{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T18:52:09Z","timestamp":1720723929795},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Immune tolerance induction (ITI) in patients with haemophilia B and inhibitors may be complicated by anaphylactic reactions and nephrotic syndrome with lower success rates than in haemophilia A (25% vs. 50\u201390%). According to case reports, immunosuppressive therapy in addition to high doses of factor IX (FIX) appears to be promising. We report an 18-year-old patient with severe haemophilia B and a FIX inhibitor with a maximum titre of 2.6 Bethesda units and allergic skin reactions to FIX infusions. At 5 years of age, this patient already had a FIX inhibitor with allergic reactions to FIX and activated prothrombin complex concentrate. ITI at 11 years of age with high-dose FIX, de-xamethasone, rituximab, mycophenolate mofetil and intravenous immunoglobulins had induced a sustained response until the current presentation.<\/jats:p><jats:p>The patient was restarted on the same ITI regimen with aforementioned immunosup-pressants, which were initiated one week before high-dose FIX. No allergic reactions, nephrotic syndrome or serious infection occurred during ITI. The FIX inhibitor was unde-tectable after five weeks of treatment and remained so until 19 months of follow-up.<\/jats:p>","DOI":"10.5482\/hamo-14-01-0010","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T07:21:20Z","timestamp":1415604080000},"page":"S5-S8","source":"Crossref","is-referenced-by-count":3,"special_numbering":"S","title":["Successful second ITI with factor IX and combined immunosuppressive therapy"],"prefix":"10.5482","volume":"34","author":[{"given":"R.","family":"Schneppenheim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Schrum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bokemeyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Langer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Holstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,27]]},"reference":[{"key":"10.5482\/HAMO-14-01-0010-1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31815cf742"},{"key":"10.5482\/HAMO-14-01-0010-2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01446.x"},{"key":"10.5482\/HAMO-14-01-0010-3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1356574"},{"key":"10.5482\/HAMO-14-01-0010-4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1055\/s-0037-1617018","volume":"29","author":"Beutel","year":"2009","journal-title":"H\u00e4mostaseologie"},{"key":"10.5482\/HAMO-14-01-0010-5","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12158"},{"key":"10.5482\/HAMO-14-01-0010-6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02039.x"},{"key":"10.5482\/HAMO-14-01-0010-7","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3282f2b5fd"},{"key":"10.5482\/HAMO-14-01-0010-8","doi-asserted-by":"crossref","unstructured":"Collins PW, Chalmers E, Hart DP ET AL. Diagnosis and treatment of factor VIII and IX inhibitors in congenital haemophilia: (4th ed). UK Haemophilia Centres Doctors Organisation. 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Immune tolerance induction with mycophenolate-mofetil in two children with haemophilia B and inhibitor. Haemophilia 2008; 14: 44-49:","DOI":"10.1111\/j.1365-2516.2007.01584.x"},{"key":"10.5482\/HAMO-14-01-0010-16","doi-asserted-by":"crossref","unstructured":"Oldenburg J, Pavlova A. Genetic risk factors for inhibitors to factor VIII and IX. Haemophilia 2006; 12 (Suppl 6): 15-22:","DOI":"10.1111\/j.1365-2516.2006.01361.x"},{"key":"10.5482\/HAMO-14-01-0010-17","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2397-0"},{"key":"10.5482\/HAMO-14-01-0010-18","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199701000-00003"}],"container-title":["H\u00e4mostaseologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.5482\/HAMO-14-01-0010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T16:23:37Z","timestamp":1598459017000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.5482\/HAMO-14-01-0010"}},"subtitle":["A patient with severe haemophilia B and recurrence of a factor IX inhibitor"],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":18,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2017,12,30]]},"published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.5482\/hamo-14-01-0010","relation":{},"ISSN":["0720-9355","2567-5761"],"issn-type":[{"value":"0720-9355","type":"print"},{"value":"2567-5761","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}