{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:48:25Z","timestamp":1788871705236,"version":"build-2803163510"},"reference-count":59,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["2010B029, I.B. 2012T083"],"award-info":[{"award-number":["2010B029, I.B. 2012T083"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Netherlands Cardio Vascular Research Initiative"},{"DOI":"10.13039\/501100012524","name":"Dutch Federation of University Medical Centres","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012524","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Rupture of an atherosclerotic plaque is the major underlying cause of adverse cardiovascular events such as myocardial infarction or stroke. Therapeutic interventions should therefore be directed towards inhibiting growth of atherosclerotic lesions as well as towards prevention of lesion destabilization. Interestingly, the presence of mast cells has been demonstrated in both murine and human plaques, and multiple interventional murine studies have pointed out a direct role for mast cells in early and late stages of atherosclerosis. Moreover, it has recently been described that activated lesional mast cells correlate with major cardiovascular events in patients suffering from cardiovascular disease.<\/jats:p>\n                  <jats:p>This review focuses on the effect of different mast cell derived mediators in atherogenesis and in late stage plaque destabilization. Also, possible ligands for mast cell activation in the context of atherosclerosis are discussed. Finally, we will elaborate on the predictive value of mast cells, together with therapeutic implications, in cardiovascular disease.<\/jats:p>","DOI":"10.5482\/hamo-14-08-0034","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T07:55:29Z","timestamp":1415346929000},"page":"113-120","source":"Crossref","is-referenced-by-count":11,"title":["The role of mast cells in atherosclerosis"],"prefix":"10.5482","volume":"35","author":[{"given":"A.","family":"Wezel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. H. A.","family":"Quax","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kuiper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,12,28]]},"reference":[{"key":"10.5482\/HAMO-14-08-0034-1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1460"},{"key":"10.5482\/HAMO-14-08-0034-2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62055-X"},{"key":"10.5482\/HAMO-14-08-0034-3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1182\/blood.V52.2.447.447","volume":"52","author":"Kitamura","year":"1978","journal-title":"Blood"},{"key":"10.5482\/HAMO-14-08-0034-4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00052.x"},{"key":"10.5482\/HAMO-14-08-0034-5","doi-asserted-by":"publisher","DOI":"10.1126\/science.117.3045.505"},{"key":"10.5482\/HAMO-14-08-0034-6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302721"},{"key":"10.5482\/HAMO-14-08-0034-7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht186"},{"key":"10.5482\/HAMO-14-08-0034-8","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199610000-00004"},{"key":"10.5482\/HAMO-14-08-0034-9","unstructured":"Kovanen PT. The\u00a0mast\u00a0cell--a\u00a0potential\u00a0link\u00a0between\u00a0inflammation\u00a0and cellular cholesterol deposition in atherogenesis. Eur Heart J\u00a01993; 14 Suppl K: 105-117"},{"key":"10.5482\/HAMO-14-08-0034-10","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000041405.07367.B5"},{"key":"10.5482\/HAMO-14-08-0034-11","doi-asserted-by":"publisher","DOI":"10.1038\/29788"},{"key":"10.5482\/HAMO-14-08-0034-12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.745091"},{"key":"10.5482\/HAMO-14-08-0034-13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-486217"},{"key":"10.5482\/HAMO-14-08-0034-14","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300857"},{"key":"10.5482\/HAMO-14-08-0034-15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303479"},{"key":"10.5482\/HAMO-14-08-0034-16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.961714"},{"key":"10.5482\/HAMO-14-08-0034-17","doi-asserted-by":"crossref","unstructured":"Bot I, Wezel A, Lagraauw HM et al. Mast cell mediated neutrophil influx enhances plaque progression. Cardiovasc Res 2014; 103 Suppl 1: S5","DOI":"10.1093\/cvr\/cvu078.1"},{"key":"10.5482\/HAMO-14-08-0034-18","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00336-X"},{"key":"10.5482\/HAMO-14-08-0034-19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.660472"},{"key":"10.5482\/HAMO-14-08-0034-20","doi-asserted-by":"publisher","DOI":"10.1038\/nm1601"},{"key":"10.5482\/HAMO-14-08-0034-21","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/jcb.22443","volume":"109","author":"Heikkil\u00e4","year":"2010","journal-title":"J Cell