{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:43:21Z","timestamp":1773747801577,"version":"3.50.1"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Non-arteritic anterior ischaemic optic neuropathy (NAION) is caused by ischaemia of the optic nerve head. The pathophysiology of NAION is unclear, and no proven effective treatment exists. Patients, methods: We analyzed thrombophilic risk factors and determinants of atherosclerosis and inflammation in 109 consecutive patients and 109 age- and sex-matched volunteers using a case-control design. Results: High levels of fibrinogen (&gt;384 mg\/dl; OR 3.2, p = 0.003), factors VIII:C (&gt;183%; OR 2.6, p = 0.02), IX (&gt;153%; OR 2.6, p = 0.026), XI (&gt;142%; OR 3.4, p = 0.006), von Willebrand factor (activity &gt;205%; OR 3.1, p = 0.005; antigen &gt;194%; OR 3.5, p = 0.002), and triglycerides (&gt;228 mg\/dl; OR 2.8, p = 0.026), higher platelet counts (&gt;294 000\/[uni03BC]l; OR 2.5, p = 0.04), low levels of HDL cholesterol (&lt;40 mg\/dl; OR 2.7, p = 0.032), and an accelerated erythrocyte sedimentation rate (&gt;20 mm\/h; OR 4.4, p = 0.003) were associated with NAION. Conclusion: Our findings support the contention of a complex pathogenesis of NAION resulting from the coincidence of proatherogenic, prothrombotic and proinflammatory processes. The alterations described could be causative, side effects, or just coincidental findings.<\/jats:p>","DOI":"10.5482\/hamo-15-10-0028","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T08:23:35Z","timestamp":1453105415000},"page":"46-54","source":"Crossref","is-referenced-by-count":10,"title":["Associations between thrombophilic risk factors and determinants of atherosclerosis and inflammation in patients with non-arteritic anterior ischaemic optic neuropathy"],"prefix":"10.5482","volume":"36","author":[{"given":"C.","family":"Finger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. B.","family":"Zotz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Scharf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Uns\u00f6ld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"10.5482\/HAMO-15-10-0028-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2009.06.008"},{"key":"10.5482\/HAMO-15-10-0028-2","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200306000-00012"},{"key":"10.5482\/HAMO-15-10-0028-3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.3.386"},{"key":"10.5482\/HAMO-15-10-0028-4","first-page":"203","volume":"98","author":"Knox","year":"2000","journal-title":"Trans Am Ophthalmol Soc"},{"key":"10.5482\/HAMO-15-10-0028-5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1413352"},{"key":"10.5482\/HAMO-15-10-0028-6","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-199403000-00011"},{"key":"10.5482\/HAMO-15-10-0028-7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70999-7"},{"key":"10.5482\/HAMO-15-10-0028-8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2008.00287.x"},{"key":"10.5482\/HAMO-15-10-0028-9","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(79)90414-8"},{"key":"10.5482\/HAMO-15-10-0028-10","doi-asserted-by":"publisher","DOI":"10.3109\/08820539509060976"},{"key":"10.5482\/HAMO-15-10-0028-11","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140566007"},{"key":"10.5482\/HAMO-15-10-0028-12","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00079-4"},{"key":"10.5482\/HAMO-15-10-0028-13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.03.032"},{"key":"10.5482\/HAMO-15-10-0028-14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.07.062"},{"key":"10.5482\/HAMO-15-10-0028-15","doi-asserted-by":"crossref","unstructured":"Biousse V, Kerrison JB, Newman NJ. Is non-arteritic anterior ischaemic optic neuropathy related to homocysteine? Br J Ophthalmol 2000; 84: 555-","DOI":"10.1136\/bjo.84.5.554c"},{"key":"10.5482\/HAMO-15-10-0028-16","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2003.10.015"},{"key":"10.5482\/HAMO-15-10-0028-17","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-1154-5"},{"key":"10.5482\/HAMO-15-10-0028-18","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00181-0"},{"key":"10.5482\/HAMO-15-10-0028-19","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00873-4"},{"key":"10.5482\/HAMO-15-10-0028-20","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.179"},{"key":"10.5482\/HAMO-15-10-0028-21","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0987-0"},{"key":"10.5482\/HAMO-15-10-0028-22","doi-asserted-by":"publisher","DOI":"10.3109\/01658100903582811"},{"key":"10.5482\/HAMO-15-10-0028-23","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1027488"},{"key":"10.5482\/HAMO-15-10-0028-24","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0981-6"},{"key":"10.5482\/HAMO-15-10-0028-25","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1115"},{"key":"10.5482\/HAMO-15-10-0028-26","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0979-0"},{"key":"10.5482\/HAMO-15-10-0028-27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1055\/s-0037-1613602","volume":"90","author":"Gerhardt","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.5482\/HAMO-15-10-0028-28","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000144282.42222.DA"},{"key":"10.5482\/HAMO-15-10-0028-29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91026-7"},{"key":"10.5482\/HAMO-15-10-0028-30","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00031-9"},{"key":"10.5482\/HAMO-15-10-0028-31","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90550-I"},{"key":"10.5482\/HAMO-15-10-0028-32","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90159-8"},{"key":"10.5482\/HAMO-15-10-0028-33","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1995.13"},{"key":"10.5482\/HAMO-15-10-0028-34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01199.x"},{"key":"10.5482\/HAMO-15-10-0028-35","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200404000-00006"},{"key":"10.5482\/HAMO-15-10-0028-36","doi-asserted-by":"crossref","unstructured":"Ginsburg D. Genetic risk factors for arterial thrombosis and inflammation. Hematology Am Soc Hematol Educ Program 2005; 442-444","DOI":"10.1182\/asheducation-2005.1.442"},{"key":"10.5482\/HAMO-15-10-0028-37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00743.x"},{"key":"10.5482\/HAMO-15-10-0028-38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1055\/s-0037-1617169","volume":"28","author":"Zotz","year":"2008","journal-title":"Hamostaseologie"},{"key":"10.5482\/HAMO-15-10-0028-39","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2004.09.009"},{"key":"10.5482\/HAMO-15-10-0028-40","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1182\/blood.V95.12.3678","volume":"95","author":"Vlieg","year":"2000","journal-title":"Blood"},{"key":"10.5482\/HAMO-15-10-0028-41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003093421004"},{"key":"10.5482\/HAMO-15-10-0028-42","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92237-3"},{"key":"10.5482\/HAMO-15-10-0028-43","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-55-1-33"},{"key":"10.5482\/HAMO-15-10-0028-44","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008748"},{"key":"10.5482\/HAMO-15-10-0028-45","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60447-5"},{"key":"10.5482\/HAMO-15-10-0028-46","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-008-1814-z"}],"container-title":["H\u00e4mostaseologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.5482\/HAMO-15-10-0028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T02:51:23Z","timestamp":1600051883000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.5482\/HAMO-15-10-0028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":46,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2017,12,29]]},"published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.5482\/hamo-15-10-0028","relation":{},"ISSN":["0720-9355","2567-5761"],"issn-type":[{"value":"0720-9355","type":"print"},{"value":"2567-5761","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}