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The pathophysiology of Trousseau\u2019s syndrome involves all aspects of Virchow\u2019s triad, but previous basic research has mainly focused on the cellular and molecular mechanisms underlying blood hypercoagulability in solid cancers and haematological malignancies. In this regard, over-expression of tissue factor (TF), the principal initiator of the extrinsic coagulation pathway, by primary tumour cells and increased shedding of TF-bearing plasma microparticles are critical to both thrombus formation and cancer progression. However, novel findings on intrinsic contact activation in vivo, such as the release of polyphosphates or DNA by activated platelets and neutrophils, respectively, have pointed to additional pathways in the complex pathophysiology of Trousseau\u2019s syndrome.<\/jats:p>","DOI":"10.5482\/hamo-14-08-0037","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T11:56:40Z","timestamp":1416311800000},"page":"52-59","source":"Crossref","is-referenced-by-count":25,"title":["Pathophysiology of Trousseau\u2019s 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