{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T11:13:38Z","timestamp":1781954018915,"version":"3.54.5"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Angeborene St\u00f6rungen der Thrombozytenfunktion sind eine heterogene Gruppe von Erkrankungen, die oft erst bei Auftreten von Blutungen erkannt werden. Im klinischen Bereich haben sich nur wenige Methoden zur Diagnose und Klassifizierung von angeborenen Thrombozytenfunktionsst\u00f6rungen bew\u00e4hrt. F\u00fcr eine rationelle Diagnostik ist ein stufenweises Vorgehen empfehlenswert. Anamnese und klinische Untersuchung sind Grundvoraussetzungen. Das von-Willebrand-Syndrom und andere plasmatische Gerinnungsst\u00f6rungen sollten vor einer spezifischen Thrombozytenfunktionsdiagnostik immer ausgeschlossen werden. Die Bestimmung von Zahl, Gr\u00f6\u00dfe, Volumen (MPV) und Morphologie der Thrombozyten erlauben R\u00fcckschl\u00fcsse auf die zu Grunde liegende St\u00f6rung.<\/jats:p><jats:p>Die PFA-100\u00ae-Verschlusszeit eignet sich als Screening zum Ausschluss schwerer Thrombozytenfunktionsst\u00f6rungen. Die Aggrego metrie erm\u00f6glicht die Untersuchung zahlreicher Aspekte der Thrombozytenfunktion. Die Durchflusszytometrie ist zur Diagnose von Thrombasthenie Glanzmann, Bernard-Soulier- Syndrom und Freisetzungsst\u00f6rungen geeignet. Molekulargenetische Untersuchungen k\u00f6nnen die Verdachtsdiagnose best\u00e4tigen oder zum Nachweis nicht beschriebener Defekte verwendet werden. Hier wird die ungek\u00fcrzte Version der inter -disziplin\u00e4ren Leitlinie* pr\u00e4sentiert.<\/jats:p>","DOI":"10.5482\/hamo-13-04-0024","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T09:42:30Z","timestamp":1402047750000},"page":"201-212","source":"Crossref","is-referenced-by-count":14,"title":["Diagnose angeborener St\u00f6rungen der Thrombozytenfunktion"],"prefix":"10.5482","volume":"34","author":[{"given":"R.","family":"Kn\u00f6fler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Eberl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Schulze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Bakchoul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bergmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gehrisch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Geisen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gottstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Halimeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Harbrecht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kappert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kirchmaier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kehrel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"L\u00f6sche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Krause","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mahnel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Meyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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