{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:19:27Z","timestamp":1784841567150,"version":"3.55.0"},"reference-count":83,"publisher":"Korean Society for Biochemistry and Molecular Biology - BMB Reports","issue":"11","funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015R1A5A1009701"],"award-info":[{"award-number":["2015R1A5A1009701"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.bmbreports.org"],"crossmark-restriction":true},"short-container-title":["BMB Rep."],"published-print":{"date-parts":[[2019,11,30]]},"DOI":"10.5483\/bmbrep.2019.52.11.267","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T11:07:12Z","timestamp":1575284832000},"page":"625-634","update-policy":"https:\/\/doi.org\/10.5483\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Severe combined immunodeficiency pig as an emerging animal model for human diseases and regenerative medicines"],"prefix":"10.5483","volume":"52","author":[{"given":"Muhammad Arsalan","family":"Iqbal","sequence":"first","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Humanized Pig Research Center (SRC), Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwonho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Humanized Pig Research Center (SRC), Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hoi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Humanized Pig Research Center (SRC), Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Humanized Pig Research Center (SRC), Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3442","reference":[{"key":"ref1","unstructured":"Tasher D, and Dalal I (2012) The genetic basis of severe combined immunodeficiency and its variants. Appl Clin Genet 5, 67-80"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.29245\/2572-9411\/2017\/3.1103"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104614"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-36-76"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/377065a0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90167-O"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5237.797"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1631559"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266076"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266077"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06576.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.1.1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.05.013"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/35105066"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.179"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nri1435"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00754.x"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Peter HH, Friedrich W, and Dopfer R et al (1983) NK cell function in severe combined immunodeficiency (SCID): evidence of a common T and NK cell defect in some but not all SCID patients. J Immunol 131, 2332-2339","DOI":"10.4049\/jimmunol.131.5.2332"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60450-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)80044-1"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.81"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldv020"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11485"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90030-G"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90029-C"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-219907"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.85"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/2045-9769-3-3"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400915"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-476432"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70199-9"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.053"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.8.1039"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/nri1939"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132706"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.2.1308"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0247"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80205-8"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3205"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/12.4.449"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00704-3"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(03)00104-3"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1038\/ng.265"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1038\/ng.278"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.52.127"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101443"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Yagi H, Matsumoto M, and Nakamura M et al (1996) Defect of thymocyte emigration in a T cell deficiency strain (CTS) of the mouse. J Immunol 157, 3412-3419","DOI":"10.4049\/jimmunol.157.8.3412"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1662"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/ni1570"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.11.023"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.11.002"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.042"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314975111"},{"key":"ref54","unstructured":"McKusick VA, Eldridge R, Hostetler JA, Ruangwit U, and Egeland JA (1965) Dwarfism in the amish. Ii. cartilage-hair hypoplasia. Bull Johns Hopkins Hosp 116, 285-326"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.08.004"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-017-0228-7"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2013.04.004"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1409"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009424107"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172447"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-13-60"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106422108"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.70"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12019"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.21271"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr218"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1002\/9780470151808.sc05b03s34"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1927"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20626"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1126\/science.1225829"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231143"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.11"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.121723"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4187"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.04.021"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.50.2.168"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076478"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-016-0206-5"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1406376111"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-332"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2011.11.002"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.2"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113833"}],"container-title":["BMB Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pdf.medrang.co.kr\/BMB\/2019\/052\/BMB052-11-01.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:11:27Z","timestamp":1695478287000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.bmbreports.org\/journal\/view.html?doi=10.5483\/BMBRep.2019.52.11.267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,30]]},"references-count":83,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11,30]]}},"alternative-id":["10.5483\/BMBRep.2019.52.11.267"],"URL":"https:\/\/doi.org\/10.5483\/bmbrep.2019.52.11.267","relation":{},"ISSN":["1976-670X"],"issn-type":[{"value":"1976-670X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,30]]},"assertion":[{"value":"http:\/\/www.bmbreports.org\/journal\/view.html?doi=10.5483\/BMBRep.2019.52.11.267","URL":"http:\/\/www.bmbreports.org\/journal\/view.html?doi=10.5483\/BMBRep.2019.52.11.267","name":"the_journal","label":"BMB Reports","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2019-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-30","order":1,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2019 The Korean Society for Biochemistry and Molecular Biology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}