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Vergleicht man Patienten mit einer chronischen Niereninsuffizienz mit Patienten, die zus\u00e4tzlich folgende Risikofaktoren aufweisen, erh\u00f6ht sich das TE-Risiko erheblich: CKD und arterielle Thrombose: OR 4.9, CKD und maligne Grunderkrankung: OR 5.8, CKD und chirurgischer Eingriff: OR14.0; CKD und angeborene Thrombophilie (OR 4.3).<\/jats:p><jats:p>Die Behandlung der terminalen Niereninsuffizienz besteht in Dialyse, Peritonaldialyse und Nierentransplantation. Bei allen Verfahren sind thromboembolische Komplikationen beschrieben. TEs, insbesondere aber Katheter-assoziierte Thrombosen oder Shuntverschl\u00fcsse treten in bis zu 25% der Dialysepatienten auf. Die Inzidenz einer Nierenvenenthrombose als Komplikation nach Nierentransplantation \u2013 verbunden mit hoher Wahrscheinlichkeit eines Organverlustes \u2013 wird mit 2\u201312% angegeben.<\/jats:p><jats:p>Da TE h\u00e4ufig multifaktoriell bedingt sind, erscheint ein generelles Screening auf Thrombophilie in diesem Patientenklientel nicht indiziert. Ein Screening sollte diskutiert werden bei Patienten, die entweder TEs vor Auftreten ihrer Nierenerkrankung entwickelt haben oder die eine positive Familienanamnese hinsichtlich VTE aufweisen. Auch Patienten, die unter Dialyse oder nach Transplantation multiple TEs erleiden und solche, die auf der Warteliste f\u00fcr eine Nierentransplantation (insbesondere Lebendspende) stehen, sollten hinsichtlich Thrombophilie untersucht werden.<\/jats:p>","DOI":"10.5482\/hamo-14-11-0063","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T09:09:28Z","timestamp":1422868168000},"page":"103-107","source":"Crossref","is-referenced-by-count":23,"title":["End-stage renal disease and thrombophilia"],"prefix":"10.5482","volume":"36","author":[{"given":"Alexander","family":"Bauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Limperger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Nowak-G\u00f6ttl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"key":"10.5482\/HAMO-14-11-0063-1","doi-asserted-by":"crossref","unstructured":"Kim WY, Huh JW, Lim CM ET AL: Analysis of progression in risk, injury, fail, loss and end-stage renal disease classification on outcome in patients with severe sepsis and septic shock. 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