correlation. In the ROC curve analysis, only FT achieved moderately accurate predictive performance (area under the curve [AUC], 0.759), while TT, DHEA-S, and 17-OHP showed AUC values indicating less accurate predictions. The optimal FT cutoff to detect abnormal insulin sensitivity was 1.325 pg\/mL (sensitivity, 77.8%; specificity, 64.0%).Conclusion FT showed the strongest association with parameters related to insulin sensitivity and could serve as a complementary opportunistic indicator of IR in PCOS. Women with PCOS who had serum FT levels \u22651.325 pg\/mL were identified as having abnormal insulin sensitivity.<\/jats:p>","DOI":"10.5468\/ogs.26004","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:05:11Z","timestamp":1784192711000},"page":"328-336","update-policy":"https:\/\/doi.org\/10.5468\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimal androgen concentration cut-off values for identifying abnormal insulin sensitivity in Korean women with polycystic ovary syndrome"],"prefix":"10.5468","volume":"69","author":[{"given":"Seula","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonjun","family":"An","sequence":"additional","affiliation":[{"name":"Inje University College of Medicine, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soojin","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9948-0360","authenticated-orcid":true,"given":"Sungwook","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea"},{"name":"Inje University College of Medicine, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3425","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9240569","type":"journal-article"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13061774","type":"journal-article"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfre.2022.12.003","type":"journal-article"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13795","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.6.774","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199608293350902","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/er.20.4.535","type":"journal-article"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1034","type":"journal-article"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.872","type":"journal-article"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.264.2.e197","type":"journal-article"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2586","type":"journal-article"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108263","type":"journal-article"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2523","type":"journal-article"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.31083\/j.ceog5011238","type":"journal-article"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den239","type":"journal-article"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.23103","type":"journal-article"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s12522-015-0204-x","type":"journal-article"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del142","type":"journal-article"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1126\/science.3287615","type":"journal-article"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/39.4.561","type":"journal-article"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad463","type":"journal-article"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00535-0","type":"journal-article"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6869705","type":"journal-article"},{"key":"ref24","first-page":"1655","type":"journal-article","volume-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome\u2020","author":"Teede","year":"2023"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1979.237.3.e214","type":"journal-article"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14132","type":"journal-article"}],"container-title":["Obstetrics &amp; Gynecology Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ogscience.org\/upload\/pdf\/ogs-26004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ogscience.org\/journal\/view.php?doi=10.5468\/ogs.26004","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ogscience.org\/upload\/pdf\/ogs-26004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:37:59Z","timestamp":1789976279000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ogscience.org\/journal\/view.php?doi=10.5468\/ogs.26004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"URL":"https:\/\/doi.org\/10.5468\/ogs.26004","relation":{},"ISSN":["2287-8580"],"issn-type":[{"value":"2287-8580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}