{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:38:11Z","timestamp":1771515491484,"version":"3.50.1"},"reference-count":0,"publisher":"Canadian Urological Association Journal","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CUAJ"],"abstract":"<jats:p>Introduction: Phenotypic differentiation of patients with interstitial cystitis\/bladder pain syndrome (IC\/BPS) may improve our understanding of the condition, as well as the development of patient-specific treatment strategies. We identified a distinct subgroup of IC\/BPS patients with a multiple sensitivity phenotype.Methods: We defined patients with this IC\/BPS associated multiple sensitivity syndrome as having at least 3 confirmed allergies\/sensitivities to medications and\/or environmental factors and a diagnosis of IC\/BPS. These IC\/BPS patients identified with a multiple sensitivity phenotype (cases) were compared to age-matched IC\/BPS patients with few or no allergies (controls) at a 1:2 ratio. Comparisons were undertaken using standardized case assessment parameters (age, duration of symptoms, medical history, Interstitial Cystitis Symptoms Index [ICSI] and pelvic pain and urinary urgency\/frequency [PUF] symptom scores, and urinary, psychosocial, organ specific, infection, neurologic\/systemic, tenderness [UPOINT] categorization).Results: The study consisted of 17 cases and 34 age-matched controls; the mean age was 55 and 56 years, respectively. There was statistically more medication and environmental allergies in the cases versus controls. Cases reported more concomitant illnesses (9.6 vs. 6.2, p &lt; 0.001) and number of bodily systems affected (6.0 vs. 3.8, p \u2264 0.001). The prevalence of irritable bowel syndrome and fibromyalgia was higher in the case group (p = 0.028, p \u2264 0.001, respectively). Additionally, there were more reported psychiatric diseases (p = 0.019), allergic\/immune diseases (p = 0.003), and pulmonary diseases (p &lt; 0.001) in the case group. UPOINT classification differed with more patients in the case group being categorized in the psychosocial and neuropathic\/systemic domains (p = 0.045, p = 0.007, respectively). Total UPOINT classification (out of 6) was also higher in cases than controls (4.6 vs. 3.2, p = 0.001, respectively).Conclusions: We have characterized a distinct phenotypic group of patients with IC\/BPS and multiple sensitivities. The limitations of our study include the retrospective case-control matching design, biases in phenotype definition, single centre patient recruitment, and the lack of follow-up. Nonetheless, the observation of this specific phenotype suggests that further research in this group may help develop targeted therapeutic strategies for patients with a concomitant multiple sensitivity syndrome and IC\/BPS.<\/jats:p>","DOI":"10.5489\/cuaj.2031","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T01:28:34Z","timestamp":1416878914000},"page":"758","source":"Crossref","is-referenced-by-count":20,"title":["Multiple sensitivity phenotype in interstitial cystitis\/bladder pain syndrome"],"prefix":"10.5489","volume":"8","author":[{"given":"Michael","family":"Fuoco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Irvine-Bird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Curtis","family":"Nickel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3456","published-online":{"date-parts":[[2014,11,24]]},"container-title":["Canadian Urological Association Journal"],"original-title":[],"link":[{"URL":"http:\/\/www.cuaj.ca\/index.php\/journal\/article\/viewFile\/2031\/1912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.cuaj.ca\/index.php\/journal\/article\/viewFile\/2031\/1912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T19:47:21Z","timestamp":1501616841000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.cuaj.ca\/index.php\/journal\/article\/view\/2031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,24]]},"references-count":0,"journal-issue":{"issue":"11-12","published-online":{"date-parts":[[2014,11,24]]}},"URL":"https:\/\/doi.org\/10.5489\/cuaj.2031","relation":{},"ISSN":["1920-1214","1911-6470"],"issn-type":[{"value":"1920-1214","type":"electronic"},{"value":"1911-6470","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11,24]]}}}