Biochem"},{"key":"10.5482\/HAMO-14-08-0034-22","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.5.1262"},{"key":"10.5482\/HAMO-14-08-0034-23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.5.1084"},{"key":"10.5482\/HAMO-14-08-0034-24","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.6.966"},{"key":"10.5482\/HAMO-14-08-0034-25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2011.06.004"},{"key":"10.5482\/HAMO-14-08-0034-26","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(00)00076-5"},{"key":"10.5482\/HAMO-14-08-0034-27","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.11.1707"},{"key":"10.5482\/HAMO-14-08-0034-28","first-page":"1289","volume":"312","author":"Leskinen","year":"2006","journal-title":"Exp\u00a0Cell\u00a0Res"},{"key":"10.5482\/HAMO-14-08-0034-29","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.151340"},{"key":"10.5482\/HAMO-14-08-0034-30","first-page":"133","volume":"48","author":"Tani\u00a0K,","year":"2001","journal-title":"J Med Invest"},{"key":"10.5482\/HAMO-14-08-0034-31","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq260"},{"key":"10.5482\/HAMO-14-08-0034-32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060960"},{"key":"10.5482\/HAMO-14-08-0034-33","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000140820.51174.8d"},{"key":"10.5482\/HAMO-14-08-0034-34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008816107"},{"key":"10.5482\/HAMO-14-08-0034-35","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.201079"},{"key":"10.5482\/HAMO-14-08-0034-36","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46028"},{"key":"10.5482\/HAMO-14-08-0034-37","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-156083"},{"key":"10.5482\/HAMO-14-08-0034-38","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs312"},{"key":"10.5482\/HAMO-14-08-0034-39","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12357"},{"key":"10.5482\/HAMO-14-08-0034-40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00185"},{"key":"10.5482\/HAMO-14-08-0034-41","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000109140.51366.72"},{"key":"10.5482\/HAMO-14-08-0034-42","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.250605"},{"key":"10.5482\/HAMO-14-08-0034-43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088984"},{"key":"10.5482\/HAMO-14-08-0034-44","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.11.024"},{"key":"10.5482\/HAMO-14-08-0034-45","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M032862"},{"key":"10.5482\/HAMO-14-08-0034-46","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.14.1665"},{"key":"10.5482\/HAMO-14-08-0034-47","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.204875"},{"key":"10.5482\/HAMO-14-08-0034-48","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.04.025"},{"key":"10.5482\/HAMO-14-08-0034-49","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2013.02.022"},{"key":"10.5482\/HAMO-14-08-0034-50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04198.x"},{"key":"10.5482\/HAMO-14-08-0034-51","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.21.2521"},{"key":"10.5482\/HAMO-14-08-0034-52","doi-asserted-by":"crossref","unstructured":"Skaaby\u00a0T, Husemoen LL, Thuesen BH et al. The association of atopy with incidence of ischemic heart disease, stroke, and diabetes. Endocrine 2014; Epub ahead of print","DOI":"10.1007\/s12020-014-0321-z"},{"key":"10.5482\/HAMO-14-08-0034-53","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.09.008"},{"key":"10.5482\/HAMO-14-08-0034-54","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(00)00475-7"},{"key":"10.5482\/HAMO-14-08-0034-55","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.13.1434"},{"key":"10.5482\/HAMO-14-08-0034-56","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.10.002"},{"key":"10.5482\/HAMO-14-08-0034-57","doi-asserted-by":"crossref","unstructured":"Matsumura T, Taketa K, Motoshima H et al. Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes. Cardiovasc Diabetol 2013; 27; 12: 177.\u00a0","DOI":"10.1186\/1475-2840-12-177"},{"key":"10.5482\/HAMO-14-08-0034-58","doi-asserted-by":"publisher","DOI":"10.1139\/Y08-107"},{"key":"10.5482\/HAMO-14-08-0034-59","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000028335.31300.DA"}],"container-title":["H\u00e4mostaseologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.5482\/HAMO-14-08-0034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T17:12:19Z","timestamp":1717521139000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.5482\/HAMO-14-08-0034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":59,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2017,12,28]]},"published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.5482\/hamo-14-08-0034","relation":{},"ISSN":["0720-9355","2567-5761"],"issn-type":[{"value":"0720-9355","type":"print"},{"value":"2567-5761","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}